Results 11 to 20 of about 222,465 (345)

Effect of age and cytoskeletal elements on the indentation-dependent mechanical properties of chondrocytes. [PDF]

, 2013
Articular cartilage chondrocytes are responsible for the synthesis, maintenance, and turnover of the extracellular matrix, metabolic processes that contribute to the mechanical properties of these cells.
Blanchette, Craig, Chahine, Nadeen O, Haudenschild, Dominik, Loots, Gabriela G, Lu, Jeffrey, Thomas, Cynthia B   +5 more
core   +12 more sources

Combination of chondrocytes and chondrons improves extracellular matrix production to promote the repairs of defective knee cartilage in rabbits

Journal of Orthopaedic Translation, 2021
Background: Chondrons are composed of chondrocytes and the surrounding pericellular matrix (PCM) and function to enhance chondrocyte-mediated cartilage tissue engineering.
Wangping Duan, Yu Zhao, Xiaochun Ren, Ruipeng Zhao, Qi Li, Zhenwei Sun, Wenjie Song, Yanfei Yang, Pengcui Li, Xiaochun Wei   +9 more
doaj   +1 more source

Role of Mitochondria in Physiology of Chondrocytes and Diseases of Osteoarthritis and Rheumatoid Arthritis

Cartilage, 2021
Purpose of Review Mitochondria are recognized to be one of the most important organelles in chondrocytes for their role in triphosphate (ATP) generation through aerobic phosphorylation.
Shiyi Kan, Mengmeng Duan, Yang Liu, Chunli Wang, Jing Xie   +4 more
semanticscholar   +1 more source

miR-107 affects cartilage matrix degradation in the pathogenesis of knee osteoarthritis by regulating caspase-1

Journal of Orthopaedic Surgery and Research, 2021
Background Knee osteoarthritis (KOA) seriously affects the quality of life of KOA patients. This study aimed to investigate whether miR-107 could regulate KOA through pyroptosis to affect collagen protein secreted by chondrocytes through IL-1β.
Jiatian Qian, Peiliang Fu, Shiao Li, Xiang Li, Yancheng Chen, Zhenen Lin   +5 more
doaj   +1 more source

Effect of growth hormone releasing hormone on chondrocytes of osteoarthritis [PDF]

The Korean Journal of Internal Medicine, 2022
Background/Aims To evaluate the effect and possible mechanism of growth hormone releasing hormone (GHRH) on chondrocytes of osteoarthritis (OA). Methods Articular chondrocytes were cultured and the expression of GHRH receptor in chondrocytes was detected.
Zhuoran LI, Yao LI
doaj   +1 more source

Single-Cell RNA-Seq Reveals Transcriptomic Heterogeneity and Post-Traumatic Osteoarthritis-Associated Early Molecular Changes in Mouse Articular Chondrocytes

Cells, 2021
Articular cartilage is a connective tissue lining the surfaces of synovial joints. When the cartilage severely wears down, it leads to osteoarthritis (OA), a debilitating disease that affects millions of people globally.
A. Sebastian, Jillian L McCool, N. Hum, D. Murugesh, Stephen P Wilson, B. Christiansen, G. Loots   +6 more
semanticscholar   +1 more source

BMSC-Derived Exosomes Ameliorate Osteoarthritis by Inhibiting Pyroptosis of Cartilage via Delivering miR-326 Targeting HDAC3 and STAT1//NF-κB p65 to Chondrocytes

Mediators of Inflammation, 2021
Background. In the past decade, mesenchymal stem cells (MSCs) have been widely used for the treatment of osteoarthritis (OA), and noncoding RNAs in exosomes may play a major role. Aim.
Honggang Xu, Bin Xu
semanticscholar   +1 more source

Dysregulation of Cells Cycle and Apoptosis in Human Induced Pluripotent Stem Cells Chondrocytes Through p53 Pathway by HT-2 Toxin: An in vitro Study

Frontiers in Genetics, 2021
Kashin–Beck disease (KBD) mainly damages growth plate of adolescents and is susceptible to both gene and gene–environmental risk factors. HT-2 toxin, which is a primary metabolite of T-2 toxin, was regarded as one of the environmental risk factors of KBD.
Yanan Zhang, Yanan Zhang, Huan Liu, Huan Liu, Xialu Lin, Xialu Lin, Feng’e Zhang, Feng’e Zhang, Peilin Meng, Peilin Meng, Sijia Tan, Sijia Tan, Mikko J. Lammi, Mikko J. Lammi, Xiong Guo, Xiong Guo   +15 more
doaj   +1 more source

Flightless I is a catabolic factor of chondrocytes that promotes hypertrophy and cartilage degeneration in osteoarthritis

iScience, 2021
Summary: Synovial macrophages that are activated by cartilage fragments initiate synovitis, a condition that promotes hypertrophic changes in chondrocytes leading to cartilage degeneration in OA.
Taku Ebata, Mohamad Alaa Terkawi, Masanari Hamasaki, Gen Matsumae, Tomohiro Onodera, Mahmoud Khamis Aly, Shunichi Yokota, Hend Alhasan, Tomohiro Shimizu, Daisuke Takahashi, Kentaro Homan, Ken Kadoya, Norimasa Iwasaki   +12 more
doaj   +1 more source

Chondrocytes in the resting zone of the growth plate are maintained in a Wnt-inhibitory environment

eLife, 2021
Chondrocytes in the resting zone of the postnatal growth plate are characterized by slow cell cycle progression, and encompass a population of parathyroid hormone-related protein (PTHrP)-expressing skeletal stem cells that contribute to the formation of ...
Shawn A Hallett, Yuki Matsushita, Wanida Ono, Naoko Sakagami, Koji Mizuhashi, Nicha Tokavanich, Mizuki Nagata, Annabelle Zhou, Takao Hirai, Henry M Kronenberg, Noriaki Ono   +10 more
doaj   +1 more source