Results 11 to 20 of about 99,218 (314)

Ultrasound Protects Human Chondrocytes from Biochemical and Ultrastructural Changes Induced by Oxidative Stress

Applied Sciences, 2022
The aim of the study was to assess the effects of therapeutic ultrasound (US) on oxidative stress (OS)-induced changes in cultured human chondrocytes (HCH). For this, monolayer HCH were randomized in three groups: a control group (CG), a group exposed to
Rodica Ana Ungur, Adriana Muresan, Diana Elena Olteanu, Adrian Florea, Viorela Mihaela Ciortea, Laszlo Irsay, Ileana Monica Borda, Răzvan Andrei Codea, Ciprian Andrei Ober, Ștefana Bâlici, Simona Căinap, Eleonora Dronca, Georgiana Smaranda Martiș (Petruț), Ioana Anamaria Onac, Şoimiţa Mihaela Suciu   +14 more
doaj   +1 more source

Mitochondrial transfer from bone-marrow-derived mesenchymal stromal cells to chondrocytes protects against cartilage degenerative mitochondrial dysfunction in rats chondrocytes

Chinese Medical Journal, 2021
. Background. Previous studies have reported that mitochondrial dysfunction participates in the pathological process of osteoarthritis (OA). However, studies that improve mitochondrial function are rare in OA. Mitochondrial transfer from mesenchymal stem
Rui Wang, Talatibaike Maimaitijuma, Yuan-Yuan Ma, Yang Jiao, Yong-Ping Cao, Qiang Shi   +5 more
doaj   +1 more source

Comparison of Apoptosis and Autophagy in Human Chondrocytes Induced by the T-2 and HT-2 Toxins

Toxins, 2019
In this report, we have investigated the apoptosis and autophagy of chondrocytes induced by the T-2 and HT-2 toxins. The viability of chondrocytes was measured by the MTT assay.
Fang-Fang Yu, Xia-Lu Lin, Xi Wang, Zhi-Guang Ping, Xiong Guo   +4 more
doaj   +1 more source

SPRY4 acts as an indicator of osteoarthritis severity and regulates chondrocyte hypertrophy and ECM protease expression

npj Regenerative Medicine, 2021
Osteoarthritis (OA) causes serious changes in the metabolic and signaling pathways of chondrocytes, including the mitogen-activated protein kinase (MAPK) pathway.
Sunghyun Park, Yoshie Arai, Alvin Bello, Hansoo Park, Dohyun Kim, Kyung-Soon Park, Soo-Hong Lee   +6 more
doaj   +1 more source

Fibroblast Growth Factor 18 Increases the Trophic Effects of Bone Marrow Mesenchymal Stem Cells on Chondrocytes Isolated from Late Stage Osteoarthritic Patients

Stem Cells International, 2014
Coculture of mesenchymal stem cells with chondrocytes increases production of cartilaginous matrix. Chondrocytes isolated from late stage osteoarthritic patients usually lost their phenotype of producing cartilaginous matrix.
Zhenyu Zhang, Yan Wang, Mingchao Li, Jiaping Li, Jian Wu   +4 more
doaj   +1 more source

CCL2 induces articular chondrocyte MMP expression through ERK and p38 signaling pathways

Osteoarthritis and Cartilage Open, 2021
Objective: In previous studies, we determined an association between increased serum and articular cartilage levels of CCL2 with osteoarthritis (OA) progression, cartilage damage and increased MMP13 in cartilage.
Helen Willcockson, Huseyin Ozkan, Susan Chubinskaya, Richard F. Loeser, Lara Longobardi   +4 more
doaj   +1 more source

Human iPSC-derived chondrocytes mimic juvenile chondrocyte function for the dual advantage of increased proliferation and resistance to IL-1β

Stem Cell Research & Therapy, 2017
Background Induced pluripotent stem cells (iPSC) provide an unlimited patient-specific cell source for regenerative medicine. Adult cells have had limited success in cartilage repair, but juvenile chondrocytes (from donors younger than 13 years of age ...
Jieun Lee, Piera Smeriglio, Constance R. Chu, Nidhi Bhutani   +3 more
doaj   +1 more source

Senolytic Peptide FOXO4-DRI Selectively Removes Senescent Cells From in vitro Expanded Human Chondrocytes

Frontiers in Bioengineering and Biotechnology, 2021
Autologous chondrocyte implantation (ACI) is a procedure used to treat articular cartilage injuries and prevent the onset of post-traumatic osteoarthritis.
Yuzhao Huang, Yuzhao Huang, Yuchen He, Meagan J. Makarcyzk, Meagan J. Makarcyzk, Hang Lin, Hang Lin, Hang Lin   +7 more
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Differences in Cartilage-Forming Capacity of Expanded Human Chondrocytes from Ear and Nose and Their Gene Expression Profiles

Cell Transplantation, 2011
The aim of this study was to evaluate the potential of culture-expanded human auricular and nasoseptal chondrocytes as cell source for regeneration of stable cartilage and to analyze the differences in gene expression profile of expanded chondrocytes ...
Catharine A. Hellingman, Eugène T. P. Verwiel, Inez Slagt, Wendy Koevoet, René M. L. Poublon, Gilbert J. Nolst-Trenité, Robert J. Baatenburg De Jong, Holger Jahr, Gerjo J. V. M. Van Osch   +8 more
doaj   +1 more source

Expressions of local renin-angiotensin system components in chondrocytes

European Journal of Histochemistry, 2014
In 2013, we reported that local renin-angiotensin system (local RAS) components express during the hypertrophic differentiation of chondrocytes and can modulate it, using ATDC5 cell line that involves differentiation from mesenchymal stem cells to ...
I. Tsukamoto, M. Akagi, S. Inoue, K. Yamagishi, S. Mori, S. Asada   +5 more
doaj   +1 more source