Results 11 to 20 of about 216,956 (381)
Cells, 2021 Articular cartilage is a connective tissue lining the surfaces of synovial joints. When the cartilage severely wears down, it leads to osteoarthritis (OA), a debilitating disease that affects millions of people globally.
A. Sebastian +6 more
semanticscholar +1 more source
Frontiers in Genetics, 2021 Kashin–Beck disease (KBD) mainly damages growth plate of adolescents and is susceptible to both gene and gene–environmental risk factors. HT-2 toxin, which is a primary metabolite of T-2 toxin, was regarded as one of the environmental risk factors of KBD.
Yanan Zhang +15 more
doaj +1 more source
LDHA-mediated ROS generation in chondrocytes is a potential therapeutic target for osteoarthritis
Nature Communications, 2020 The contribution of inflammation to the chronic joint disease osteoarthritis (OA) is unclear, and this lack of clarity is detrimental to efforts to identify therapeutic targets.
Manoj Arra +11 more
semanticscholar +1 more source
The emerging chondrocyte channelome [PDF]
Frontiers in Physiology, 2010 Chondrocytes are the resident cells of articular cartilage and are responsible for synthesizing a range of collagenous and non-collagenous extracellular matrix macromolecules. Whilst chondrocytes exist at low densities in the tissue (1-10% of the total tissue volume in mature cartilage) they are extremely active cells and are capable of responding to a
Barrett-Jolley, R +3 more
openaire +6 more sources
Chondrocytes in the resting zone of the growth plate are maintained in a Wnt-inhibitory environment
eLife, 2021 Chondrocytes in the resting zone of the postnatal growth plate are characterized by slow cell cycle progression, and encompass a population of parathyroid hormone-related protein (PTHrP)-expressing skeletal stem cells that contribute to the formation of ...
Shawn A Hallett +10 more
doaj +1 more source
Applied Sciences, 2022 The aim of the study was to assess the effects of therapeutic ultrasound (US) on oxidative stress (OS)-induced changes in cultured human chondrocytes (HCH). For this, monolayer HCH were randomized in three groups: a control group (CG), a group exposed to
Rodica Ana Ungur +14 more
doaj +1 more source
Chondrocytes isolation from hyaline cartilage by continuous monitoring method [PDF]
The Moldovan Medical Journal, 2021 Background: Articular cartilage has poor regenerative capacities. Numerous cartilage repair techniques are known, including implantation of autologous chondrocytes.
Vitalie Cobzac +3 more
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The chondrocyte primary cilium [PDF]
Osteoarthritis and Cartilage, 2014 The presence and role of primary, or non-motile, cilia on chondrocytes has confused cartilage researchers for decades. Initial explanations attributed a vestigial nature to chondrocyte cilia. Evidence is now emerging that supports the role of the chondrocyte primary cilium as a sensory organelle, in particular, in mechanotransduction and as a ...
K. Marberry, R. Ruhlen
openaire +3 more sources
Mechanics of chondrocyte hypertrophy [PDF]
Biomechanics and Modeling in Mechanobiology, 2011 Chondrocyte hypertrophy is a characteristic of osteoarthritis and dominates bone growth. Intra- and extracellular changes that are known to be induced by metabolically active hypertrophic chondrocytes are known to contribute to hypertrophy. However, it is unknown to which extent these mechanical conditions together can be held responsible for the total
van Cc René Donkelaar, W Wouter Wilson
openaire +4 more sources
npj Regenerative Medicine, 2021 Osteoarthritis (OA) causes serious changes in the metabolic and signaling pathways of chondrocytes, including the mitogen-activated protein kinase (MAPK) pathway.
Sunghyun Park +6 more
doaj +1 more source