Results 11 to 20 of about 213,570 (404)
ON THE SITE OF SULFATION IN THE CHONDROCYTE [PDF]
The Journal of Cell Biology, 1964 As observed autoradiographically in the cartilage of embryonic rats, radiosulfate is bound and concentrated only in vesicles of the juxtanuclear Golgi apparatus of secreting chondrocytes within 3 minutes of its presentation. From this area, vacuoles migrate peripherally and lodge in the subcortex; their sulfated contents are thence discharged via ...
Gabriel C. Godman, Nathan Lane
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Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance Osteoarthritis is a global health problem that affects load-bearing joints, causing loss of mobility and enormous healthcare costs. However, disease-modifying approaches are lacking.
Whasil Lee +9 more
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Journal of Cellular and Molecular Medicine, 2021 Temporomandibular joint (TMJ) osteoarthritis is a common chronic degenerative disease of the TMJ. In order to explore its aetiology and pathological mechanism, many animal models and cell models have been constructed to simulate the pathological process ...
Baochao Li +4 more
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Cells, 2021 Articular cartilage is a connective tissue lining the surfaces of synovial joints. When the cartilage severely wears down, it leads to osteoarthritis (OA), a debilitating disease that affects millions of people globally.
A. Sebastian +6 more
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LDHA-mediated ROS generation in chondrocytes is a potential therapeutic target for osteoarthritis
Nature Communications, 2020 The contribution of inflammation to the chronic joint disease osteoarthritis (OA) is unclear, and this lack of clarity is detrimental to efforts to identify therapeutic targets.
Manoj Arra +11 more
semanticscholar +1 more source
Applied Sciences, 2022 The aim of the study was to assess the effects of therapeutic ultrasound (US) on oxidative stress (OS)-induced changes in cultured human chondrocytes (HCH). For this, monolayer HCH were randomized in three groups: a control group (CG), a group exposed to
Rodica Ana Ungur +14 more
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Chondrocytes isolation from hyaline cartilage by continuous monitoring method [PDF]
The Moldovan Medical Journal, 2021 Background: Articular cartilage has poor regenerative capacities. Numerous cartilage repair techniques are known, including implantation of autologous chondrocytes.
Vitalie Cobzac +3 more
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The chondrocyte primary cilium [PDF]
Osteoarthritis and Cartilage, 2014 The presence and role of primary, or non-motile, cilia on chondrocytes has confused cartilage researchers for decades. Initial explanations attributed a vestigial nature to chondrocyte cilia. Evidence is now emerging that supports the role of the chondrocyte primary cilium as a sensory organelle, in particular, in mechanotransduction and as a ...
K. Marberry, R. Ruhlen
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Mechanics of chondrocyte hypertrophy [PDF]
Biomechanics and Modeling in Mechanobiology, 2011 Chondrocyte hypertrophy is a characteristic of osteoarthritis and dominates bone growth. Intra- and extracellular changes that are known to be induced by metabolically active hypertrophic chondrocytes are known to contribute to hypertrophy. However, it is unknown to which extent these mechanical conditions together can be held responsible for the total
van Cc René Donkelaar, W Wouter Wilson
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