Results 21 to 30 of about 99,218 (314)

Autologous Chondrocyte Implantation [PDF]

JBJS Essential Surgical Techniques, 2016
Autologous chondrocyte implantation (ACI) for the treatment of articular cartilage lesions of the knee joint provides successful and durable long-term outcomes.Obtain standing radiographs and magnetic resonance imaging (MRI) scans to identify all associated abnormalities (background factors).Evaluate the knee joint systematically and harvest cartilage ...
Tom, Minas, Takahiro, Ogura, Tim, Bryant
openaire   +2 more sources

Optimization of TGF-β1-transduced chondrocytes for cartilage regeneration in a 3D printed knee joint model.

PLoS ONE, 2019
A cell therapy product of transforming growth factor (TGF)-β1-transduced chondrocytes has been commercialized to treat osteoarthritis of the knee via intra-articular injection.
Jiyong Ahn, Seon Ae Kim, Ki Won Kim, Joon Hyuck Oh, Seok Jung Kim   +4 more
doaj   +1 more source

The emerging chondrocyte channelome [PDF]

Frontiers in Physiology, 2010
Chondrocytes are the resident cells of articular cartilage and are responsible for synthesizing a range of collagenous and non-collagenous extracellular matrix macromolecules. Whilst chondrocytes exist at low densities in the tissue (1-10% of the total tissue volume in mature cartilage) they are extremely active cells and are capable of responding to a
Barrett-Jolley, R, Lewis, R, Fallman, R, Mobasheri, A   +3 more
openaire   +5 more sources

ATG5 regulates type Ⅱ collagen expression by modulation of autophagy

陆军军医大学学报, 2023
Objective To explore the regulative effect of autophagy-related protein ATG5 on the expression of type Ⅱ collagen in human chondrocytes through affecting autophagy function.
DENG Lin, XIAN Menglin, YANG Yuyou
doaj   +1 more source

Autophagy plays a protective role in advanced glycation end products- induced apoptosis of chondrocytes via regulation of tumor necrosis factor-α , nuclear factor-κ B and reactive oxygen species

Asian Pacific Journal of Tropical Medicine, 2018
Objective: To study the adverse effects of advanced glycation end products (AGEs) on chondrocytes and the role of autophagy in this process. Methods: Chondrocytes were harvested from the human articular cartilage tissues in surgery.
Zhi-Jiang Sun, Ya-Yi Xia
doaj   +1 more source

The β-catenin/TCF-4 pathway regulates the expression of OPN in human osteoarthritic chondrocytes

Journal of Orthopaedic Surgery and Research, 2020
Background Cartilage destruction is the main characteristic of osteoarthritis (OA), and osteopontin (OPN) is elevated in OA articular cartilage; however, the reason for the increased OPN level is not determined.
Jian Tian, Shu-Guang Gao, Yu-Sheng Li, Chao Cheng, Zhen-Han Deng, Wei Luo, Fang-Jie Zhang   +6 more
doaj   +1 more source

Immunological Response against Allogeneic Chondrocytes Transplanted into Joint Surface Defects in Rats

Cell Transplantation, 1997
Rat chondrocytes isolated from the articular–epiphyseal cartilage complex were transplanted into defects prepared in articular cartilage and subchondral bone. Transplants were taken for examination after 3 and 8 wk.
Anna Hyc, Jacek Malejczyk, Anna Osiecka, Stanislaw Moskalewski   +3 more
doaj   +1 more source

Effects of cell phenotype and seeding density on the chondrogenic capacity of human osteoarthritic chondrocytes in type I collagen scaffolds

Journal of Orthopaedic Surgery and Research, 2020
Objective Matrix-associated autologous chondrocyte implantation (MACI) achieves good clinical efficacy in young patients with focal cartilage injury; however, phenotypic de-differentiation of chondrocytes cultured in monolayer and the treatment of older ...
Chenxi Cao, Yujun Zhang, Yanqi Ye, Tiezheng Sun   +3 more
doaj   +1 more source

Pathogenetic features of experimental osteoarthrosis induced by dexamethasone and talc

Бюллетень сибирской медицины, 2022
The aim of the study was to investigate the pathogenesis of experimental osteoarthrosis induced by dexamethasone and talc by examining the structure and defining the morphometric and metabolic features of knee joint skeletal connective tissues in rats ...
E. V. Gladkova
doaj   +1 more source

Composite Electrospun Fibers Containing Optimized B‐ and Cu‐Doped Bioactive Glass Sol‐Gel Particles for Potential Soft Tissue Engineering Applications

Advanced Engineering Materials, EarlyView.
This article describes the preparation and characterization of poly(ε‐caprolactone) electrospun composite fibers incorporating sol‐gel‐derived bioactive glass particles doped with B and Cu. Scanning electron microscopy, energy‐dispersive X‐ray spectroscopy, Fourier‐transform infrared spectroscopy, contact angle, acellular bioactivity, mechanical and ...
Elisa Piatti, Marta Miola, Liliana Liverani, Paolo Sartori, Enrica Verné, Aldo R. Boccaccini   +5 more
wiley   +1 more source