npj Regenerative Medicine, 2021 Osteoarthritis (OA) causes serious changes in the metabolic and signaling pathways of chondrocytes, including the mitogen-activated protein kinase (MAPK) pathway.
Sunghyun Park +6 more
doaj +1 more source
Premature cellular senescence in isolated chondrocytes from polydactyl cartilage in FBS containing serum in comparison to human serum [PDF]
مجله پزشکی دانشگاه علوم پزشکی تبریز, 2022 Background. Transplantation of chondrocytes is one of the methods for treatment of articular cartilage defects. For this purpose, it is necessary to isolate these chondrocytes and expand in serum containing culture medium.
Hajar Shafaei +3 more
doaj +1 more source
In vitro and in vivo validation of human and goat chondrocyte labeling by green fluorescent protein lentivirus transduction [PDF]
, 2010 We investigated whether human articular chondrocytes can be labeled efficiently and for long-term with a green fluorescent protein (GFP) lentivirus and whether the viral transduction would influence cell proliferation and tissue-forming capacity.
Acharya, Chitrangada +9 more
core +1 more source
Rapamycin protects chondrocytes against IL-18-induced apoptosis and ameliorates rat osteoarthritis
Aging, 2020 Interleukin 18 (IL-18) promotes inflammation and apoptosis in chondrocytes, thereby contributing to the development and progression of osteoarthritis (OA).
Jia-peng Bao +4 more
semanticscholar +1 more source
Chinese Medical Journal, 2021 . Background. Previous studies have reported that mitochondrial dysfunction participates in the pathological process of osteoarthritis (OA). However, studies that improve mitochondrial function are rare in OA. Mitochondrial transfer from mesenchymal stem
Rui Wang +5 more
doaj +1 more source
Detection and characterization of Sp1 binding activity in human chondrocytes and its alterations during chondrocyte dedifferentiation. [PDF]
, 1997 We have detected DNA binding activity for a synthetic oligonucleotide containing an Sp1 consensus sequence in nuclear extracts from human chondrocytes. Changes in the levels of Sp1 oligonucleotide binding activity were examined in nuclear extracts from ...
Dharmavaram, Rita M. +3 more
core +2 more sources
Comparison of Apoptosis and Autophagy in Human Chondrocytes Induced by the T-2 and HT-2 Toxins
Toxins, 2019 In this report, we have investigated the apoptosis and autophagy of chondrocytes induced by the T-2 and HT-2 toxins. The viability of chondrocytes was measured by the MTT assay.
Fang-Fang Yu +4 more
doaj +1 more source
Expression patterns of chondrocyte genes cloned by differential display in tibial dyschondroplasia [PDF]
, 2000 Tibial dyschondroplasia (TD) appears to involve a failure of the growth plate chondrocytes within growing long bones to differentiate fully to the hypertrophic stage, resulting in a mass of prehypertrophic chondrocytes which form the avascular TD lesion.
Botman, M +6 more
core +1 more source
Runx2 is essential for the transdifferentiation of chondrocytes into osteoblasts
PLoS Genetics, 2020 Chondrocytes proliferate and mature into hypertrophic chondrocytes. Vascular invasion into the cartilage occurs in the terminal hypertrophic chondrocyte layer, and terminal hypertrophic chondrocytes die by apoptosis or transdifferentiate into osteoblasts.
Xin Qin +10 more
semanticscholar +1 more source
Frontiers in Bioengineering and Biotechnology, 2021 Autologous chondrocyte implantation (ACI) is a procedure used to treat articular cartilage injuries and prevent the onset of post-traumatic osteoarthritis.
Yuzhao Huang +7 more
doaj +1 more source