Results 121 to 130 of about 93,694 (356)
Electronic Journal of Biotechnology, 2017 Background: C4ST-1 catalyzes the transfer of sulfate groups in the sulfonation of chondroitin during chondroitin sulfate synthesis. Chondroitin sulfate consists of numerous copies of negatively charged sulfonic acid groups that participate in the ...
Qingheng Wang +7 more
doaj +1 more source
Cellular internalization of alpha-synuclein aggregates by cell surface heparan sulfate depends on aggregate conformation and cell type. [PDF]
, 2017 Amyloid aggregates found in the brain of patients with neurodegenerative diseases, including Alzheimer's and Parkinson's disease, are thought to spread to increasingly larger areas of the brain through a prion-like seeding mechanism.
Esko, Jeffrey D +5 more
core +2 more sources
Biotechnology Progress, EarlyView.Abstract The last two decades, between 2000 and 2024, significant steps were achieved regarding the interaction between various stem cells and titanium implant surfaces to improve dental implant integration. This literature review focuses on the potential effects of (i) bone marrow mesenchymal stem cells (BMSCs), (ii) periodontal ligament stem cells ...
Ioannis Tsamesidis +4 more
wiley +1 more source
How Growth Cones Sense Extracellular Cues and Drive Neuronal Migration: Shared Mechanisms Between Growth Cones of Migrating Neurons and Axons. [PDF]
BioessaysMigrating neurons and growing axons utilize structurally and functionally similar growth cones to detect guidance cues. Shared receptors and signaling pathways mediate cytoskeletal reorganization to direct movement. This conserved mechanism underlies both neuronal migration and axon extension, providing insights into neuronal development and potential ...
Kanzawa T +3 more
europepmc +2 more sources
Harnessing chimeric antigen receptor macrophages against solid tumors
Cancer Communications, EarlyView.Abstract Macrophages are prevalent in multiple tumors and exhibit diverse and potent functional activities. Therapeutic reprogramming of macrophage phenotypes represents a promising strategy for cancer immunotherapy. Engineering chimeric antigen receptors (CARs) to endow macrophages with anti‐tumor capacities demonstrated encouraging efficacy ...
Mengru Wang +3 more
wiley +1 more source
The role of proteases in pathologies of the synovial joint [PDF]
, 2008 Synovial (diarthrodial) joints are employed within the body to provide skeletal mobility and have a characteristic structure adapted to provide a smooth almost frictionless surface for articulation.
Buttle, D, Jones, GC, Riley, GP
core +1 more source
Holothurian Fucosylated Chondroitin Sulfate [PDF]
Marine Drugs, 2014 Fucosylated chondroitin sulfate (FucCS) is a structurally distinct glycosaminoglycan found in sea cucumber species. It has the same backbone composition of alternating 4-linked glucuronic acid and 3-linked N-acetyl galactosamine residues within disaccharide repeating units as regularly found in mammalian chondroitin sulfates.
openaire +4 more sources
Glycosaminoglycans as Polyelectrolytes: Charge, Interactions, and Applications
ChemBioChem, EarlyView.Glycosaminoglycans (GAGs) are linear, anionic biopolymers with their functions tightly linked to their charge. This review approaches GAGs from a polyelectrolyte perspective, shedding light on how the distribution of sulfate groups and, thus, negative charges, governs their interactions with other biomolecules.
Gergo Peter Szekeres +7 more
wiley +1 more source
Isolation of an
Microbial Cell Factories, 2010 Background Chondroitin sulphate is a complex polysaccharide having important structural and protective functions in animal tissues. Extracted from animals, this compound is used as a human anti-inflammatory drug.
De Rosa Mario +7 more
doaj +1 more source
Nanomaterial‐Based Precision Medicine for Breast Cancer Diagnosis and Treatment
ChemNanoMat, EarlyView.This research emphasizes the use of targeted precision medicine in the treatment of breast cancer. Through the integration of diagnosis and therapeutic delivery, nanocarriers are designed to selectively target cancer cells, preserving healthy tissue, thereby improving treatment effectiveness and reducing side effects.
Tanaka Ndongwe +8 more
wiley +1 more source