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Nature CommunicationsEpithelial cells are the first point of contact for bacteria entering the respiratory tract. Streptococcus pneumoniae is an obligate human pathobiont of the nasal mucosa, carried asymptomatically but also the cause of severe pneumoniae.
Christine Chevalier +5 more
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Molecular Cell, 2002 How the transcriptional apparatus gains access to and subsequently opens compacted chromatin has remained a mystery. Now in this issue of Molecular Cell, Zaret and coworkers show that chromatin opening in vitro is not mediated by the classical chromatin remodeling machines but instead occurs through specific transcription factor-histone interactions.
Lomvardas, Stavros, Thanos, Dimitris
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Structural basis of cyclobutane pyrimidine dimer recognition by UV-DDB in the nucleosome
Nature CommunicationsIn mammalian global genomic nucleotide excision repair, UV-DDB plays a central role in recognizing DNA lesions, such as 6-4 photoproducts and cyclobutane pyrimidine dimers, within chromatin.
Syota Matsumoto +10 more
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Genome Biology, 2020 Background Chromosomes are subdivided spatially to delimit long-range interactions into topologically associating domains (TADs). TADs are often flanked by chromatin insulators and transcription units that may participate in such demarcation. Remarkably,
Alexandre Heurteau +6 more
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Cantharidin downregulates PSD1 expression and inhibits autophagic flux in yeast cells
FEBS Open Bio, 2022 Cantharidin is a terpenoid compound of insect origin, naturally produced by male blister beetles as an antipredatory mechanism. Cantharidin has anticancer properties, which are attributed to its ability to induce cell cycle arrest, DNA damage, MAPK ...
Swati Swagatika, Raghuvir Singh Tomar
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Chromatin Unlimited: An Evolutionary View of Chromatin [PDF]
Epigenomes, 2022 Chromatin is a fundamental and highly conserved structure that carries genetic and epigenetic information in eukaryotic cells [...]
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An HP1 isoform-specific feedback mechanism regulates Suv39h1 activity under stress conditions
Epigenetics, 2017 The presence of H3K9me3 and heterochromatin protein 1 (HP1) are hallmarks of heterochromatin conserved in eukaryotes. The spreading and maintenance of H3K9me3 is effected by the functional interplay between the H3K9me3-specific histone methyltransferase ...
Helena Raurell-Vila +9 more
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PLoS ONE, 2012 In living cells, DNA is packaged along with protein and RNA into chromatin. Chemical modifications to nucleotides and histone proteins are added, removed and recognized by multi-functional molecular complexes. Here I define a new computational model, in which chromatin modifications are information units that can be written onto a one-dimensional ...
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Statins as anti‐tumor agents: A paradigm for repurposed drugs
Cancer ReportsBackground Statins, frequently prescribed medications, work by inhibiting the rate‐limiting enzyme HMG‐CoA reductase (HMGCR) in the mevalonate pathway to reduce cholesterol levels.
Sneha Tripathi +2 more
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Structural basis of RNAPII transcription on the nucleosome containing histone variant H2A.B
The EMBO JournalH2A.B is a distant histone H2A variant associated with actively transcribed regions of the genome, suggesting its positive role in promoting transcription.
Munetaka Akatsu +7 more
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