Results 1 to 10 of about 452,870 (322)
Fun30 and Rtt109 Mediate Epigenetic Regulation of the DNA Damage Response Pathway in C. albicans
Journal of Fungi, 2022 Fun30, an ATP-dependent chromatin remodeler from S. cerevisiae, is known to mediate both regulation of gene expression as well as DNA damage response/repair. The Fun30 from C. albicans has not yet been elucidated. We show that C.
Prashant Kumar Maurya +10 more
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Histone H4 lysine 16 acetylation controls central carbon metabolism and diet-induced obesity in mice
Nature Communications, 2021 Misregulation of chromatin has been linked to many conditions, including obesity, but the details remain unclear. Here the authors identify the H4 lysine 16 acetyltransferase MOF as a master regulator of glucose metabolism that is required for normal ...
Cecilia Pessoa Rodrigues +6 more
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Aging is associated with increased chromatin accessibility and reduced polymerase pausing in liver
Molecular Systems Biology, 2022 Regulation of gene expression is linked to the organization of the genome. With age, chromatin alterations occur on all levels of genome organization, accompanied by changes in the gene expression profile.
Mihaela Bozukova +5 more
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Biotechnology & Biotechnological Equipment, 2021 In the recent years, the application of new antitumor drugs has focused on the replacement of conventional chemotherapeutics with compounds derived from natural products.
Jordana Todorova +4 more
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Frontiers in Cell and Developmental Biology, 2023 In vitro cell line model systems are essential in supporting the research community due to their low cost, uniform culturing conditions, homogeneous biological resources, and easy experimental design to study the cause and effect of a gene or a molecule.
Jhinuk Basu +14 more
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Epigenetics & Chromatin, 2021 Background H1T2/H1FNT is a germ cell-specific linker histone variant expressed during spermiogenesis specifically in round and elongating spermatids. Infertile phenotype of homozygous H1T2 mutant male mice revealed the essential function of H1T2 for the ...
Vasantha Shalini +4 more
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Nature Communications, 2023 Rhodamines are privileged fluorescent dyes for labelling intracellular structures in living cells. Here, the authors present a facile protecting-group-free synthesis permitting generation of a wide range of symmetrical and unsymmetrical 4 ...
Jonas Bucevičius +6 more
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Regulation of the SUV39H Family Methyltransferases: Insights from Fission Yeast
Biomolecules, 2023 Histones, which make up nucleosomes, undergo various post-translational modifications, such as acetylation, methylation, phosphorylation, and ubiquitylation. In particular, histone methylation serves different cellular functions depending on the location
Rinko Nakamura, Jun-ichi Nakayama
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Targeting the Nucleosome Acidic Patch by Viral Proteins: Two Birds with One Stone?
mBio, 2022 The past decade illuminated the H2A-H2B acidic patch as a cornerstone for both nucleosome recognition and chromatin structure regulation. Higher-order folding of chromatin arrays is mediated by interactions of histone H4 tail with an adjacent nucleosome ...
Floriane Lagadec +2 more
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Structural basis of RNA polymerase II transcription on the chromatosome containing linker histone H1
Nature Communications, 2022 The mechanism by which RNAPII transcribes the DNA in the chromatosome with H1 has remained enigmatic. Here the authors present the cryo-EM structures of the RNAPII-chromatosome complexes, and explain how RNAPII is regulated by H1 in chromatin.
Rina Hirano +6 more
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