Results 11 to 20 of about 2,366 (155)

Chrysophanol: A Natural Anthraquinone with Multifaceted Biotherapeutic Potential [PDF]

Biomolecules, 2019
Chrysophanol is a unique anthraquinone having broad-spectrum therapeutic potential along with ecological importance. It is the first polyketide that has been reported to be biosynthesized in an organism-specific manner. The traditional Chinese and Korean
Prateeksha, Mohd Aslam Yusuf, Brahma N. Singh, Surya Sudheer, Ravindra N. Kharwar, Saba Siddiqui, Ahmed M. Abdel-Azeem, Leonardo Fernandes Fraceto, Kavya Dashora, Vijai K. Gupta   +9 more
doaj   +4 more sources

Novel protein photocleavers: Chrysophanol and pachybasin

Journal of Photochemistry and Photobiology, 2020
This study investigates the photocleavage activity of two anthraquinone derivatives isolated from T. harzianum ETS 323, chrysophanol and pachybasin, upon proteins.
Kou-Cheng Peng, Kun-Che Chang, Shyue-Chu Ke, JunRu Chen, Shu-Ying Liu   +4 more
doaj   +4 more sources

Chrysophanol protects against doxorubicin-induced cardiotoxicity by suppressing cellular PARylation

Acta Pharmaceutica Sinica B, 2019
The clinical application of doxorubicin (DOX) in cancer chemotherapy is limited by its life-threatening cardiotoxic effects. Chrysophanol (CHR), an anthraquinone compound isolated from the rhizome of Rheum palmatum L., is considered to play a broad role ...
Jing Lu, Jingyan Li, Yuehuai Hu, Zhen Guo, Duanping Sun, Panxia Wang, Kaiteng Guo, Dayue Darrel Duan, Si Gao, Jianmin Jiang, Junjian Wang, Peiqing Liu   +11 more
doaj   +3 more sources

Realgar-Induced CNS Toxicity: Exploring OTC-Mediated Ornithine Regulation of ZBTB7A Inhibits Astrocyte Glycolysis Based on the Liver-Brain Axis. [PDF]

Adv Sci (Weinh)
Arsenic in realgar induces CNS toxicity through direct and indirect effects: it activates ZBTB7A in astrocytes, which in turn inhibits glycolysis and impairs mice's learning, memory, and exploration; it also suppresses OTC in the liver to block the ornithine cycle, leading to blood ornithine accumulation that crosses into the frontal lobe and further ...
Ye P, Li Z, Fu H, Wang S, Cui X, Song C, Ma C, Jiang H.   +7 more
europepmc   +2 more sources

<i>Rumex</i> Species: Phytochemistry, Pharmacology and Nutritional Potential for Food and Health Applications. [PDF]

Food Sci Nutr
Rumex dentatus, R. vesicarius, and Emex spinosa are traditionally used for managing gastrointestinal, respiratory, hepatic, and inflammatory disorders. In addition to their ethnomedicinal value, some species are consumed as wild edibles. Pharmacological studies support their antimicrobial, antioxidant, hepatoprotective, cytotoxic, and antidiabetic ...
Mohamed Gohar M, Ezzat SM, Yeskaliyeva B, Elhawary SS, Kirollos FN, Khouchlaa A, Bouyahya A, Calina D, Sharifi-Rad J, Setzer WN, Martorell M.   +10 more
europepmc   +2 more sources

Nephroprotective Role of Chrysophanol in Hypoxia/Reoxygenation-Induced Renal Cell Damage via Apoptosis, ER Stress, and Ferroptosis

Biomedicines, 2021
Acute kidney injury (AKI) is caused by hypoxia-reoxygenation (H/R), which is a kidney injury produced by a variety of causes, resulting in the remaining portion of the kidney function being unable to maintain the balance for performing the tasks of waste
Chih-Hung Lin, Han-Fang Tseng, Po-Chun Hsieh, Valeria Chiu, Ting-Yun Lin, Chou-Chin Lan, I-Shiang Tzeng, Huan-Nung Chao, Chia-Chen Hsu, Chan-Yen Kuo   +9 more
doaj   +1 more source

Chrysophanol Suppresses Cell Growth via mTOR/PPAR-α Regulation and ROS Accumulation in Cultured Human Tongue Squamous Carcinoma SAS Cells

Current Issues in Molecular Biology, 2022
Oral cancer, a type of head and neck cancer, can pose a significant risk of death unless diagnosed and treated early. Alternative treatments are urgently needed owing to the high mortality rate, limitations of conventional treatments, and many ...
Po-Chih Hsu, Chia-Chen Hsu, Yi-Jan Hsia, Chan-Yen Kuo   +3 more
doaj   +1 more source

Chrysophanol: a review of its pharmacology, toxicity and pharmacokinetics [PDF]

Journal of Pharmacy and Pharmacology, 2019
Abstract Objective Chrysophanol is a natural anthraquinone, also known as chrysophanic acid and 1,8-dihydroxy-3-methyl-anthraquinone. It has been widely used in the food and pharmaceutical fields.
Long Xie, Hailong Tang, Jiawen Song, Jiaying Long, Linlin Zhang, Xiaofang Li   +5 more
openaire   +2 more sources

The pharmacological properties of chrysophanol, the recent advances

Biomedicine & Pharmacotherapy, 2020
As a universal Chinese medicine, Rhei Radix et Rhizoma was used for centuries in different fields including pharmaceutical, health care and cosmetics. Chrysophanol (Chr) is one of the most important anthraquinone components isolated from plants of the Rheum genus.
Siyu, Su, Jiasi, Wu, Yue, Gao, Yu, Luo, Dong, Yang, Ping, Wang   +5 more
openaire   +2 more sources

Chrysophanol Induced Glioma Cells Apoptosis via Activation of Mitochondrial Apoptosis Pathway [PDF]

Bioengineered, 2021
Glioma is a common intracranial tumor originated from neuroglia cell. Chrysophanol is an anthraquinone derivative proved to exert anticancer effects in various cancers. This paper investigated the effect and mechanism of chrysophanol in glioma. Glioma cell lines U251 and SHG-44 were adopted in the experiments.
Jia Gu, Sunil Rauniyar, Yan Wang, Wenjian Zhan, Chengkun Ye, Shaogan Ji, Guanzheng Liu   +6 more
openaire   +2 more sources