Results 21 to 30 of about 2,366 (155)

In Vitro, Molecular Docking and In Silico ADME/Tox Studies of Emodin and Chrysophanol against Human Colorectal and Cervical Carcinoma

Pharmaceuticals, 2022
Anthraquinones (AQs) are present in foods, dietary supplements, pharmaceuticals, and traditional treatments and have a wide spectrum of pharmacological activities. In the search for anti-cancer drugs, AQ derivatives are an important class. In this study,
Wasim Ahmad, Mohammad Azam Ansari, Abdulrhman Alsayari, Dalia Almaghaslah, Shadma Wahab, Mohammad N. Alomary, Qazi Mohammad Sajid Jamal, Firdos Alam Khan, Abuzer Ali, Prawez Alam, Abozer Y. Elderdery   +10 more
doaj   +1 more source

Chrysophanol attenuates hepatitis B virus X protein-induced hepatic stellate cell fibrosis by regulating endoplasmic reticulum stress and ferroptosis

Journal of Pharmacological Sciences, 2020
Hepatitis B virus X protein (HBx) and hepatic stellate cells (HSCs) are critical for liver fibrosis development. Anti-fibrosis occurs via reversion to quiescent-type HSCs or clearance of HSCs via apoptosis or ferroptosis.
Chan-Yen Kuo, Valeria Chiu, Po-Chun Hsieh, Chun-Yen Huang, S. Joseph Huang, I-Shiang Tzeng, Fu-Ming Tsai, Mao-Liang Chen, Chien-Ting Liu, Yi-Ru Chen   +9 more
doaj   +1 more source

The prospects and potential of the horticultural and pharmacological medicinal herb senna (Cassia angustifolia Vahl.): A review

Technology in Horticulture, 2023
The dried leaves and pods of Cassia L., a member of the Caesalpinioideae subfamily of the Fabaceae family and the Cassiinae sub-tribe are called 'senna drug'.
Raj Kishori Lal, Chandan Singh Chanotiya, Ashish Kumar   +2 more
doaj   +1 more source

One-pot Synthesis of N-doped Reduced Graphene Oxide Decorated with Au-Pd@Au Alloy Nanodendrites for Electrochemical Detection of Chrysophanol

International Journal of Electrochemical Science, 2020
We demonstrate for the first time a new one-step effective route for the preparing of N-doped reduced graphene oxide loading with Au-Pd@Au (N-rGO-Au-Pd@Au) alloy nanodendrites. Then the prepared N-rGO-Au-Pd@Au alloy nanodendrites were used to fabricate a
Ling Shi, Ze-Feng Wang, Na Wu, Gao-Zhang Gou, Xian-Lan Chen, Guang-Ming Yang, Wei Liu   +6 more
doaj   +1 more source

Transcriptomic analysis reveals distinct resistant response by physcion and chrysophanol against cucumber powdery mildew [PDF]

PeerJ, 2016
Physcion and chrysophanol induce defense responses against powdery mildew in cucumbers. The combination of these two compounds has synergistic interaction against the disease.
Yanping Li, Shilin Tian, Xiaojun Yang, Xin Wang, Yuhai Guo, Hanwen Ni   +5 more
doaj   +2 more sources

Ultrastructural Changes of Sphaerotheca fuliginea (Schlechtend.:Fr.) Pollacci in Cucumber After Treated by Chrysophanol

Journal of Integrative Agriculture, 2012
Chrysophanol (1,8-dihydroxy-3-methylanthraquinone) is a free anthraquinone compound and a secondary metabolite of medicinal plant rhubarb. Chrysophanol has been reported to have both protective and curative activity against Sphaerotheca fuliginea ...
Hong-min REN, Fan FAN, Ke-qiang CAO
doaj   +1 more source

Chrysophanol Exerts Anti-inflammatory Activity by Targeting Histone Deacetylase 3 Through the High Mobility Group Protein 1-Nuclear Transcription Factor-Kappa B Signaling Pathway in vivo and in vitro

Frontiers in Bioengineering and Biotechnology, 2021
Chrysophanol (Chr) is the main monomer isolated from Rheum rhabarbarum. This study aimed to identify the potential in vitro and in vivo cytoprotective effects of Chr on lipopolysaccharide (LPS)-triggered acute lung injury (ALI).
Quan Wen, Quan Wen, Ngaikeung Lau, Huandi Weng, Peng Ye, Shaohui Du, Chun Li, Jianping Lv, Hui Li   +8 more
doaj   +1 more source

Mutagenicity of islandicin and chrysophanol in the Salmonella/microsome system [PDF]

Applied and Environmental Microbiology, 1980
Chrysophanol and islandicin, two anthraquinones which are structurally related to emodin, were found to be frame-shift mutagens for Salmonella typhimurium strain TA 1537 after metabolic activation.
D F, Liberman, F L, Schaefer, R C, Fink, M, Ramgopal, A C, Ghosh, R, Mulcahy   +5 more
openaire   +2 more sources

Anti-Inflammatory Activity of Chrysophanol through the Suppression of NF-kB/Caspase-1 Activation in Vitro and in Vivo

Molecules, 2010
Chrysophanol is a member of the anthraquinone family and has multiple pharmacological effects, but the exact mechanism of the anti-inflammatory effects of chrysophanol has yet to be thoroughly elucidated.
Seung-Heon Hong, Jae-Young Um, Byong-Joo Lee, Dae-Hee Park, Min-Cheol Kim, Su-Jin Kim   +5 more
doaj   +1 more source

Chrysophanol Relieves Cisplatin-Induced Nephrotoxicity via Concomitant Inhibition of Oxidative Stress, Apoptosis, and Inflammation

Frontiers in Physiology, 2021
Cisplatin (CDDP) is one of the most frequently prescribed chemotherapy medications. However, its nephrotoxicity which often leads to acute kidney injury (AKI), greatly limits its clinical application.
Siqing Ma, Siqing Ma, Siqing Ma, Siqing Ma, Heng Xu, Weihua Huang, Weihua Huang, Weihua Huang, Weihua Huang, Yongchao Gao, Yongchao Gao, Yongchao Gao, Yongchao Gao, Honghao Zhou, Honghao Zhou, Honghao Zhou, Honghao Zhou, Xiong Li, Wei Zhang, Wei Zhang, Wei Zhang, Wei Zhang   +21 more
doaj   +1 more source