Results 91 to 100 of about 2,846 (197)

Integrin-Targeted Hybrid Fluorescence Molecular Tomography/X-ray Computed Tomography for Imaging Tumor Progression and Early Response in Non-Small Cell Lung Cancer

Neoplasia: An International Journal for Oncology Research, 2017
Integrins play an important role in tumor progression, invasion and metastasis. Therefore we aimed to evaluate a preclinical imaging approach applying ανβ3 integrin targeted hybrid Fluorescence Molecular Tomography/X-ray Computed Tomography (FMT-XCT) for
Xiaopeng Ma, Valerie Phi Van, Melanie A. Kimm, Jaya Prakash, Horst Kessler, Katja Kosanke, Annette Feuchtinger, Michaela Aichler, Aayush Gupta, Ernst J. Rummeny, Michel Eisenblätter, Jens Siveke, Axel K. Walch, Rickmer Braren, Vasilis Ntziachristos, Moritz Wildgruber   +15 more
doaj   +1 more source

Cilengitide induces Src-dependent phosphorylation of VE-cadherin cytoplasmic domain.

, 2013
(a) Western blotting analysis of VE-cadherin phosphorylation at tyrosine residues Y658 and Y731 and total VE-cadherin in HUVEC grown on fibronectin or collagen I and stimulated for 10 minutes with cilengitide (10 µM) or VEGF (100 ng/ml) in the presence ...
Gian Carlo Alghisi (374631), Curzio Rüegg (5520968), Lionel Ponsonnet (374632)   +2 more
core   +1 more source

Development and biological characterization of the cyclic peptide cRGDTFI with potent binding affinity for integrins αvβ3 and αvβ5

Materials & Design
The arginine-glycine-aspartic acid (RGD) sequence is a motif that binds to integrins. RGD-containing peptides have applications in cancer treatment, tissue engineering, drug delivery, and imaging. The potent RGD-containing peptides cilengitide (cRGDfMeV)
Yuji Yamada, Seiya Ohki, Masumi Matsunuma, Masaki Mishima, Mitsuhiro Takeda, Teppei Ikeya, Tomomi Furihata, Keisuke Hamada, Yamato Kikkawa, Motoyoshi Nomizu   +9 more
doaj   +1 more source

Cilengitide inhibits agarose spot invasion by H28 cells.

, 2014
(A) Mitotically inactivated cells were plated on wells with an agarose spot in medium ±1 µM cilengitide. After 1–2 days cells were fixed and stained with crystal violet and imaged with an EVOS-FL digital imaging system.
Glen Reid (207229), Ngan Ching Cheng (529790), Nico van Zandwijk (87878)   +2 more
core   +1 more source

Spatial confinement modulates endothelial cell behavior and traction force in 3D hydrogel microgrooves

Materials Today Bio
The mechanical environment of vascular endothelial cells (ECs) encompasses a wide range of curvatures due to variations in blood vessel diameters. Integrins, key mediators of cell-matrix interactions, establish connections between the extracellular ...
Wenli Jiang, Xinghong Yao, Jian Zhong, Zhi Ouyang, Junyi Shen, Yan Qiu, Ye Zeng   +6 more
doaj   +1 more source

Integrins as Therapeutic Targets for SARS-CoV-2

Frontiers in Cellular and Infection Microbiology, 2022
Timothy E. Gressett, Timothy E. Gressett, Timothy E. Gressett, Danielle Nader, Juan Pablo Robles, Tione Buranda, Steven W. Kerrigan, Gregory Bix, Gregory Bix, Gregory Bix   +9 more
doaj   +1 more source

Milk Fat Globule-EGF Factor 8 (MFGE8) Mitigates Cognitive Impairment in Rats with Sepsis-Associated Encephalopathy: An fMRI Study

Journal of Integrative Neuroscience
Background: Sepsis-associated encephalopathy (SAE) impairs hippocampal microglial efferocytosis, causing cognitive deficits. Previous research found that milk fat globule epidermal growth factor 8 protein (MFGE8) stimulates efferocytosis, reducing ...
Haojia Li, Hongsen Liao, Lu Sun, Dejian Chen, Yong Fei, Ming Yao, Bing Huang, Xiaoyan Guo, Shaozheng Song, Hongguang Bao   +9 more
doaj   +1 more source

Monocyte adhesion to atherosclerotic matrix proteins is enhanced by Asn-Gly-Arg deamidation

Scientific Reports, 2017
Atherosclerosis arises from leukocyte infiltration and thickening of the artery walls and constitutes a major component of vascular disease pathology, but the molecular events underpinning this process are not fully understood. Proteins containing an Asn-
Bamaprasad Dutta, Jung Eun Park, Subodh Kumar, Piliang Hao, Xavier Gallart-Palau, Aida Serra, Yan Ren, Vitaly Sorokin, Chuen Neng Lee, Hee Hwa Ho, Dominique de Kleijn, Siu Kwan Sze   +11 more
doaj   +1 more source

Effects of cilengitide on 3D invasion by MPM spheroids.

, 2014
Spheroids were embedded in collagen gel, overlaid with medium ±1 µM cilengitide and incubated at 37°C for 1–4 days. Spheroids were stained with calcein-AM or SYBR green and live images were captured.
Glen Reid (207229), Ngan Ching Cheng (529790), Nico van Zandwijk (87878)   +2 more
core   +1 more source

Randomized Phase II Study of Cilengitide, an Integrin-Targeting Arginine-Glycine-Aspartic Acid Peptide, in Recurrent Glioblastoma Multiforme

, 2008
Purpose Cilengitide, an inhibitor of αvβ3 and αvβ5 integrin receptors, demonstrated minimal toxicity and durable activity across a wide range of doses administered to adults with recurrent glioblastoma multiforme (GBM) in a prior phase I study.
Schiff, David, Ravin, Paula, Burdette-Radoux, Susan, Fink, Karen L., Raizer, Jeffrey J., Plotkin, Scott, O, Alison, Shapiro, William R., Nabors, L. Burt, Rich, Keith M., Mikkelsen, Tom, Dropcho, Edward J., Reardon, David, Glantz, Michael, Picard, Martin, Nippgen, Johannes, Cloughesy, Timothy F., Wittemer, Sabine M.   +17 more
core   +1 more source