Results 101 to 110 of about 2,846 (197)

Cilengitide treatment of newly diagnosed glioblastoma patients does not alter patterns of progression [PDF]

, 2019
The integrin antagonist cilengitide has been explored as an adjunct with anti-angiogenic properties to standard of care temozolomide chemoradiotherapy (TMZ/RT→TMZ) in newly diagnosed glioblastoma.
Clément, Paul, Tonn, Jörg, Tabatabai, Ghazaleh, Eisele, Anna-Carina, Weller, Michael, Simon, Matthias, Nikkhah, Guido, Stupp, Roger, Wick, Wolfgang, Eisele, Günter, Wick, Antje, Schlegel, Uwe, Krex, Dietmar, Neyns, Bart, Picard, Martin, Ochsenbein, Adrian   +15 more
core  

Supplementary Figure 3 from The Integrin Inhibitor Cilengitide Affects Meningioma Cell Motility and Invasion

, 2013
Supplementary Figure 3 - PDF file 43K, Overall survival of mice treated with cilengitide and control ...
Jan-Peter Warnke (11091068), Peter Hass (659595), Annette Wilisch-Neumann (14988846), Werner EK Braunsdorf (14988855), Christian Mawrin (2102), Thomas Schneider (252444), Elmar Kirches (8669856), Doreen Pachow (14988852), Cornelia Helbing (14988861), Diana Pasemann (14988858), Nadine Kliese (14988849), Frank-Dietmar Böhmer (478219)   +11 more
core   +1 more source

Reduced Cytokine Release in Ex Vivo Response to Cilengitide and Cetuximab Is a Marker for Improved Survival of Head and Neck Cancer Patients

, 2017
Targeting of αVβ3 and αVβ5 integrins by cilengitide may reduce growth of solid tumors including head and neck squamous cell carcinoma (HNSCC). Preclinical investigations suggest increased activity of cilengitide in combination with other treatment ...
Susan Cedra, Marlen Kolb, Susanne Wiegand, Gunnar Wichmann, Andreas Dietz   +4 more
core   +1 more source

Novel strategies for enhanced fluorescence visualization of glioblastoma tumors based on HPMA copolymers conjugated with tumor targeting and/or cell‐penetrating peptides

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Nano‐sized polymer systems are often used as carriers for drugs and contrast agents to increase circulation time and solubility and to reduce possible side effects.
Eliška Grosmanová, Robert Pola, Marcela Filipová, Maxime Henry, Jean‐Luc Coll, Tomáš Etrych   +5 more
doaj   +1 more source

Src inhibition prevents cilengitide-induced relocalization of αVβ3 at the cell edge and disappearance of VE-cadherin from cellular junctions.

, 2013
(a) Subconfluent and confluent HUVEC cultured on fibronectin or collagen I were exposed for 20 minutes to cilengitide (10 µM) in the presence of absence of CGP77675 (2.5 µM) and stained for αVβ3.
Gian Carlo Alghisi (374631), Curzio Rüegg (5520968), Lionel Ponsonnet (374632)   +2 more
core   +1 more source

Cilengitide [PDF]

, 2020
openaire   +1 more source

Relative cell death of HUVEC cultures exposed to cilengitide or EMD135981.

, 2013
HUVEC were cultured for 18 hours on vitronectin (αVβ3 ligand), fibronectin (α5β1>αVβ3 ligand) and collagen I (α1β1 and α2β1 ligand) before they were exposed for 4 hours to EMD135981 or cilengitide.
Gian Carlo Alghisi (374631), Curzio Rüegg (5520968), Lionel Ponsonnet (374632)   +2 more
core   +1 more source

Inside a Metastatic Fracture: Molecular Bases and New Potential Therapeutic Targets

Cancer Medicine
Introduction Bone metastases and pathological fractures significantly impact the prognosis and quality of life in cancer patients. However, clinical and radiological features alone have been shown to fail to predict skeletal related events of a bone ...
Alessandro Bruschi, Andrea Sambri, Michele Fiore, Elisa Bubbico, Cristina Scollo, Andrea Pace, Renato Zunarelli, Andrea Montanari, Alberta Cappelli, Lorenzo Di Prinzio, Massimiliano De Paolis   +10 more
doaj   +1 more source

Salvianolic acid B attenuates liver fibrosis by targeting Ecm1 and inhibiting hepatocyte ferroptosis

Redox Biology
Hepatocyte ferroptosis promotes the pathogenesis and progression of liver fibrosis. Salvianolic acid B (Sal B) exerts antifibrotic effects. However, the pharmacological mechanism and target has not yet been fully elucidated. In this study, liver fibrosis
Yadong Fu, Xiaoxi Zhou, Lin Wang, Weiguo Fan, Siqi Gao, Danyan Zhang, Zhiyang Ling, Yaguang Zhang, Liyan Ma, Fang Bai, Jiamei Chen, Bing Sun, Ping Liu   +12 more
doaj   +1 more source

Cilengitide causes loss of αVβ3 from focal adhesions and promotes appearance of αVβ3 patches at the cell edge.

, 2013
HUVEC were plated on coverslips coated with fibronectin or collagen I and were treated with 10 µM of cilengitide for 20 minutes. The localization of the αVβ3 or β1 integrin (green) and paxillin (red) were monitored by immunofluorescence staining.
Gian Carlo Alghisi (374631), Curzio Rüegg (5520968), Lionel Ponsonnet (374632)   +2 more
core   +1 more source