Results 81 to 90 of about 2,846 (197)

The Differentiation of Pancreatic Tumor-Initiating Cells by Vitronectin Can Be Blocked by Cilengitide [PDF]

Pancreas, 2013
Pancreatic cancer is a leading cancer type and its molecular pathology is poorly understood. The only potentially curative therapeutic option available is complete surgical resection; however, this is inadequate as most of the patients are diagnosed at an advanced or metastatic stage.
Stephanie M, Cabarcas, Lei, Sun, Lesley, Mathews, Suneetha, Thomas, Xiaohu, Zhang, William L, Farrar   +5 more
openaire   +2 more sources

Targeting Microbiome Metabolites: Reshaping Immunotherapy and Clinical Management Strategies for Colorectal Cancer

iMetaMed, Volume 2, Issue 1, March 2026.
The occurrence and progression of colorectal cancer are intricately linked to metabolites produced by the gut microbiota. Metabolites generated by pathogenic microbial communities can promote colorectal cancer development by reshaping the immune microenvironment.
Xinrui Yang, Ke Zhang, Lijie Xia, Jinyao Li   +3 more
wiley   +1 more source

Metabolic reprogramming of efferocytosis in the tumour microenvironment: From apoptotic‐cell clearance to therapeutic targeting

Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.
This review systematically deconstructs the pathological efferocytic—metabolic axis in tumours, framing it as a three‐stage, self‐reinforcing cycle: from metabolite‐driven macrophage recruitment, through hijacked surface recognition, to post‐phagocytic metabolic reprogramming that locks in immunosuppression.
Qianlu Yang, Jie Yan, Qianxi Yang
wiley   +1 more source

Recent Advances in Bioconjugation of Aromatic Amino Acid Residues by a Reactivity‐Guided Approach

The Chemical Record, Volume 26, Issue 2, February 2026.
This review highlights recent advances in the bioconjugation of aromatic amino acids residues, focusing on strategies that leverage their inherent chemical reactivity to enable precise and versatile modifications of biomacromolecules, illustrating relevant applications.
Bruno M. da S. Santos, Lívia C. R. M. da Frota, Thais G. Silva, Fernanda G. Finelli   +3 more
wiley   +1 more source

Cancer Immunotherapy via Disruption of Integrin αvβ3 and CD47 Costabilization on Cancer Cell Surface

Advanced Science, Volume 13, Issue 2, 9 January 2026.
This study identifies a cancer‐specific interaction between CD47 and integrin αvβ3 that facilitates immune evasion. A rationally designed peptide, PSFL‐NK13, disrupts this axis, enhancing macrophage‐mediated phagocytosis and suppressing tumor growth without inducing anemia.
Peng‐Cheng Yu, Chen‐Xi Yue, Wen‐Zhong Dong, Cui‐Yun Hao, Yi‐Fan Qiao, Di Liu, Xin Zhang, Qi Zhan, Jia‐Bao Yao, Dong‐Ping Wang, Peng Cao, Ying‐Zhe Fan, Ye Yu   +12 more
wiley   +1 more source

Platelet-derived microparticles adoptively transfer integrin β3 to promote antitumor effect of tumor-infiltrating T cells

OncoImmunology
Approximately two-thirds of hepatocellular carcinoma (HCC) is considered a “cold tumor” characterized by few tumor-infiltrating T cells and an abundance of immunosuppressive cells. Cilengitide, an integrin αvβ3 inhibitor, has failed in clinical trials as
Mimi Zhou, Yali Feng, Xiaoli Zhang, Jianguo Chen, Naijuan Yao, Shan Fu, Tianzhi Ni, Yi Chen, Fei Xie, Sahasrabda Roy, Jinfeng Liu, Yuan Yang, Yingli He, Yingren Zhao, Nan Yang   +14 more
doaj   +1 more source

Synthesis and biological evaluation of RGD and isoDGR peptidomimetic-α-amanitin conjugates for tumor-targeting

Beilstein Journal of Organic Chemistry, 2018
RGD-α-amanitin and isoDGR-α-amanitin conjugates were synthesized by joining integrin ligands to α-amanitin via various linkers and spacers. The conjugates were evaluated for their ability to inhibit biotinylated vitronectin binding to the purified αVβ3 ...
Lizeth Bodero, Paula López Rivas, Barbara Korsak, Torsten Hechler, Andreas Pahl, Christoph Müller, Daniela Arosio, Luca Pignataro, Cesare Gennari, Umberto Piarulli   +9 more
doaj   +1 more source

Cilengitide inhibits metastatic bone colonization in a nude rat model

Oncology Reports, 2011
Integrins αvβ3 and αvβ5 are considered to play an important role in the pathogenesis of breast cancer bone metastases. This study investigates the effects of the αvβ3/αvβ5 integrin-specific inhibitor cilengitide during early metastatic bone colonization.
Maren, Bretschi, Maximilian, Merz, Dorde, Komljenovic, Martin R, Berger, Wolfhard, Semmler, Tobias, Bäuerle   +5 more
openaire   +3 more sources

Loss of Fibronectin Fiber Tension in Glioblastoma is Associated with Microvascular Proliferations and Immune Cell Infiltration

Advanced Science, Volume 12, Issue 45, December 4, 2025.
Researchers discovered that fibronectin fibers lose their tension in specific areas of glioblastoma brain tumors, accumulating in the lumen of proliferating blood vessels and in parenchyma next to infiltrating immune cell clusters. A novel molecular tension probe enables the mapping of fibronectin's fiber tension in glioblastoma for the first time ...
Michele Crestani, Isabel Gerber, Arnaud Mieville, Katrin Frauenknecht, Theoni Maragkou, Tibor Hortobagyi, Viola Vogel   +6 more
wiley   +1 more source

Cilengitide interferes with HUVEC adhesion on low-density β1 integrin substrates.

, 2013
(a) HUVEC short-term adhesion assays performed on vitronectin (αVβ3 ligand), fibronectin (α5β1>αVβ3 ligand) and collagen I (α1β1/α2β1 ligand) coated at the indicated concentrations, in medium only (black bars) or in the presence of EMD135981 (gray bars ...
Gian Carlo Alghisi (374631), Curzio Rüegg (5520968), Lionel Ponsonnet (374632)   +2 more
core   +1 more source