Results 1 to 10 of about 18,298 (255)

BICD2 promotes ciliogenesis by facilitating CP110 removal from the mother centriole [PDF]

EMBO Reports
Cilia are hair-like organelles that protrude from the cell surface and play vital roles in embryonic development and tissue homeostasis. Removal of centriolar coiled-coil protein 110 (CP110) from the mother centriole is a critical step in ciliogenesis ...
Wenjun Kuang, Hao Jin, Shanshan Xie, Guangshuo Ou, Tianhua Zhou   +4 more
doaj   +2 more sources

Tissue-specific requirement of sodium channel and clathrin linker 1 (Sclt1) for ciliogenesis during limb development [PDF]

Frontiers in Cell and Developmental Biology, 2022
Primary cilia have essential roles as signaling centers during development and adult homeostasis. Disruption of ciliary structure or function causes congenital human disorders called ciliopathies.
Hankyu Lee, Hankyu Lee, Kyeong-Hye Moon, Kyeong-Hye Moon, Jieun Song, Jieun Song, Suyeon Je, Suyeon Je, Jinwoong Bok, Jinwoong Bok, Jinwoong Bok, Hyuk Wan Ko, Hyuk Wan Ko   +12 more
doaj   +2 more sources

Centrosomal JAK2 Tyrosine Kinase Regulates Primary Cilia Length, Cell Proliferation, and Cilia Orientation During Cell Migration. [PDF]

FASEB J
Growth hormone (GH) activates GHR at the primary cilium and stimulates centrosomal JAK2. JAK2 centrosomal localization requires both its SH2 domain and kinase activity. Cells expressing JAK2 variants deficient in centrosomal targeting show impaired control of cilia length, reduced proliferation, and cell migration compared with parental and JAK2 WT ...
Karki G, Boone L, Klaiber T, Lambert T, Kimball B, Burkhart B, Youssef M, Diakonova M.   +7 more
europepmc   +2 more sources

Bi-allelic INTU variants define a ciliopathy disorder characterized by orofacial, digital, and cardiac anomalies [PDF]

HGG Advances
Summary: The primary cilium is a small organelle that plays key roles in cellular signaling. Defects in primary cilia formation, morphology, and function cause a heterogeneous group of developmental syndromes termed ciliopathies. The inturned planar cell
Rebekah Rushforth, Kurt Reynolds, Steven I. Estes, Daniel K. Nolan, Mari Mori, Daniel C. Koboldt, Jesse M. Hunter, Rolf W. Stottmann   +7 more
doaj   +2 more sources

Primary cilia in cancer: structures, functions, mechanisms, and therapeutic implications [PDF]

Cancer Biology & Medicine
Primary cilia, microtubule-based organelles protruding from the surfaces of most eukaryotic cells, have critical roles in maintaining cellular homeostasis, by sensing, transducing, and transmitting diverse extracellular and intracellular signals through ...
Miaomiao Zheng, Jun Zhou, Yijie Wang
doaj   +2 more sources

Use of Small-Molecule Inhibitors of CILK1 and AURKA as Cilia-Promoting Drugs to Decelerate Medulloblastoma Cell Replication [PDF]

Biomedicines
Background/Objective: The primary cilium is the sensory organelle of a cell and a dynamic membrane protrusion during the cell cycle. It originates from the centriole at G0/G1 and undergoes disassembly to release centrioles for spindle formation before a ...
Sean H. Fu, Chelsea Park, Niyathi A. Shah, Ana Limerick, Ethan W. Powers, Cassidy B. Mann, Emily M. Hyun, Ying Zhang, David L. Brautigan, Sijie Hao, Roger Abounader, Zheng Fu   +11 more
doaj   +2 more sources

Enhanced Ciliogenesis of Human Bronchial Epithelial Cells by Simulated Microgravity [PDF]

Life
Spaceflight induces a wide array of effects on the human body, notably including pathological changes mediated by alterations in gravity. Abnormalities in the formation of primary cilia (ciliogenesis) can lead to cell cycle arrest and decreased ...
Seung Hyun Bang, Soyoung Hwang, Seon Young Choi, Hyun Joo Kim, Joo Hyung Kim, Sung Ho Lee, Jin Woo Lee, Kuk Hui Son   +7 more
doaj   +2 more sources

Carnitine Protects against MPP⁺-Induced Neurotoxicity and Inflammation by Promoting Primary Ciliogenesis in SH-SY5Y Cells

Cells, 2022
Primary cilia help to maintain cellular homeostasis by sensing conditions in the extracellular environment, including growth factors, nutrients, and hormones that are involved in various signaling pathways.
Ji-Eun Bae, Joon Bum Kim, Doo Sin Jo, Na Yeon Park, Yong Hwan Kim, Ha Jung Lee, Seong Hyun Kim, So Hyun Kim, Mikyung Son, Pansoo Kim, Hong-Yeoul Ryu, Won Ha Lee, Zae Young Ryoo, Hyun-Shik Lee, Yong-Keun Jung, Dong-Hyung Cho   +15 more
doaj   +1 more source

Ionizing radiation promotes primary ciliogenesis in glioblastoma cells

Fushe yanjiu yu fushe gongyi xuebao, 2021
The aim of this study was to investigate the effects of ionizing radiation (IR) on ciliogenesis of human glioblastoma cells. The glioblastoma cell lines M059K and M059J were exposed to X-ray or carbon ion at different doses, and the incidence and length ...
MA Wei, MA Qinglong, WEI Li, HUA Junrui, HE Jinpeng, WANG Jufang   +5 more
doaj   +1 more source

FOP Negatively Regulates Ciliogenesis and Promotes Cell Cycle Re-entry by Facilitating Primary Cilia Disassembly

Frontiers in Cell and Developmental Biology, 2020
Primary cilia are microtubule-based, antenna-like organelles, which are formed in G0 phase and resorbed as cells re-enter the cell cycle. It has been reported that primary cilia can influence the timing of cell cycle progression.
Huadong Jiang, Shanshan Liu, Man-Hei Cheung, Aftab Amin, Chun Liang, Chun Liang, Chun Liang, Chun Liang   +7 more
doaj   +1 more source