Results 1 to 10 of about 9,541 (228)

EGF receptor kinase suppresses ciliogenesis through activation of USP8 deubiquitinase

Nature Communications, 2018
The trichoplein-Aurora A pathway inhibits ciliogenesis in proliferating cells. Here the authors EGFR-mediated phosphorylation of the deubiquitinating enzyme USP8 leads to its activation, and this suppresses trichoplein degradation, allowing inhibition of
Kousuke Kasahara, Hiromasa Aoki, Harumi Kagiwada   +2 more
exaly   +2 more sources

Secreted metalloproteases ADAMTS9 and ADAMTS20 have a non-canonical role in ciliary vesicle growth during ciliogenesis

Nature Communications, 2019
Ciliogenesis is a complex process requiring hundreds of molecules, although few secreted proteins have been implicated. Here, the authors show that the secreted metalloproteases ADAMTS9 and ADAMTS20 intracellularly regulate ciliogenesis from unique ...
Friedhelm Hildebrandt, Sumeda Nandadasa, Heon Yung Gee   +2 more
exaly   +2 more sources

Wnt3a Stimulation Promotes Primary Ciliogenesis through β-Catenin Phosphorylation-Induced Reorganization of Centriolar Satellites

Cell Reports, 2020
Summary: Primary cilium is an antenna-like microtubule-based cellular sensing structure. Abnormal regulation of the dynamic assembly and disassembly cycle of primary cilia is closely related to ciliopathy and cancer.
Hee Gu Lee, Jeong-ah Hwang, Yong Tae Kwon   +2 more
exaly   +2 more sources

Carnitine Protects against MPP⁺-Induced Neurotoxicity and Inflammation by Promoting Primary Ciliogenesis in SH-SY5Y Cells

Cells, 2022
Primary cilia help to maintain cellular homeostasis by sensing conditions in the extracellular environment, including growth factors, nutrients, and hormones that are involved in various signaling pathways.
Ji-Eun Bae, Joon Bum Kim, Doo Sin Jo, Na Yeon Park, Yong Hwan Kim, Ha Jung Lee, Seong Hyun Kim, So Hyun Kim, Mikyung Son, Pansoo Kim, Hong-Yeoul Ryu, Won Ha Lee, Zae Young Ryoo, Hyun-Shik Lee, Yong-Keun Jung, Dong-Hyung Cho   +15 more
doaj   +1 more source

Ubiquitin-proteasome system controls ciliogenesis at the initial step of axoneme extension [PDF]

Nature Communications, 2014
Kousuke Kasahara, Tohru Kiyono
exaly   +2 more sources

Ionizing radiation promotes primary ciliogenesis in glioblastoma cells

Fushe yanjiu yu fushe gongyi xuebao, 2021
The aim of this study was to investigate the effects of ionizing radiation (IR) on ciliogenesis of human glioblastoma cells. The glioblastoma cell lines M059K and M059J were exposed to X-ray or carbon ion at different doses, and the incidence and length ...
MA Wei, MA Qinglong, WEI Li, HUA Junrui, HE Jinpeng, WANG Jufang   +5 more
doaj   +1 more source

The MST1/2-SAV1 complex of the Hippo pathway promotes ciliogenesis [PDF]

Nature Communications, 2014
Cheol-hee Kim, Dae-sik Lim, Junhong Leng
exaly   +2 more sources

CCP5 and CCP6 retain CP110 and negatively regulate ciliogenesis

BMC Biology, 2023
Background The axonemal microtubules of primary cilium undergo a conserved protein posttranslational modification (PTM) — polyglutamylation. This reversible procedure is processed by tubulin tyrosine ligase-like polyglutamylases to form secondary ...
Yujuan Wang, Yuan Zhang, Xinyu Guo, Yiqiang Zheng, Xinjie Zhang, Shanshan Feng, Hui-Yuan Wu   +6 more
doaj   +1 more source

FOP Negatively Regulates Ciliogenesis and Promotes Cell Cycle Re-entry by Facilitating Primary Cilia Disassembly

Frontiers in Cell and Developmental Biology, 2020
Primary cilia are microtubule-based, antenna-like organelles, which are formed in G0 phase and resorbed as cells re-enter the cell cycle. It has been reported that primary cilia can influence the timing of cell cycle progression.
Huadong Jiang, Shanshan Liu, Man-Hei Cheung, Aftab Amin, Chun Liang, Chun Liang, Chun Liang, Chun Liang   +7 more
doaj   +1 more source

Centriolar satellites expedite mother centriole remodeling to promote ciliogenesis

eLife, 2023
Centrosomes are orbited by centriolar satellites, dynamic multiprotein assemblies nucleated by Pericentriolar material 1 (PCM1). To study the requirement for centriolar satellites, we generated mice lacking PCM1, a crucial component of satellites. Pcm1−/−
Emma A Hall, Dhivya Kumar, Suzanna L Prosser, Patricia L Yeyati, Vicente Herranz-Pérez, Jose Manuel García-Verdugo, Lorraine Rose, Lisa McKie, Daniel O Dodd, Peter A Tennant, Roly Megaw, Laura C Murphy, Marisa F Ferreira, Graeme Grimes, Lucy Williams, Tooba Quidwai, Laurence Pelletier, Jeremy F Reiter, Pleasantine Mill   +18 more
doaj   +1 more source