Results 91 to 100 of about 19,567 (308)

Interleukin-1β sequesters hypoxia inducible factor 2α to the primary cilium. [PDF]

, 2013
BACKGROUND: The primary cilium coordinates signalling in development, health and disease. Previously we have shown that the cilium is essential for the anabolic response to loading and the inflammatory response to interleukin-1β (IL-1β).
AC Lin, AK Wann, AK Wann, AM Malone, AR Sartori-Cintra, BL Thoms, BL Thoms, CA Clement, CA Clement, CF Chang, CJ Haycraft, CJ Haycraft, CR Thoma, D Kong, D Zhu, DA Hoey, DM Katschinski, E Verghese, EN Pugacheva, F Oeffner, GJ Pazour, HA Praetorius, J Kim, JB Catterall, JC Kim, JE Bohonowych, JE Lafont, JF Reiter, JH Moyer, JH Ryu, JM Gerdes, JR Marszalek, JT Eggenschwiler, KC Corbit, KC Corbit, L Schneider, M Windheim, MA Lancaster, MF Bijlsma, NV Prodromou, P Jaakkola, PD Taulman, PV Tran, R Rohatgi, RD Thornton, S Abdul-Majeed, S Kim, S Massinen, S Murakami, S Proulx-Bonneau, S Yang, SH Low, SM Nauli, SN Greer, SR McGlashan, SR McGlashan, T Caspary, TY Besschetnova, X Xue, Y Li, YJ Jung   +60 more
core   +1 more source

The Heterotaxy Gene CCDC11 Is Important for Cytokinesis via RhoA Regulation

Cytoskeleton, EarlyView.
ABSTRACT Mutations in CCDC11 (cfap53) have been identified in multiple patients with heterotaxy (Htx), a disorder of left–right (LR) patterning of the internal organs. In Xenopus, depletion of Ccdc11 causes defects in LR patterning, recapitulating the patient phenotype. Upon Ccdc11 depletion, monociliated cells of the Left–Right Organizer (LRO) exhibit
Saurabh S. Kulkarni, Rachel E. Stephenson, Sarah Amalraj, Angelo Arrigo, Ewelina Betleja, James J. Moresco, John R. Yates III, Moe R. Mahjoub, Ann L. Miller, Mustafa K. Khokha   +9 more
wiley   +1 more source

Rare coding SNP in DZIP1 gene associated with late-onset sporadic Parkinson's disease [PDF]

, 2011
We present the first application of the hypothesis-rich mathematical theory to genome-wide association data. The Hamza et al. late-onset sporadic Parkinson's disease genome-wide association study dataset was analyzed.
A Lerner, A Ruepp, AA Merchant, AM Glazer, B Bakir-Gungor, B Dass, C Wolff, CB Do, CH Hawkes, D Subramaniam, DAD Monte, DI Chasman, E Eskin, FL Moore, H-C Fung, HR Kim, J Simón-Sánchez, K Lai, K Roeder, K Roeder, K Roeder, K Sekimizu, K Tsuboi, L Lum, LA Hindorff, LM Bekris, M Bak, M Plaisant, M Saad, M-X Li, N Miao, O Bragina, P Mill, P Whitton, PA Beachy, PW Ingham, RE Lamont, S Purcell, SM Chambers, SY Tay, TA Manolio, TH Hamza, TL Edwards, TS Keshava Prasad, V Palma, VF Rafuse, W Satake, Y Katoh   +47 more
core   +3 more sources

MAPK15 Controls Hedgehog Signaling in Medulloblastoma Cells by Regulating Primary Ciliogenesis

Cancers, 2021
Simple Summary In eukaryotes, MAPK15 controls the assembly of primary cilia, which are microtubule-based cell surface organelles necessary for sensing and processing developmental signals as well as for transducing tumorigenic Hedgehog signaling in ...
Silvia Pietrobono, Lorenzo Franci, F. Imperatore, C. Zanini, B. Stecca, M. Chiariello   +5 more
semanticscholar   +1 more source

Phosphorylation at the Helm: Kinase‐Mediated Regulation of Primary Cilia Assembly and Disassembly

Cytoskeleton, EarlyView.
ABSTRACT The primary cilium serves as an antenna of most vertebrate cells and is important for conveying cues from several signaling pathways into appropriate cellular responses during development and homeostasis. Cilia assembly and disassembly processes are thought to be strictly controlled; however, the precise nature of molecular events underlying ...
Andrea Lacigová, Lukáš Čajánek
wiley   +1 more source

Kinesin-2 family in vertebrate ciliogenesis [PDF]

Proceedings of the National Academy of Sciences, 2012
The differentiation of cilia is mediated by kinesin-driven transport. As the function of kinesins in vertebrate ciliogenesis is poorly characterized, we decided to determine the role of kinesin-2 family motors—heterotrimeric kinesin-II and the homodimeric Kif17 kinesin—in zebrafish cilia.
Katarzyna Brodowska, Yoshihiro Omori, Peter Kovach, Jarema Malicki, Chengtian Zhao   +4 more
openaire   +3 more sources

Shortened primary cilium length and dysregulated Sonic hedgehog signaling in Niemann-Pick C1 disease [PDF]

, 2017
The Niemann-Pick type C1 (NPC1) disease is a neurodegenerative lysosomal storage disorder due to mutations in the NPC1 gene, encoding a transmembrane protein related to the Sonic hedgehog receptor, Patched, and involved in intracellular trafficking of ...
Canterini, Sonia, Dardis, Andrea, DE STEFANO, Maria Egle, Dragotto, Jessica, Erickson, Robert P., Fiorenza, Maria Teresa, Mangia, Franco, Zampieri, Stefania   +7 more
core   +1 more source

PLK4: Master Regulator of Centriole Duplication and Its Therapeutic Potential

Cytoskeleton, EarlyView.
ABSTRACT Centrosomes catalyze the assembly of a microtubule‐based bipolar spindle, essential for the precise chromosome segregation during cell division. At the center of this process lies Polo‐Like Kinase 4 (PLK4), the master regulator that controls the duplication of the centriolar core to ensure the correct balance of two centrosomes per dividing ...
Muhammad Hamzah, Franz Meitinger, Midori Ohta   +2 more
wiley   +1 more source

MLN4924: additional activities beyond neddylation inhibition

Molecular & Cellular Oncology, 2019
MLN4924, a small molecular inhibitor of NEDD8 (neuronal precursor cell-expressed developmentally downregulated protein 8) activating enzyme (NAE), blocks cullin neddylation to inactivate cullin-RING ligase. We found that MLN4924 has additional activities:
Qiyin Zhou, Yi Sun
doaj   +1 more source

Interplay of RFX transcription factors 1, 2 and 3 in motile ciliogenesis

Nucleic Acids Research, 2020
Cilia assembly is under strict transcriptional control during animal development. In vertebrates, a hierarchy of transcription factors (TFs) are involved in controlling the specification, differentiation and function of multiciliated epithelia.
S. Lemeille, M. Paschaki, D. Baas, L. Morlé, Jean-Luc Duteyrat, Aouatef Ait-Lounis, E. Barras, F. Soulavie, J. Jerber, Joëlle Thomas, Yong Zhang, Michael J. Holtzman, W. S. Kistler, W. Reith, B. Durand   +14 more
semanticscholar   +1 more source