Results 101 to 110 of about 19,567 (308)
Dynamics of primary cilia in endothelial and mesenchymal cells throughout mouse lung development
Developmental Dynamics, EarlyView.Abstract Cilia are specialized structures found on a variety of mammalian cells, with variable roles in the transduction of mechanical and biological signals (by primary cilia, PC), as well as in the generation of fluid flow (by motile cilia). Their critical role in the establishment of a left–right axis in early development is well described, as well ...
Stephen Spurgin +8 more
wiley +1 more source
Rolling ES cells down the Waddington landscape with Oct4 and Sox2
, 2011 Embryonic stem cell (ESC) pluripotency is maintained by core transcriptional circuits whereby critical factors sustain their own expression while preventing the expression of genes required for differentiation. Thomson et al.
Cavalli, G., Iovino, N.
core +1 more source
Developmental Dynamics, EarlyView.Abstract Background Mouse nodal immotile cilia mechanically sense the bending direction for left–right (L–R) determination and activate the left‐side‐specific signaling cascade, leading to increased Nodal activity. Asymmetric distribution of Pkd2, a crucial channel for L–R determination, on immotile cilia has been reported recently. However, the causal
Takanobu A. Katoh +5 more
wiley +1 more source
Coordination of Rab8 and Rab11 in primary ciliogenesis [PDF]
Proceedings of the National Academy of Sciences, 2010 Primary cilia are microtubule-based membrane projections located at the surface of many cells. Defects in primary cilia formation have been implicated in a number of genetic disorders, such as Bardet-Biedl Syndrome and Polycystic Kidney Disease.
Amlan Das +6 more
openaire +3 more sources
ViewThe lack of a cure for osteoarthritis (OA), a prevalent joint disease among older individuals, remains an ongoing challenge. Obesity is a common risk factor for OA. Chondrocyte autophagy plays a crucial role in delaying the onset of OA.
Xiaodong Li +7 more
doaj +1 more source
A role for Gle1, a regulator of DEAD-box RNA helicases, at centrosomes and basal bodies. [PDF]
, 2017 Control of organellar assembly and function is critical to eukaryotic homeostasis and survival. Gle1 is a highly conserved regulator of RNA-dependent DEAD-box ATPase proteins, with critical roles in both mRNA export and translation.
Akef, Abdalla +2 more
core +1 more source
SCFFbxw5 targets kinesin‐13 proteins to facilitate ciliogenesis
EMBO Journal, 2021 Microtubule depolymerases of the kinesin‐13 family play important roles in various cellular processes and are frequently overexpressed in different cancer types.
Jörg Schweiggert +8 more
semanticscholar +1 more source
Coordination of IFT20 With Other IFT Components Is Required for Ciliogenesis
Journal of Clinical Laboratory Analysis, EarlyView.Intraflagellar transport is a bidirectional transport system essential for ciliogenesis. Using the IFT20 knockout cell lines established in this study, we found that IFT20 deficiency significantly impaired ciliogenesis and reduced cilium length. Further investigation revealed that IFT20 interacted with other IFT proteins and regulated their levels and ...
Weishu Wang +6 more
wiley +1 more source
Primary cilia contribute to the aggressiveness of atypical teratoid/rhabdoid tumors
Cell Death and Disease, 2022 Atypical teratoid/rhabdoid tumor (AT/RT) is a highly malignant brain tumor in infants that is characterized by loss of nuclear expression of SMARCB1 or SMARCA4 proteins. Recent studies show that AT/RTs comprise three molecular subgroups, namely AT/RT-TYR,
Lena Blümel +28 more
doaj +1 more source
Functional Characterization of Cfap206 for Bivalve Ciliogenesis by RNAi and CRISPR/Cas9 Technologies
Frontiers in Marine Science, 2022 Cilia are organelles located on the surface of eukaryotic cells and play important roles in numerous physiological and developmental processes. Cilia- and flagella-associated proteins (CFAP family) are well known due to their close relation to the ...
Yinghui Wang +13 more
doaj +1 more source