Results 101 to 110 of about 21,394 (289)
LUBAC regulates ciliogenesis by promoting CP110 removal from the mother centriole
Journal of Cell Biology, 2021 Shen et al. identify the linear ubiquitin ligase complex LUBAC as a novel regulator of ciliogenesis and further mechanistically explain that LUBAC regulates ciliogenesis by promoting the removal of CP110 on the mother centriole.
Xiao-Lin Shen +22 more
semanticscholar +1 more source
Club Cells in Nasal Epithelial Repair: Insights From an IL‐13‐Induced Inflammatory Model
Allergy, EarlyView.Four inflammatory endotypes of CRSwNP, defined by eosinophil and neutrophil infiltration, show distinct patterns of basal, club, ciliated, and goblet cell expression in nasal epithelium. Using an ALI‐HNECs model, we demonstrate that IL‐13 impairs mucociliary function by promoting club‐to‐goblet cell differentiation while inhibiting club‐to‐ciliated ...
Zhi‐Qun Huang +13 more
wiley +1 more source
Mechanisms of ciliogenesis suppression in dividing cells [PDF]
Cellular and Molecular Life Sciences, 2016 The primary cilium is a non-motile and microtubule-enriched protrusion ensheathed by plasma membrane. Primary cilia function as mechano/chemosensors and signaling hubs and their disorders predispose to a wide spectrum of human diseases. Most types of cells assemble their primary cilia in response to cellular quiescence, whereas they start to retract ...
Goto, Hidemasa +2 more
openaire +2 more sources
GJA1 depletion causes ciliary defects by affecting Rab11 trafficking to the ciliary base
eLife, 2022 The gap junction complex functions as a transport channel across the membrane. Among gap junction subunits, gap junction protein α1 (GJA1) is the most commonly expressed subunit.
Dong Gil Jang +8 more
doaj +1 more source
Development and disease of the photoreceptor cilium [PDF]
, 2009 Primary cilia are microtubule-rich hair-like extensions protruding from the surface of most post-mitotic cells. They act as sensory organelles that help interpret various environmental cues.
Adams +48 more
core +1 more source
International Journal of Molecular Sciences, 2021 Bardet-Biedl syndrome (BBS) is a ciliopathy characterized by retinal dystrophy, renal cysts, obesity and polydactyly. BBS genes have been implicated in ciliogenesis, hedgehog signaling and retinal pigment epithelium maturation.
C. A. B. Hey +6 more
semanticscholar +1 more source
Microtubule Inner Protein CFAP77 Contributes to Sperm Motility and Male Fertility in Mice
Andrology, EarlyView.ABSTRACT Background Sperm motility is essential for male fertility, and its regulation is dependent on the structural integrity of the axoneme. The axoneme consists of a conserved “9+2” microtubule arrangement and is supported by microtubule inner proteins. However, the functional significance of many microtubule inner proteins remains unclear.
Haoting Wang +4 more
wiley +1 more source
NRF2 and Primary Cilia: An Emerging Partnership
Antioxidants, 2020 When not dividing, many cell types target their centrosome to the plasma membrane, where it nucleates assembly of a primary cilium, an antenna-like signaling structure consisting of nine concentric microtubule pairs surrounded by membrane.
Ana Martin-Hurtado +3 more
doaj +1 more source
A role for Tctex-1 (DYNLT1) in controlling primary cilium length [PDF]
, 2011 The microtubule motor complex cytoplasmic dynein is known to be involved in multiple processes including endomembrane organization and trafficking, mitosis, and microtubule organization.
MacCarthy-Morrogh, LJ +3 more
core +2 more sources
Brain Pathology, EarlyView.circRMST (hsa_circ_0099634) is by far the most abundant isoform from the RMST locus. It is highly expressed in cancer cells throughout ependymoma patient samples and is located in the cytoplasm. circRMST knockdown causes cell cycle arrest and induces differentiation, and it is a marker for poor prognosis. The figure is made using BioRender.
Ulvi Ahmadov +6 more
wiley +1 more source