Results 111 to 120 of about 21,394 (289)

Oleic and linoleic acids induce oxidative stress in chondrocytes by inhibiting autophagy‐regulated ciliogenesis

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The lack of a cure for osteoarthritis (OA), a prevalent joint disease among older individuals, remains an ongoing challenge. Obesity is a common risk factor for OA. Chondrocyte autophagy plays a crucial role in delaying the onset of OA.
Xiaodong Li, Chuanyuan Mao, Guantong Sun, Chen Zhao, Jingjing Dai, Fei Yang, Lei Wang, Xiaoqing Wang   +7 more
doaj   +1 more source

The role of primary cerebrovascular cilia as novel sensory and signaling hubs for AD/ADRD risk factors [PDF]

Alzheimers Dement
Abstract Background Primary cilia are microtubule‐based organelles, extending from the surface of vascular endothelial cells to sense extracellular signaling cues and fluid‐shear stress. Cilia dysfunctions (ciliopathies) manifest a broad range of symptoms, including vascular dysfunction, hypertension (HTN) and cognitive and memory dysfunction.
Sunderman C, Aboualaiwi W, Forero K, Gallagher G, Azizi N.   +4 more
europepmc   +2 more sources

A Smo/Gli multitarget hedgehog pathway inhibitor impairs tumor growth [PDF]

, 2019
Pharmacological Hedgehog (Hh) pathway inhibition has emerged as a valuable anticancer strategy. A number of small molecules able to block the pathway at the upstream receptor Smoothened (Smo) or the downstream effector glioma-associated oncogene 1 (Gli1)
Balducci, Silvia, BASILI, IRENE, Botta, Bruno, Bufalieri, Francesca, Caimano, Miriam, Di Marcotullio, Lucia, Ghirga, Francesca, Infante, Paola, LORICCHIO, ELENA, LOSPINOSO SEVERINI, LUDOVICA, Maroder, Marella, Moretti, Marta, Mori, Mattia, Quaglio, Deborah, ROMEO, ISABELLA   +14 more
core   +1 more source

Primary Ciliogenesis by 2-Isopropylmalic Acid Prevents PM2.5-Induced Inflammatory Response and MMP-1 Activation in Human Dermal Fibroblasts and a 3-D-Skin Model

International Journal of Molecular Sciences, 2021
Particulate matters (PMs) increase oxidative stress and inflammatory response in different tissues. PMs disrupt the formation of primary cilia in various skin cells, including keratinocytes and melanocytes.
J. Bae, D. Min, J. Choi, Hyunjung Choi, Joon Bum Kim, N. Park, Doo Sin Jo, Yong Hwan Kim, Hye-won Na, Yoon Jae Kim, Eun Sung Kim, Hyoung-june Kim, D. Cho   +12 more
semanticscholar   +1 more source

PLK4 is a potential therapeutic target in nonmelanoma skin cancers: Evidence from molecular and in vivo studies

Photochemistry and Photobiology, EarlyView.
Exposure to solar ultraviolet radiation is the main etiologic driver of nonmelanoma skin cancers (NMSCs), including basal cell (BCC) and cutaneous squamous cell carcinomas (cSCC), which are the most prevalent types of cancers in the US. In this study, we demonstrate that the serine/threonine kinase Polo‐like kinase 4 (PLK4) is overexpressed in NMSCs ...
Mary A. Ndiaye, Debra R. Garvey, Gagan Chhabra, Chandra K. Singh, Minakshi Nihal, Nihal Ahmad   +5 more
wiley   +1 more source

The exocyst in ciliogenesis

Renal Failure
The primary cilium is an organelle found on different cell types in many organs, and is important for human health including the kidney. Diseases due to abnormal or absent cilia are termed ciliopathies and ADPKD is one of the most common ciliopathies and the fourth leading cause of ESKD.
Brennan Winkler, Kasey Lerner, Joshua H. Lipschutz   +2 more
openaire   +2 more sources

The Role of Primary Cilia in Thyroid Cancer: From Basic Research to Clinical Applications

Frontiers in Endocrinology, 2021
Primary cilia (PC) are microtubule-based organelles that are present on nearly all thyroid follicle cells and play an important role in physiological development and in maintaining the dynamic homeostasis of thyroid follicles.
Cheng-Xu Ma, Cheng-Xu Ma, Xiao-Ni Ma, Xiao-Ni Ma, Ying-Dong Li, Song-Bo Fu, Song-Bo Fu   +6 more
doaj   +1 more source

Wdpcp, a PCP Protein Required for Ciliogenesis, Regulates Directional Cell Migration and Cell Polarity by Direct Modulation of the Actin Cytoskeleton [PDF]

, 2013
Planar cell polarity (PCP) regulates cell alignment required for collective cell movement during embryonic development. This requires PCP/PCP effector proteins, some of which also play essential roles in ciliogenesis, highlighting the long-standing ...
Adam V. Kwiatkowski, AJ Ross, B Schermer, Bishwanath Chatterjee, C Cui, C Jones, C Jones, C Stuckenholz, CB Kimmel, CD Nobes, Cecilia W. Lo, Chandrakala Puligilla, Cheng Cui, CJ Haycraft, CU Stirnimann, CW Sipe, D Huangfu, D Huangfu, D Yelon, Deanne Francis, E Joo, EK Vladar, Elias T. Spiliotis, F Hildebrandt, GJ Pazour, Gregory J. Pazour, Hisato Yagi, HM Phillips, HM Phillips, I Drummond, J Magdalena, J Wang, J Wang, JB Wallingford, JB Wallingford, JL Badano, Jovenal T. San Agustin, K Schmidt, K Takemaru, KC Corbit, KC Corbit, Lisa M. Swanhart, M Castori, M Fliegauf, M Kelly, M Kinoshita, M Montcouquiol, M Simons, Matthew P. Scott, Matthew W. Kelley, Neil A. Hukriede, Q Hu, Q Yu, Qing Yu, R Rohatgi, RA Meseroll, Richard J. Francis, RJ Francis, Rocky Tuan, S Collier, S Maretto, S Saburi, SD Weatherbee, SK Kim, Subramaniam Sanker, T Caspary, T Kudoh, Tania Chatterjee, Terry Tansey, Thomas P. Lozito, TJ Park, X Wen, Xiaoqin Liu, Y Wang, Zhen Zhang   +74 more
core   +4 more sources

The Role of Centrosome Distal Appendage Proteins (DAPs) in Nephronophthisis and Ciliogenesis

International Journal of Molecular Sciences, 2021
The primary cilium is found in most mammalian cells and plays a functional role in tissue homeostasis and organ development by modulating key signaling pathways.
F. Mansour, F. Boivin, I. Shaheed, M. Schueler, K. Schmidt-Ott   +4 more
semanticscholar   +1 more source

Mitochondrial control of ciliary gene expression and structure in striatal neurons

The Journal of Physiology, EarlyView.
Abstract figure legend Neurons drive animal behaviour by receiving and transmitting information and require energy, primarily supplied by mitochondria, to function. Additionally, neurons need to sense environmental changes to adapt, a function that is locally played by the primary cilia.
Dogukan H. Ulgen, Alessandro Chioino, Olivia Zanoletti, Albert Quintana, Elisenda Sanz, Carmen Sandi   +5 more
wiley   +1 more source