Results 11 to 20 of about 9,541 (228)

TRIP6 functions in brain ciliogenesis [PDF]

Nature Communications, 2021
AbstractTRIP6, a member of the ZYXIN-family of LIM domain proteins, is a focal adhesion component.Trip6deletion in the mouse, reported here, reveals a function in the brain: ependymal and choroid plexus epithelial cells are carrying, unexpectedly, fewer and shorter cilia, are poorly differentiated, and the mice develop hydrocephalus.
Lucien Frappart, Lucien Frappart, Paulius Grigaravicius, Aspasia Ploubidou, Peter A Herrlich, Shalmali Shukla, Ronny Haenold, Sigrun Nagel, Shamci Monajembashi, Zhao-Qi Wang, Wookee Min, Pavel Urbanek, Heike Heuer, Alicia Tapias, Olivier Kassel   +14 more
openaire   +7 more sources

A meckelin–filamin A interaction mediates ciliogenesis [PDF]

Human Molecular Genetics, 2011
MKS3, encoding the transmembrane receptor meckelin, is mutated in Meckel-Gruber syndrome (MKS), an autosomal-recessive ciliopathy. Meckelin localizes to the primary cilium, basal body and elsewhere within the cell. Here, we found that the cytoplasmic domain of meckelin directly interacts with the actin-binding protein filamin A, potentially at the ...
Matthew Adams, Roslyn Simms, Zakia Abdelhamed, Helen R. Dawe, Katarzyna Szymańska, Clare V. Logan, Gabrielle Wheway, Eva Pitt, Keith Gull, Margaret A. Knowles, Edward Blair, Sally H. Cross, John A. Sayer, Colin A. Johnson   +13 more
openalex   +6 more sources

Roles for ELMOD2 and Rootletin in ciliogenesis [PDF]

Molecular Biology of the Cell, 2021
The ARF GAP ELMOD2, Rootletin, and ARL2 all act in a common pathway to suppress spurious ciliation upstream of CP110 and to maintain centrosome cohesion.
Tamara Caspary, Uwe Wolfrum, Richard A. Kahn, Joshua Linnert, Eduardo D. Gigante, Rachel E. Turn   +5 more
openaire   +4 more sources

Autophagy and Ciliogenesis

JMA Journal, 2021
Autophagy is a major intracellular degradation system and plays important roles in various physiological processes such as metabolic adaptation and intracellular homeostasis. It degrades intracellular components both randomly and selectively. Autophagic activity is tightly regulated primarily by nutrient availability, but also by other extracellular ...
Yasuhiro Yamamoto, Noboru Mizushima
openaire   +3 more sources

Mechanobiology of Ciliogenesis [PDF]

BioScience, 2014
Cilia are force-generating and -sensing organelles that serve as mechanical interfaces between the cell and the extracellular environment. Cilia are present in tissues that adaptively respond to mechanical loading and fluid flow, and defects in ciliary function can lead to diseases affecting these tissues.
Ishikawa, Hiroaki, Marshall, Wallace F
openaire   +5 more sources

Ciliogenesis: Polarity Proteins on the Move [PDF]

Current Biology, 2004
The formation and maintenance of cilia and flagella require a selective and directed transport along the axoneme, a characteristic central bundle of microtubules. Recent evidence suggests an interesting link between the generation of cilia and the protein complexes that establish apico-basal cell polarity.
André Bachmann, Olaf Bossinger
openaire   +3 more sources

Nonredundant roles of DIAPHs in primary ciliogenesis [PDF]

Journal of Biological Chemistry, 2021
Primary cilia are hubs for several signaling pathways, and disruption in cilia function and formation leads to a range of diseases collectively known as ciliopathies. Both ciliogenesis and cilia maintenance depend on vesicle trafficking along a network of microtubules and actin filaments toward the basal body.
Oliva Palander, Adam Lam, Richard F. Collins, Theo J. Moraes, William S. Trimble   +4 more
openaire   +2 more sources

CEP162: A critical regulator of ciliary transition zone assembly and its implications in ciliopathies. [PDF]

J Cell Commun Signal
Abstract CEP162, a 162‐kDa centrosome protein, is a crucial centrosomal adapter, mediating cell differentiation and polarization. CEP162 maintains mitosis by dynamically stabilizing microtubules. CEP162 promotes the transition zone (TZ) assembly in the basal body through interaction with CEP131, CEP290, and axoneme microtubules as well as the distal ...
Yin J, Bai J, He X, He W, Miao H, Zhang M, Yu Z, Ni B.   +7 more
europepmc   +2 more sources

Enhanced primary ciliogenesis via mitochondrial oxidative stress activates AKT to prevent neurotoxicity in HSPA9/mortalin-depleted SH-SY5Y cells

Molecular Brain, 2023
The primary cilium, an antenna-like structure on the cell surface, acts as a mechanical and chemical sensory organelle. Primary cilia play critical roles in sensing the extracellular environment to coordinate various developmental and homeostatic ...
Ji-Eun Bae, Soyoung Jang, Joon Bum Kim, Hyejin Hyung, Na Yeon Park, Yong Hwan Kim, So Hyun Kim, Seong Hyun Kim, Jin Min Ha, Gyeong Seok Oh, Kyuhee Park, Kwiwan Jeong, Jae Seon Jang, Doo Sin Jo, Pansoo Kim, Hyun-Shik Lee, Zae Young Ryoo, Dong-Hyung Cho   +17 more
doaj   +1 more source

Arl13b and the exocyst interact synergistically in ciliogenesis [PDF]

Molecular Biology of the Cell, 2016
Arl13b belongs to the ADP-ribosylation factor family within the Ras superfamily of regulatory GTPases. Mutations in Arl13b cause Joubert syndrome, which is characterized by congenital cerebellar ataxia, hypotonia, oculomotor apraxia, and mental retardation.
Tamara Caspary, Alexandre Benmerah, Alexandre Benmerah, Michael P. East, Ben Fogelgren, Richard A. Kahn, Hugo Moreiras, Joshua H. Lipschutz, Joshua H. Lipschutz, Rania Ghossoub, Soo Young Choi, Nicole L. Umberger, Xiaofeng Zuo, Duarte C. Barral, Cecília Seixas, Noemi Polgar   +15 more
openaire   +2 more sources