Results 11 to 20 of about 19,567 (308)
JMA Journal, 2021 Autophagy is a major intracellular degradation system and plays important roles in various physiological processes such as metabolic adaptation and intracellular homeostasis. It degrades intracellular components both randomly and selectively.
Yasuhiro Yamamoto, N. Mizushima
semanticscholar +4 more sources
Structure of the ciliogenesis-associated CPLANE complex
Science Advances, 2022 Dysfunctional cilia cause pleiotropic human diseases termed ciliopathies. These hereditary maladies are often caused by defects in cilia assembly, a complex event that is regulated by the ciliogenesis and planar polarity effector (CPLANE) proteins Wdpcp,
Gerasimos Langousis +5 more
semanticscholar +4 more sources
Roles of the actin cytoskeleton in ciliogenesis.
Journal of Cell Science, 2022 Primary cilia play a key role in the ability of cells to respond to extracellular stimuli, such as signaling molecules and environmental cues. These sensory organelles are crucial to the development of many organ systems, and defects in primary ...
Huxley K. Hoffman, Rytis Prekeris
semanticscholar +3 more sources
TRIP6 functions in brain ciliogenesis [PDF]
Nature Communications, 2021 TRIP6, a member of the ZYXIN-family of LIM domain proteins, is a focal adhesion component. Trip6 deletion in the mouse, reported here, reveals a function in the brain: ependymal and choroid plexus epithelial cells are carrying, unexpectedly, fewer and ...
Shalmali Shukla +13 more
semanticscholar +7 more sources
EGF receptor kinase suppresses ciliogenesis through activation of USP8 deubiquitinase
Nature Communications, 2018 The trichoplein-Aurora A pathway inhibits ciliogenesis in proliferating cells. Here the authors EGFR-mediated phosphorylation of the deubiquitinating enzyme USP8 leads to its activation, and this suppresses trichoplein degradation, allowing inhibition of
Kousuke Kasahara +2 more
exaly +2 more sources
Cell Reports, 2020 Summary: Primary cilium is an antenna-like microtubule-based cellular sensing structure. Abnormal regulation of the dynamic assembly and disassembly cycle of primary cilia is closely related to ciliopathy and cancer.
Hee Gu Lee +2 more
exaly +2 more sources
Mother Centriole Distal Appendages Mediate Centrosome Docking at the Immunological Synapse and Reveal Mechanistic Parallels with Ciliogenesis. [PDF]
, 2015 Cytotoxic T lymphocytes (CTLs) are highly effective serial killers capable of destroying virally infected and cancerous targets by polarized release from secretory lysosomes.
Angus, Karen L +5 more
core +5 more sources
A meckelin–filamin A interaction mediates ciliogenesis [PDF]
Human Molecular Genetics, 2011 MKS3, encoding the transmembrane receptor meckelin, is mutated in Meckel-Gruber syndrome (MKS), an autosomal-recessive ciliopathy. Meckelin localizes to the primary cilium, basal body and elsewhere within the cell. Here, we found that the cytoplasmic domain of meckelin directly interacts with the actin-binding protein filamin A, potentially at the ...
Matthew Adams +13 more
openalex +6 more sources
Ciliogenesis membrane dynamics and organization.
Seminars in Cell & Developmental Biology, 2022 Ciliogenesis is a complex multistep process used to describe assembly of cilia and flagella. These organelles play essential roles in motility and signaling on the surface of cells. Cilia are built at the distal ends of centrioles through the formation of an axoneme that is surrounded by the ciliary membrane.
Huijie Zhao +2 more
semanticscholar +3 more sources
Roles for ELMOD2 and Rootletin in ciliogenesis [PDF]
Molecular Biology of the Cell, 2021 The ARF GAP ELMOD2, Rootletin, and ARL2 all act in a common pathway to suppress spurious ciliation upstream of CP110 and to maintain centrosome cohesion.
Tamara Caspary +5 more
openaire +4 more sources