Structure of the ciliogenesis-associated CPLANE complex
Science Advances, 2022 Dysfunctional cilia cause pleiotropic human diseases termed ciliopathies. These hereditary maladies are often caused by defects in cilia assembly, a complex event that is regulated by the ciliogenesis and planar polarity effector (CPLANE) proteins Wdpcp,
Gerasimos Langousis +5 more
semanticscholar +4 more sources
Ciliogenesis and the DNA damage response: A stressful relationship [PDF]
, 2016 Both inherited and sporadic mutations can give rise to a plethora of human diseases. Through myriad diverse cellular processes, sporadic mutations can arise through a failure to accurately replicate the genetic code or by inaccurate separation of ...
Collis, SJ, Johnson, CA
core +5 more sources
Enhanced Ciliogenesis of Human Bronchial Epithelial Cells by Simulated Microgravity [PDF]
LifeSpaceflight induces a wide array of effects on the human body, notably including pathological changes mediated by alterations in gravity. Abnormalities in the formation of primary cilia (ciliogenesis) can lead to cell cycle arrest and decreased ...
Seung Hyun Bang +7 more
doaj +2 more sources
Bi-allelic INTU variants define a ciliopathy disorder characterized by orofacial, digital, and cardiac anomalies [PDF]
HGG AdvancesSummary: The primary cilium is a small organelle that plays key roles in cellular signaling. Defects in primary cilia formation, morphology, and function cause a heterogeneous group of developmental syndromes termed ciliopathies. The inturned planar cell
Rebekah Rushforth +7 more
doaj +2 more sources
ENKD1 promotes CP110 removal through competing with CEP97 to initiate ciliogenesis [PDF]
EMBO Reports, 2022 Despite the importance of cilia in cell signaling and motility, the molecular mechanisms regulating cilium formation remain incompletely understood. Herein, we characterize enkurin domain‐containing protein 1 (ENKD1) as a novel centrosomal protein that ...
Ting Song +12 more
openalex +2 more sources
The Immune Checkpoint Protein PD-L1 Regulates Ciliogenesis and Hedgehog Signaling [PDF]
CellsThe primary cilium, an antenna-like sensory organelle that protrudes from the surface of most eukaryotic cell types, has become a signaling hub of growing interest given that defects in its structure and/or function are associated with human diseases and
Ewud Agborbesong, Xiaogang Li
doaj +2 more sources
Interplay of RFX transcription factors 1, 2 and 3 in motile ciliogenesis [PDF]
Nucleic Acids Research, 2020 Cilia assembly is under strict transcriptional control during animal development. In vertebrates, a hierarchy of transcription factors (TFs) are involved in controlling the specification, differentiation and function of multiciliated epithelia.
Sylvain Lemeille +14 more
openalex +2 more sources
Rapid Ex-Vivo Ciliogenesis and Dose-Dependent Effect of Notch Inhibition on Ciliogenesis of Respiratory Epithelia [PDF]
Biomolecules, 2020 Background: Cilia are actin based cellular protrusions conserved from algae to complex multicellular organisms like Homo sapiens. Respiratory motile cilia line epithelial cells of the tracheobronchial tree, beat in a synchronous, metachronal wave, moving
Maliha Zahid +5 more
doaj +4 more sources
Bridge-like lipid transfer protein family member 2 suppresses ciliogenesis [PDF]
bioRxiv, 2023 Bridge-like lipid transfer protein family member 2 (BLTP2) is an evolutionary conserved protein with unknown function(s). The absence of BLTP2 in Drosophila melanogaster results in impaired cellular secretion and larval death, while in mice (Mus musculus)
Jan Parolek, Christopher G. Burd
openalex +2 more sources
Centriolar satellites expedite mother centriole remodeling to promote ciliogenesis
bioRxiv, 2022 Centrosomes are orbited by centriolar satellites, dynamic multiprotein assemblies nucleated by PCM1. To study the requirement for centriolar satellites, we generated mice lacking PCM1.
Emma A. Hall +18 more
openalex +2 more sources