CEP162: A critical regulator of ciliary transition zone assembly and its implications in ciliopathies. [PDF]
J Cell Commun SignalAbstract CEP162, a 162‐kDa centrosome protein, is a crucial centrosomal adapter, mediating cell differentiation and polarization. CEP162 maintains mitosis by dynamically stabilizing microtubules. CEP162 promotes the transition zone (TZ) assembly in the basal body through interaction with CEP131, CEP290, and axoneme microtubules as well as the distal ...
Yin J +7 more
europepmc +2 more sources
ALKBH3-dependent m1A demethylation of Aurora A mRNA inhibits ciliogenesis
Cell Discovery, 2022 Primary cilia are antenna-like subcellular structures to act as signaling platforms to regulate many cellular processes and embryonic development. m 1 A RNA modification plays key roles in RNA metabolism and gene expression; however, the physiological ...
Wenjun Kuang +15 more
semanticscholar +1 more source
Ubiquitin-proteasome system controls ciliogenesis at the initial step of axoneme extension [PDF]
Nature Communications, 2014 Kousuke Kasahara, Tohru Kiyono
exaly +2 more sources
Human SFI1 and Centrin form a complex critical for centriole architecture and ciliogenesis
EMBO Journal, 2022 Over the course of evolution, the centrosome function has been conserved in most eukaryotes, but its core architecture has evolved differently in some clades, with the presence of centrioles in humans and a spindle pole body (SPB) in yeast.
Marine. H. Laporte +10 more
semanticscholar +1 more source
Motor Cooperation During Mitosis and Ciliogenesis.
Annual Review of Cell and Developmental Biology, 2022 Cilia and mitotic spindles are microtubule (MT)-based, macromolecular machines that consecutively assemble and disassemble during interphase and M phase of the cell cycle, respectively, and play fundamental roles in how eukaryotic cells swim through a ...
Guangshuo Ou, J. Scholey
semanticscholar +1 more source
Ciliogenesis requires sphingolipid-dependent membrane and axoneme interaction
Proceedings of the National Academy of Sciences of the United States of America, 2022 Significance Using ribosome profiling of cilia regeneration in green algae Chlamydomonas, we uncovered that ciliary genes undergo an early transcriptional activation and late translational suppression, the pattern of which guided us to identify serine ...
Dou Wu +13 more
semanticscholar +1 more source
Mechanobiology of Ciliogenesis [PDF]
BioScience, 2014 Cilia are force-generating and -sensing organelles that serve as mechanical interfaces between the cell and the extracellular environment. Cilia are present in tissues that adaptively respond to mechanical loading and fluid flow, and defects in ciliary function can lead to diseases affecting these tissues.
Ishikawa, Hiroaki, Marshall, Wallace F
openaire +5 more sources
ENKD1 promotes CP110 removal through competing with CEP97 to initiate ciliogenesis
EMBO Reports, 2022 Despite the importance of cilia in cell signaling and motility, the molecular mechanisms regulating cilium formation remain incompletely understood. Herein, we characterize enkurin domain‐containing protein 1 (ENKD1) as a novel centrosomal protein that ...
Ting Song +12 more
semanticscholar +1 more source
Ionizing radiation promotes primary ciliogenesis in glioblastoma cells
Fushe yanjiu yu fushe gongyi xuebao, 2021 The aim of this study was to investigate the effects of ionizing radiation (IR) on ciliogenesis of human glioblastoma cells. The glioblastoma cell lines M059K and M059J were exposed to X-ray or carbon ion at different doses, and the incidence and length ...
MA Wei +5 more
doaj +1 more source
The MST1/2-SAV1 complex of the Hippo pathway promotes ciliogenesis [PDF]
Nature Communications, 2014 Cheol-hee Kim, Dae-sik Lim, Junhong Leng
exaly +2 more sources