Results 31 to 40 of about 21,394 (289)

TRIP6 functions in brain ciliogenesis [PDF]

Nature Communications, 2021
AbstractTRIP6, a member of the ZYXIN-family of LIM domain proteins, is a focal adhesion component.Trip6deletion in the mouse, reported here, reveals a function in the brain: ependymal and choroid plexus epithelial cells are carrying, unexpectedly, fewer and shorter cilia, are poorly differentiated, and the mice develop hydrocephalus.
Shalmali Shukla, Ronny Haenold, Pavel Urbánek, Lucien Frappart, Shamci Monajembashi, Paulius Grigaravicius, Sigrun Nagel, Woo Kee Min, Alicia Tapias, Olivier Kassel, Heike Heuer, Zhao-Qi Wang, Aspasia Ploubidou, Peter Herrlich   +13 more
openaire   +7 more sources

Cep131-Cep162 and Cby-Fam92 complexes cooperatively maintain Cep290 at the basal body and contribute to ciliogenesis initiation

PLoS Biology
Cilia play critical roles in cell signal transduction and organ development. Defects in cilia function result in a variety of genetic disorders. Cep290 is an evolutionarily conserved ciliopathy protein that bridges the ciliary membrane and axoneme at the
Zhimao Wu, Huicheng Chen, Yingying Zhang, Yaru Wang, Lingling Wang, Céline Augière, Yanan Hou, Yuejun Fu, Ying Peng, Bénédicte Durand, Qing Wei   +10 more
openalex   +3 more sources

Localization of PPM1H phosphatase tunes Parkinson’s disease-linked LRRK2 kinase-mediated Rab GTPase phosphorylation and ciliogenesis

bioRxiv, 2023
PPM1H phosphatase reverses Parkinson’s disease-associated, LRRK2-mediated Rab GTPase phosphorylation. We show here that PPM1H relies on an N-terminal amphipathic helix for Golgi localization.
Wondwossen M. Yeshaw, Ayan Adhikari, C. A. Chiang, H. S. Dhekne, Paulina S. Wawro, S. Pfeffer   +5 more
semanticscholar   +1 more source

Rab34 GTPase mediates ciliary membrane formation in the intracellular ciliogenesis pathway [PDF]

Current Biology, 2021
Anil Kumar Ganga, Margaret C. Kennedy, Mai E. Oguchi, Shawn Gray, Kendall E. Oliver, Tracy A. Knight, Enrique M. De La Cruz, Yuta Homma, Mitsunori Fukuda, David K. Breslow   +9 more
openalex   +2 more sources

Mechanobiology of Ciliogenesis [PDF]

BioScience, 2014
Cilia are force-generating and -sensing organelles that serve as mechanical interfaces between the cell and the extracellular environment. Cilia are present in tissues that adaptively respond to mechanical loading and fluid flow, and defects in ciliary function can lead to diseases affecting these tissues.
Ishikawa, Hiroaki, Marshall, Wallace F
openaire   +4 more sources

Ionizing radiation promotes primary ciliogenesis in glioblastoma cells

Fushe yanjiu yu fushe gongyi xuebao, 2021
The aim of this study was to investigate the effects of ionizing radiation (IR) on ciliogenesis of human glioblastoma cells. The glioblastoma cell lines M059K and M059J were exposed to X-ray or carbon ion at different doses, and the incidence and length ...
MA Wei, MA Qinglong, WEI Li, HUA Junrui, HE Jinpeng, WANG Jufang   +5 more
doaj   +1 more source

An actin filament branching surveillance system regulates cell cycle progression, cytokinesis and primary ciliogenesis

Nature Communications, 2023
Dysfunction of cell cycle control and defects of primary ciliogenesis are two features of many cancers. Whether these events are interconnected and the driving mechanism coordinating them remains elusive.
Muqing Cao, Xiaoxiao Zou, Chaoyi Li, Zaisheng Lin, Ni Wang, Z. Zou, Youqiong Ye, J. Seemann, B. Levine, Zaiming Tang, Qing Zhong   +10 more
semanticscholar   +1 more source

Centrobin controls primary ciliogenesis in vertebrates [PDF]

Journal of Cell Biology, 2018
The BRCA2 interactor, centrobin, is a centrosomal protein that has been implicated in centriole duplication and microtubule stability. We used genome editing to ablate CNTROB in hTERT-RPE1 cells and observed an increased frequency of monocentriolar and acentriolar cells.
Yetunde Adesanya Ogungbenro, Teresa Casar Tena, David C. A. Gaboriau, Pierce Lalor, Peter Dockery, Melanie Philipp, Ciaran G. Morrison   +6 more
openalex   +5 more sources

Trisomy 21 induces pericentrosomal crowding delaying primary ciliogenesis and mouse cerebellar development

eLife, 2023
Trisomy 21, the genetic cause of Down syndrome, disrupts primary cilia formation and function, in part through elevated Pericentrin, a centrosome protein encoded on chromosome 21.
Cayla E. Jewett, Bailey L McCurdy, E. O'Toole, Alexander J Stemm-Wolf, Katherine S. Given, Carrie H Lin, Valerie Olsen, Whitney Martin, L. Reinholdt, J. Espinosa, Kelly D. Sullivan, W. Macklin, R. Prekeris, C. Pearson   +13 more
semanticscholar   +1 more source

ALKBH3-dependent m1A demethylation of Aurora A mRNA inhibits ciliogenesis

Cell Discovery, 2022
Primary cilia are antenna-like subcellular structures to act as signaling platforms to regulate many cellular processes and embryonic development. m 1 A RNA modification plays key roles in RNA metabolism and gene expression; however, the physiological ...
Wenjun Kuang, Hao Jin, Feng Yang, Xiying Chen, Jianzhao Liu, Ting Li, Yongxia Chang, Min Liu, Zhangqi Xu, Chun-Yue Huo, Xiaoyi Yan, Yuehong Yang, Wei Liu, Qi-Peng Shu, Shanshan Xie, Tianhua Zhou   +15 more
semanticscholar   +1 more source