Results 31 to 40 of about 9,541 (228)
Robust interaction of IFT70 with IFT52–IFT88 in the IFT-B complex is required for ciliogenesis
Biology Open, 2018 In the intraflagellar transport (IFT) machinery, the IFT-B and IFT-A complexes mediate anterograde and retrograde ciliary protein trafficking, respectively.
Ryota Takei +2 more
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Centrobin controls primary ciliogenesis in vertebrates [PDF]
Journal of Cell Biology, 2018 The BRCA2 interactor, centrobin, is a centrosomal protein that has been implicated in centriole duplication and microtubule stability. We used genome editing to ablate CNTROB in hTERT-RPE1 cells and observed an increased frequency of monocentriolar and acentriolar cells.
David C. A. Gaboriau +7 more
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Rapid Ex-Vivo Ciliogenesis and Dose-Dependent Effect of Notch Inhibition on Ciliogenesis of Respiratory Epithelia [PDF]
Biomolecules, 2020 Background: Cilia are actin based cellular protrusions conserved from algae to complex multicellular organisms like Homo sapiens. Respiratory motile cilia line epithelial cells of the tracheobronchial tree, beat in a synchronous, metachronal wave, moving inhaled pollutants and pathogens cephalad.
Maliha Zahid +5 more
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Cells, 2019 Centriolar satellites are non-membrane cytoplasmic granules that deliver proteins to centrosome during centrosome biogenesis and ciliogenesis. Centriolar satellites are highly dynamic during cell cycle or ciliogenesis and how they are regulated remains ...
Pengtao Wang +10 more
doaj +1 more source
Primary Cilia Formation Does Not Rely on WNT/β-Catenin Signaling
Frontiers in Cell and Developmental Biology, 2021 Primary cilia act as crucial regulators of embryo development and tissue homeostasis. They are instrumental for modulation of several signaling pathways, including Hedgehog, WNT, and TGF-β.
Ondrej Bernatik +4 more
doaj +1 more source
A Kinesin in Command of Primary Ciliogenesis [PDF]
Cell, 2011 Primary cilia sense extracellular cues and in response transmit signals required for development and tissue homeostasis. A new study by Kobayashi et al. (2011) reports that the kinesin Kif24 controls the formation of primary cilia by restricting the nucleation of cilia at centrioles.
openaire +3 more sources
Frontiers in Cell and Developmental Biology, 2022 Primary cilia have essential roles as signaling centers during development and adult homeostasis. Disruption of ciliary structure or function causes congenital human disorders called ciliopathies.
Hankyu Lee +12 more
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Clinical Case Reports, 2023 Variants in the C21orf2 (CFAP410) gene have recently been associated with the development of retinitis pigmentosa, an inherited condition characterized by degeneration of the retina.
Meagan Shinbashi +3 more
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Ciliary Vesicle Formation: A Prelude to Ciliogenesis [PDF]
Developmental Cell, 2015 Reporting recently in Nature Cell Biology, Lu et al. (2015) identify two Eps15-homology-domain-containing proteins as critical effectors of ciliary vesicle formation, an early event in ciliogenesis. Functional dissection reveals that one of them works to convert small vesicles associated with mother centriole distal appendages into a larger ciliary ...
Yee, Laura E, Reiter, Jeremy F
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NRF2 and Primary Cilia: An Emerging Partnership
Antioxidants, 2020 When not dividing, many cell types target their centrosome to the plasma membrane, where it nucleates assembly of a primary cilium, an antenna-like signaling structure consisting of nine concentric microtubule pairs surrounded by membrane.
Ana Martin-Hurtado +3 more
doaj +1 more source