Results 31 to 40 of about 19,567 (308)
Science Advances, 2022 Primary cilia are sensory antennae crucial for cell and organism development, and defects in their biogenesis cause ciliopathies. Ciliogenesis involves membrane trafficking mediated by small guanosine triphosphatases (GTPases) including Rabs, molecular ...
Rahul Kumar +5 more
semanticscholar +1 more source
Structures and functions of cilia during vertebrate embryo development
Molecular Reproduction and Development, Volume 89, Issue 12, Page 579-596, December 2022., 2022 Abstract Cilia are hair‐like structures that project from the surface of cells. In vertebrates, most cells have an immotile primary cilium that mediates cell signaling, and some specialized cells assemble one or multiple cilia that are motile and beat synchronously to move fluids in one direction.
Jeffrey D. Amack
wiley +1 more source
Ciliogenesis: Polarity Proteins on the Move [PDF]
Current Biology, 2004 The formation and maintenance of cilia and flagella require a selective and directed transport along the axoneme, a characteristic central bundle of microtubules. Recent evidence suggests an interesting link between the generation of cilia and the protein complexes that establish apico-basal cell polarity.
André Bachmann, Olaf Bossinger
openaire +3 more sources
Nonredundant roles of DIAPHs in primary ciliogenesis [PDF]
Journal of Biological Chemistry, 2021 Primary cilia are hubs for several signaling pathways, and disruption in cilia function and formation leads to a range of diseases collectively known as ciliopathies. Both ciliogenesis and cilia maintenance depend on vesicle trafficking along a network of microtubules and actin filaments toward the basal body.
Oliva Palander +4 more
openaire +2 more sources
Frontiers in Cell and Developmental Biology, 2020 Primary cilia are microtubule-based, antenna-like organelles, which are formed in G0 phase and resorbed as cells re-enter the cell cycle. It has been reported that primary cilia can influence the timing of cell cycle progression.
Huadong Jiang +7 more
doaj +1 more source
Centriolar satellites expedite mother centriole remodeling to promote ciliogenesis
bioRxiv, 2022 Centrosomes are orbited by centriolar satellites, dynamic multiprotein assemblies nucleated by PCM1. To study the requirement for centriolar satellites, we generated mice lacking PCM1.
Emma A. Hall +18 more
semanticscholar +1 more source
Frontiers in Cell and Developmental Biology, 2022 Primary cilia have essential roles as signaling centers during development and adult homeostasis. Disruption of ciliary structure or function causes congenital human disorders called ciliopathies.
Hankyu Lee +12 more
doaj +1 more source
Flagellar length control in biflagellate eukaryotes: time-of-flight, shared pool, train traffic and cooperative phenomena [PDF]
NEW JOURNAL OF PHYSICS, vol. 22, 083009 (2020), 2020 Flagella of eukaryotic cells are transient long cylindrical protrusions. The proteins needed to form and maintain flagella are synthesized in the cell body and transported to the distal tips. What `rulers' or `timers' a specific type of cells use to strike a balance between the outward and inward transport of materials so as to maintain a particular ...
arxiv +1 more source
Primary Cilia Formation Does Not Rely on WNT/β-Catenin Signaling
Frontiers in Cell and Developmental Biology, 2021 Primary cilia act as crucial regulators of embryo development and tissue homeostasis. They are instrumental for modulation of several signaling pathways, including Hedgehog, WNT, and TGF-β.
Ondrej Bernatik +4 more
doaj +1 more source
Traffic : the International Journal of Intracellular Transport, 2022 The endocytic protein EHD1 controls primary ciliogenesis by facilitating fusion of the ciliary vesicle and by removal of CP110 from the mother centriole.
Tyler A. Jones +2 more
semanticscholar +1 more source