Results 41 to 50 of about 21,394 (289)
Frontiers in Cell and Developmental Biology, 2020 Primary cilia are microtubule-based, antenna-like organelles, which are formed in G0 phase and resorbed as cells re-enter the cell cycle. It has been reported that primary cilia can influence the timing of cell cycle progression.
Huadong Jiang +7 more
doaj +1 more source
Tubb4b is required for multi-ciliogenesis in the mouse
Development, 2023 Cilia are microtubule (MT)-based organelles present on the surface of nearly all vertebrate cells. MTs are polymers of α- and β-tubulins that are each encoded by multiple, individual isotype genes.
Mycah T Sewell +2 more
semanticscholar +1 more source
Roles of the actin cytoskeleton in ciliogenesis.
Journal of Cell Science, 2022 Primary cilia play a key role in the ability of cells to respond to extracellular stimuli, such as signaling molecules and environmental cues. These sensory organelles are crucial to the development of many organ systems, and defects in primary ...
H. K. Hoffman, R. Prekeris
semanticscholar +1 more source
A meckelin–filamin A interaction mediates ciliogenesis [PDF]
Human Molecular Genetics, 2011 MKS3, encoding the transmembrane receptor meckelin, is mutated in Meckel-Gruber syndrome (MKS), an autosomal-recessive ciliopathy. Meckelin localizes to the primary cilium, basal body and elsewhere within the cell. Here, we found that the cytoplasmic domain of meckelin directly interacts with the actin-binding protein filamin A, potentially at the ...
Adams, M. +13 more
openaire +4 more sources
Roles for ELMOD2 and Rootletin in ciliogenesis [PDF]
Molecular Biology of the Cell, 2021 The ARF GAP ELMOD2, Rootletin, and ARL2 all act in a common pathway to suppress spurious ciliation upstream of CP110 and to maintain centrosome cohesion.
Turn, Rachel E. +5 more
openaire +3 more sources
Prenatal Diagnosis of Joubert Syndrome 23 With Left Isomerism: A Novel Phenotype Associated With Pathogenic KIAA0586 Variant. [PDF]
Prenat DiagnAbstract Joubert syndrome is a rare autosomal recessive ciliopathy defined by the “molar tooth” sign caused by cerebellar vermis hypoplasia and abnormal superior cerebellar peduncles. Over 40 genes are known to cause the disorder, including KIAA0586, which encodes the centrosomal protein TALPID3, essential for ciliogenesis and Hedgehog signaling ...
Casteleyn T +6 more
europepmc +2 more sources
Jasplakinolide induces primary cilium formation through cell rounding and YAP inactivation.
PLoS ONE, 2017 Primary cilia are non-motile cilia that serve as cellular antennae for sensing and transducing extracellular signals. In general, primary cilia are generated by cell quiescence signals.
Tomoaki Nagai, Kensaku Mizuno
doaj +1 more source
Ccdc11 is a novel centriolar satellite protein essential for ciliogenesis and establishment of left-right asymmetry [PDF]
, 2016 The establishment of left–right (L-R) asymmetry in vertebrates is dependent on the sensory and motile functions of cilia during embryogenesis. Mutations in CCDC11 disrupt L-R asymmetry and cause congenital heart disease in humans, yet the molecular and ...
Betleja, Ewelina +8 more
core +2 more sources
Human SFI1 and Centrin form a complex critical for centriole architecture and ciliogenesis
EMBO Journal, 2022 Over the course of evolution, the centrosome function has been conserved in most eukaryotes, but its core architecture has evolved differently in some clades, with the presence of centrioles in humans and a spindle pole body (SPB) in yeast.
Marine. H. Laporte +10 more
semanticscholar +1 more source
Functional interaction between autophagy and ciliogenesis [PDF]
Nature, 2013 Nutrient deprivation is a stimulus shared by both autophagy and the formation of primary cilia. The recently discovered role of primary cilia in nutrient sensing and signalling motivated us to explore the possible functional interactions between this signalling hub and autophagy.
Pampliega, Olatz +9 more
openaire +2 more sources