Results 41 to 50 of about 19,567 (308)

Enhanced primary ciliogenesis via mitochondrial oxidative stress activates AKT to prevent neurotoxicity in HSPA9/mortalin-depleted SH-SY5Y cells

Molecular Brain, 2023
The primary cilium, an antenna-like structure on the cell surface, acts as a mechanical and chemical sensory organelle. Primary cilia play critical roles in sensing the extracellular environment to coordinate various developmental and homeostatic ...
Ji-Eun Bae, Soyoung Jang, Joon Bum Kim, Hyejin Hyung, Na Yeon Park, Yong Hwan Kim, So Hyun Kim, Seong Hyun Kim, Jin Min Ha, Gyeong Seok Oh, Kyuhee Park, Kwiwan Jeong, Jae Seon Jang, Doo Sin Jo, Pansoo Kim, Hyun-Shik Lee, Zae Young Ryoo, Dong-Hyung Cho   +17 more
doaj   +1 more source

Arl13b and the exocyst interact synergistically in ciliogenesis [PDF]

Molecular Biology of the Cell, 2016
Arl13b belongs to the ADP-ribosylation factor family within the Ras superfamily of regulatory GTPases. Mutations in Arl13b cause Joubert syndrome, which is characterized by congenital cerebellar ataxia, hypotonia, oculomotor apraxia, and mental retardation.
Tamara Caspary, Alexandre Benmerah, Alexandre Benmerah, Michael P. East, Ben Fogelgren, Richard A. Kahn, Hugo Moreiras, Joshua H. Lipschutz, Joshua H. Lipschutz, Rania Ghossoub, Soo Young Choi, Nicole L. Umberger, Xiaofeng Zuo, Duarte C. Barral, Cecília Seixas, Noemi Polgar   +15 more
openaire   +3 more sources

Jasplakinolide induces primary cilium formation through cell rounding and YAP inactivation.

PLoS ONE, 2017
Primary cilia are non-motile cilia that serve as cellular antennae for sensing and transducing extracellular signals. In general, primary cilia are generated by cell quiescence signals.
Tomoaki Nagai, Kensaku Mizuno
doaj   +1 more source

A ciliopathy complex builds distal appendages to initiate ciliogenesis

bioRxiv, 2021
Cells inherit two centrioles, the older of which is uniquely capable of generating a cilium. Using proteomics and super-resolved imaging, we identified a module which we term DISCO (DIStal centriole COmplex). DISCO components CEP90, MNR and OFD1 underlie
Dhivya Kumar, Addison B Rains, V. Herranz-Pérez, Quanlong Lu, Xiaoyu Shi, D. Swaney, Erica Stevenson, N. Krogan, B. Huang, Christopher J Westlake, J. García-Verdugo, B. Yoder, Jeremy F. Reiter   +12 more
semanticscholar   +1 more source

Ccdc11 is a novel centriolar satellite protein essential for ciliogenesis and establishment of left-right asymmetry [PDF]

, 2016
The establishment of left–right (L-R) asymmetry in vertebrates is dependent on the sensory and motile functions of cilia during embryogenesis. Mutations in CCDC11 disrupt L-R asymmetry and cause congenital heart disease in humans, yet the molecular and ...
Betleja, Ewelina, John, Emily, Mahjoub, Moe R, Mitchell, Brian J, Moresco, James J, Silva, Erica, Spear, Philip, Yates, John R, III, Zhang, Siwei   +8 more
core   +2 more sources

Induction of Ran GTP drives ciliogenesis [PDF]

Molecular Biology of the Cell, 2011
The small GTPase Ran and the importin proteins regulate nucleocytoplasmic transport. New evidence suggests that Ran GTP and the importins are also involved in conveying proteins into cilia. In this study, we find that Ran GTP accumulation at the basal bodies is coordinated with the initiation of ciliogenesis.
Fan, Shuling, Whiteman, Eileen L, Hurd, Toby W, McIntyre, Jeremy C, Dishinger, John F, Liu, Chia Jen, Martens, Jeffrey R, Verhey, Kristen J, Sajjan, Uma, Margolis, Ben   +9 more
openaire   +3 more sources

The snRNA-processing complex, Integrator, is required for ciliogenesis and dynein recruitment to the nuclear envelope via distinct mechanisms

Biology Open, 2013
Summary We previously reported that the small nuclear RNA processing complex, Integrator, is required for dynein recruitment to the nuclear envelope at mitotic onset in cultured human cells.
Jeanne N. Jodoin, Mohammad Shboul, Todd R. Albrecht, Ethan Lee, Eric J. Wagner, Bruno Reversade, Laura A. Lee   +6 more
doaj   +1 more source

A systems-biology approach to understanding the ciliopathy disorders. [PDF]

, 2011
'Ciliopathies' are an emerging class of genetic multisystemic human disorders that are caused by a multitude of largely unrelated genes that affect ciliary structure/function.
Gleeson, Joseph G, Lee, Ji Eun
core   +1 more source

The TBC1D31/praja2 complex controls primary ciliogenesis through PKA‐directed OFD1 ubiquitylation

EMBO Journal, 2021
The primary cilium is a microtubule‐based sensory organelle that dynamically links signalling pathways to cell differentiation, growth, and development.
Emanuela Senatore, F. Chiuso, L. Rinaldi, Daniela Intartaglia, Rossella Delle Donne, E. Pedone, B. Catalanotti, L. Pirone, Bianca Fiorillo, Federica Moraca, Giuliana Giamundo, G. Scala, Andrea Raffeiner, O. Torres-Quesada, E. Stefan, M. Kwiatkowski, Alienke van Pijkeren, M. Morleo, B. Franco, C. Garbi, I. Conte, A. Feliciello   +21 more
semanticscholar   +1 more source

Mechanisms of ciliogenesis suppression in dividing cells [PDF]

Cellular and Molecular Life Sciences, 2016
The primary cilium is a non-motile and microtubule-enriched protrusion ensheathed by plasma membrane. Primary cilia function as mechano/chemosensors and signaling hubs and their disorders predispose to a wide spectrum of human diseases. Most types of cells assemble their primary cilia in response to cellular quiescence, whereas they start to retract ...
Hironori Inaba, Masaki Inagaki, Hidemasa Goto   +2 more
openaire   +3 more sources