Results 51 to 60 of about 21,394 (289)

Wnt3a Stimulation Promotes Primary Ciliogenesis through β-Catenin Phosphorylation-Induced Reorganization of Centriolar Satellites

Cell Reports, 2020
Summary: Primary cilium is an antenna-like microtubule-based cellular sensing structure. Abnormal regulation of the dynamic assembly and disassembly cycle of primary cilia is closely related to ciliopathy and cancer.
Mi-Lang Kyun, Sun-Ok Kim, Hee Gu Lee, Jeong-Ah Hwang, Joonsung Hwang, Nak-Kyun Soung, Hyunjoo Cha-Molstad, Sangku Lee, Yong Tae Kwon, Bo Yeon Kim, Kyung Ho Lee   +10 more
doaj   +1 more source

Rab8a and Rab8b are essential for several apical transport pathways but insufficient for ciliogenesis [PDF]

, 2013
The small GTP-binding protein Rab8 is known to play an essential role in intracellular transport and cilia formation. We have previously demonstrated that Rab8a is required for localising apical markers in various organisms.
A. Harada, H. Hagiwara, M. Kunii, M. Yuzaki, R. Harada, R. Mizuguchi, S. Matsuda, T. Iwano, T. Sato, Y. Jung, Y. Yoshihara   +10 more
core   +2 more sources

Ciliogenesis requires sphingolipid-dependent membrane and axoneme interaction

Proceedings of the National Academy of Sciences of the United States of America, 2022
Significance Using ribosome profiling of cilia regeneration in green algae Chlamydomonas, we uncovered that ciliary genes undergo an early transcriptional activation and late translational suppression, the pattern of which guided us to identify serine ...
Dou Wu, Jingying Huang, Hao Zhu, Zhe Chen, Yongping Chai, Jin-ju Ke, Kexin Lei, Zhao Peng, Ranhao Zhang, Xueming Li, Kaiyao Huang, Wei Li, Chengtian Zhao, Guangshuo Ou   +13 more
semanticscholar   +1 more source

Basal body stability and ciliogenesis requires the conserved component Poc1 [PDF]

, 2009
Centrioles are the foundation for centrosome and cilia formation. The biogenesis of centrioles is initiated by an assembly mechanism that first synthesizes the ninefold symmetrical cartwheel and subsequently leads to a stable cylindrical microtubule ...
Abal, Andersen, Avidor-Reiss, Azimzadeh, Badano, Bakowska, Balczon, Baron, Basmussen, Basto, Beisson, Berbari, Blachon, Bobinnec, Bobinnec, Broadhead, Brown, Bruns, Chad G. Pearson, Cheeseman, Culver, Dammermann, Dammermann, Daniel P.S. Osborn, Dupuis-Williams, Dutcher, Dutcher, Dutcher, Eddé, Eggenschwiler, Essner, Fry, Gaertig, Garreau de Loubresse, Gerdes, Graser, Gundersen, Hai, Hames, Hentschel, Hildebrandt, Hiraki, Jerka-Dziadosz, Kaczanowski, Keller, Keller, Kilburn, Kirkham, Kochanski, Le Clech, Leidel, Leidel, Leidel, Li, Liu, Mark Winey, Marshall, Marshall, Martinez-Campos, Matsuura, Million, Mottier-Pavie, Nakazawa, Nanney, Neuhauss, Orias, Paoletti, Pearson, Pearson, Pelletier, Peterkin, Philip L. Beales, Piperno, Rodrigues-Martins, Salisbury, Shang, Shang, Stemm-Wolf, Strnad, Thomas H. Giddings, Tobin, Tobin, Vladar, Westerfield, Wilkinson, Williams, Wloga, Woodland   +87 more
core   +2 more sources

The snRNA-processing complex, Integrator, is required for ciliogenesis and dynein recruitment to the nuclear envelope via distinct mechanisms

Biology Open, 2013
Summary We previously reported that the small nuclear RNA processing complex, Integrator, is required for dynein recruitment to the nuclear envelope at mitotic onset in cultured human cells.
Jeanne N. Jodoin, Mohammad Shboul, Todd R. Albrecht, Ethan Lee, Eric J. Wagner, Bruno Reversade, Laura A. Lee   +6 more
doaj   +1 more source

NEK9 regulates primary cilia formation by acting as a selective autophagy adaptor for MYH9/myosin IIA

Nature Communications, 2021
Ciliogenesis is a tightly regulated process, although the role of selective autophagy is unclear. Here, the authors show NIMA-related kinase 9 controls actin network stabilization and subsequently ciliogenesis by targeting myosin MYH9 for autophagic ...
Yasuhiro Yamamoto, Haruka Chino, Satoshi Tsukamoto, Koji L. Ode, Hiroki R. Ueda, Noboru Mizushima   +5 more
doaj   +1 more source

Length-dependent disassembly maintains four different flagellar lengths in Giardia. [PDF]

, 2019
With eight flagella of four different lengths, the parasitic protist Giardia is an ideal model to evaluate flagellar assembly and length regulation. To determine how four different flagellar lengths are maintained, we used live-cell quantitative imaging ...
Aurrecoechea, Avidor-Reiss, Avidor-Reiss, Ball, Barker, Berman, Bertiaux, Blaineau, Bradley, Briggs, Brooks, Buchel, Buisson, Chan, Chien, Cole, Cooper, Coyne, Craft, Dawson, Deane, Desai, Ellenberg, Engel, Fai, Gibson, Gourguechon, Hagen, Hao, Hardin, Helenius, Hendel, Hilton, Hoeng, Hunter, Ishikawa, Kozminski, Lechtreck, Lenaghan, Ludington, Ludington, Mangeol, Manning, Marshall, Marshall, McInally, McInally, Meng, Mohapatra, Naoz, Nohynková, Pazour, Pazour, Piao, Reiter, Rosenbaum, Sagolla, Schindelin, Shaner, Sung, Tamm, Vasudevan, Walczak, Wang, Wei, Williams, Wingfield, Wloga, Woessner, Wren   +69 more
core   +2 more sources

Kinesin-2 family in vertebrate ciliogenesis [PDF]

Proceedings of the National Academy of Sciences, 2012
The differentiation of cilia is mediated by kinesin-driven transport. As the function of kinesins in vertebrate ciliogenesis is poorly characterized, we decided to determine the role of kinesin-2 family motors—heterotrimeric kinesin-II and the homodimeric Kif17 kinesin—in zebrafish cilia.
Chengtian, Zhao, Yoshihiro, Omori, Katarzyna, Brodowska, Peter, Kovach, Jarema, Malicki   +4 more
openaire   +2 more sources

A cell-based GEF assay reveals new substrates for DENN domains and a role for DENND2B in primary ciliogenesis

Science Advances, 2022
Primary cilia are sensory antennae crucial for cell and organism development, and defects in their biogenesis cause ciliopathies. Ciliogenesis involves membrane trafficking mediated by small guanosine triphosphatases (GTPases) including Rabs, molecular ...
Rahul Kumar, V. Francis, Gopinath Kulasekaran, MA Khan, Gary A. B. Armstrong, P. McPherson   +5 more
semanticscholar   +1 more source

Genotoxic stress-activated DNA-PK-p53 cascade and autophagy cooperatively induce ciliogenesis to maintain the DNA damage response

Cell Death and Differentiation, 2021
The DNA-PK maintains cell survival when DNA damage occurs. In addition, aberrant activation of the DNA-PK induces centrosome amplification, suggesting additional roles for this kinase.
Ting‐Yu Chen, B. Huang, T. Tang, Yu-Ying Chao, X. Xiao, Pei-Rong Lee, Li-Yun Yang, Chia‐Yih Wang   +7 more
semanticscholar   +1 more source