Results 61 to 70 of about 21,394 (289)
Ciliogenesis: Polarity Proteins on the Move [PDF]
Current Biology, 2004 The formation and maintenance of cilia and flagella require a selective and directed transport along the axoneme, a characteristic central bundle of microtubules. Recent evidence suggests an interesting link between the generation of cilia and the protein complexes that establish apico-basal cell polarity.
Bossinger, Olaf, Bachmann, André
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VDAC3 and Mps1 negatively regulate ciliogenesis [PDF]
Cell Cycle, 2013 Centrosomes serve to organize new centrioles in cycling cells, whereas in quiescent cells they assemble primary cilia. We have recently shown that the mitochondrial porin VDAC3 is also a centrosomal protein that is predominantly associated with the mother centriole and modulates centriole assembly by recruiting Mps1 to centrosomes.
Shubhra, Majumder, Harold A, Fisk
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Nonredundant roles of DIAPHs in primary ciliogenesis [PDF]
Journal of Biological Chemistry, 2021 Primary cilia are hubs for several signaling pathways, and disruption in cilia function and formation leads to a range of diseases collectively known as ciliopathies. Both ciliogenesis and cilia maintenance depend on vesicle trafficking along a network of microtubules and actin filaments toward the basal body.
Oliva Palander +4 more
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A ciliopathy complex builds distal appendages to initiate ciliogenesis
bioRxiv, 2021 Cells inherit two centrioles, the older of which is uniquely capable of generating a cilium. Using proteomics and super-resolved imaging, we identified a module which we term DISCO (DIStal centriole COmplex). DISCO components CEP90, MNR and OFD1 underlie
Dhivya Kumar +12 more
semanticscholar +1 more source
Prostaglandin signaling in ciliogenesis during development [PDF]
Cell Cycle, 2014 Prostaglandins regulate a wide variety of physiological and pathological processes, including inflammation, reproduction, cardiovascular homeostasis, and cancer progression. Cyclooxygenase (COX) catalyzes the rate-limiting step in the production of prostaglandins from arachidonic acid (Fig. 1). In 2 reaction steps, arachidonic acid is firstly converted
Daqing, Jin, Peiyun, Liu, Tao P, Zhong
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Induction of Ran GTP drives ciliogenesis
Molecular Biology of the Cell, 2011 The small GTPase Ran and the importin proteins regulate nucleocytoplasmic transport. New evidence suggests that Ran GTP and the importins are also involved in conveying proteins into cilia. In this study, we find that Ran GTP accumulation at the basal bodies is coordinated with the initiation of ciliogenesis.
Fan, Shuling +9 more
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Shortened primary cilium length and dysregulated Sonic hedgehog signaling in Niemann-Pick C1 disease [PDF]
, 2017 The Niemann-Pick type C1 (NPC1) disease is a neurodegenerative lysosomal storage disorder due to mutations in the NPC1 gene, encoding a transmembrane protein related to the Sonic hedgehog receptor, Patched, and involved in intracellular trafficking of ...
Canterini, Sonia +7 more
core +1 more source
Coordination of IFT20 With Other IFT Components Is Required for Ciliogenesis. [PDF]
J Clin Lab AnalWang W +6 more
europepmc +3 more sources
FGF2 is expressed in human and murine embryonic choroid plexus and affects choroid plexus cell behaviour [PDF]
, 2008 Background Although fibroblast growth factor (Fgf) signalling plays crucial roles in several developing and mature tissues, little information is currently available on expression of Fgf2 during early choroid plexus development and whether Fgf2 directly ...
Ferretti, P. +4 more
core +3 more sources
International Journal of Molecular Sciences, 2022 Ataluren and Gentamicin are translational readthrough drugs (TRIDs) that induce premature termination codon (PTC) readthrough, resulting in the production of full-length proteins that usually harbor a single missense substitution.
Avigail Beryozkin +6 more
semanticscholar +1 more source