Results 61 to 70 of about 19,567 (308)

NEK9 regulates primary cilia formation by acting as a selective autophagy adaptor for MYH9/myosin IIA

Nature Communications, 2021
Ciliogenesis is a tightly regulated process, although the role of selective autophagy is unclear. Here, the authors show NIMA-related kinase 9 controls actin network stabilization and subsequently ciliogenesis by targeting myosin MYH9 for autophagic ...
Yasuhiro Yamamoto, Haruka Chino, Satoshi Tsukamoto, Koji L. Ode, Hiroki R. Ueda, Noboru Mizushima   +5 more
doaj   +1 more source

Centrobin controls primary ciliogenesis in vertebrates [PDF]

Journal of Cell Biology, 2018
The BRCA2 interactor, centrobin, is a centrosomal protein that has been implicated in centriole duplication and microtubule stability. We used genome editing to ablate CNTROB in hTERT-RPE1 cells and observed an increased frequency of monocentriolar and acentriolar cells.
David C. A. Gaboriau, David C. A. Gaboriau, Ciaran G. Morrison, Yetunde Adesanya Ogungbenro, Pierce Lalor, Peter Dockery, Teresa Casar Tena, Melanie Philipp   +7 more
openaire   +4 more sources

Functional Alterations in Ciliogenesis-Associated Kinase 1 (CILK1) that Result from Mutations Linked to Juvenile Myoclonic Epilepsy

Cells, 2020
Ciliopathies are a group of human genetic disorders associated with mutations that give rise to the dysfunction of primary cilia. Ciliogenesis-associated kinase 1 (CILK1), formerly known as intestinal cell kinase (ICK), is a conserved serine and ...
Eric J. Wang, Casey D. Gailey, David L. Brautigan, Zheng Fu   +3 more
doaj   +1 more source

Uni-directional ciliary membrane protein trafficking by a cytoplasmic retrograde IFT motor and ciliary ectosome shedding [PDF]

, 2015
The role of the primary cilium in key signaling pathways depends on dynamic regulation of ciliary membrane protein composition, yet we know little about the motors or membrane events that regulate ciliary membrane protein trafficking in existing ...
Adair, Bakeberg, Belzile, Bergman, Cao, Chacon-Heszele, Chih, Dentler, Dorn, Engel, Ferris, Firestone, Garcia-Gonzalo, Gerdes, Goetz, Goodenough, Goodenough, Hildebrandt, Hogan, Hu, Hunnicutt, Hunnicutt, Hyman, Kim, Kong, Kubo, Lancaster, Lin, Liu, Liu, Malicki, Meng, Milenkovic, Molla-Herman, Mukhopadhyay, Mukhopadhyay, Nachury, Ning, Ocbina, Pasquale, Pazour, Pazour, Pedersen, Pijst, Pijst, Rohatgi, Rohatgi, Rosenbaum, Sang, Shih, Snell, Snell, Snell, Tai, Wang, Wang, Wang, Weise, Wiese, Williams, Wilson, Wood, Wood, Ye   +63 more
core   +3 more sources

LUBAC regulates ciliogenesis by promoting CP110 removal from the mother centriole

Journal of Cell Biology, 2021
Shen et al. identify the linear ubiquitin ligase complex LUBAC as a novel regulator of ciliogenesis and further mechanistically explain that LUBAC regulates ciliogenesis by promoting the removal of CP110 on the mother centriole.
Xiao-Lin Shen, Jin-Feng Yuan, Xuanhe Qin, Guang-Ping Song, Huaibin Hu, Hai-Qing Tu, Zeng-Qing Song, Pei-Yao Li, Yu-Ling Xu, Sen Li, Xiao-Xiao Jian, Jia-Ning Li, Chun-Yu He, Xi-Ping Yu, Li-Yun Liang, Min Wu, Qiu-Ying Han, Kai Wang, Ai-ling Li, Tao Zhou, Yu-Cheng Zhang, Na Wang, Hui-Yan Li   +22 more
semanticscholar   +1 more source

A Kinesin in Command of Primary Ciliogenesis [PDF]

Cell, 2011
Primary cilia sense extracellular cues and in response transmit signals required for development and tissue homeostasis. A new study by Kobayashi et al. (2011) reports that the kinesin Kif24 controls the formation of primary cilia by restricting the nucleation of cilia at centrioles.
openaire   +3 more sources

Ciliary Vesicle Formation: A Prelude to Ciliogenesis [PDF]

Developmental Cell, 2015
Reporting recently in Nature Cell Biology, Lu et al. (2015) identify two Eps15-homology-domain-containing proteins as critical effectors of ciliary vesicle formation, an early event in ciliogenesis. Functional dissection reveals that one of them works to convert small vesicles associated with mother centriole distal appendages into a larger ciliary ...
Yee, Laura E, Reiter, Jeremy F
openaire   +5 more sources

Rapid Ex-Vivo Ciliogenesis and Dose-Dependent Effect of Notch Inhibition on Ciliogenesis of Respiratory Epithelia [PDF]

Biomolecules, 2020
Background: Cilia are actin based cellular protrusions conserved from algae to complex multicellular organisms like Homo sapiens. Respiratory motile cilia line epithelial cells of the tracheobronchial tree, beat in a synchronous, metachronal wave, moving inhaled pollutants and pathogens cephalad.
Maliha Zahid, Timothy N. Feinstein, Anthony Oro, Molly Schwartz, Alex D. Lee, Cecilia W. Lo   +5 more
openaire   +6 more sources

SNX17 Recruits USP9X to Antagonize MIB1-Mediated Ubiquitination and Degradation of PCM1 during Serum-Starvation-Induced Ciliogenesis

Cells, 2019
Centriolar satellites are non-membrane cytoplasmic granules that deliver proteins to centrosome during centrosome biogenesis and ciliogenesis. Centriolar satellites are highly dynamic during cell cycle or ciliogenesis and how they are regulated remains ...
Pengtao Wang, Jianhong Xia, Leilei Zhang, Shaoyang Zhao, Shengbiao Li, Haiyun Wang, Shan Cheng, Heying Li, Wenguang Yin, Duanqing Pei, Xiaodong Shu   +10 more
doaj   +1 more source

Phosphorylation and Ubiquitylation Regulate Protein Trafficking, Signaling, and the Biogenesis of Primary Cilia

Frontiers in Cell and Developmental Biology, 2021
The primary cilium is a solitary, microtubule-based membrane protrusion extending from the surface of quiescent cells that senses the cellular environment and triggers specific cellular responses.
Elena A. May, Elena A. May, Tommy J. Sroka, Tommy J. Sroka, David U. Mick, David U. Mick   +5 more
doaj   +1 more source