Results 71 to 80 of about 21,394 (289)

Cell Cycle–Dependent Ciliogenesis and Cancer [PDF]

Cancer Research, 2008
Abstract In mammals, most cell types have primary cilia, protruding structures involved in sensing mechanical and chemical signals from the extracellular environment that act as major communication hubs for signaling controlling cell differentiation and polarity.
Olga V, Plotnikova, Erica A, Golemis, Elena N, Pugacheva   +2 more
openaire   +2 more sources

SNX17 Recruits USP9X to Antagonize MIB1-Mediated Ubiquitination and Degradation of PCM1 during Serum-Starvation-Induced Ciliogenesis

Cells, 2019
Centriolar satellites are non-membrane cytoplasmic granules that deliver proteins to centrosome during centrosome biogenesis and ciliogenesis. Centriolar satellites are highly dynamic during cell cycle or ciliogenesis and how they are regulated remains ...
Pengtao Wang, Jianhong Xia, Leilei Zhang, Shaoyang Zhao, Shengbiao Li, Haiyun Wang, Shan Cheng, Heying Li, Wenguang Yin, Duanqing Pei, Xiaodong Shu   +10 more
doaj   +1 more source

A novel Cep120-dependent mechanism inhibits centriole maturation in quiescent cells [PDF]

, 2018
The two centrioles of the centrosome in quiescent cells are inherently asymmetric structures that differ in age, morphology and function. How these asymmetric properties are established and maintained during quiescence remains unknown. Here, we show that
Betleja, Ewelina, Cheng, Tao, Mahjoub, Moe R, Nanjundappa, Rashmi   +3 more
core   +2 more sources

Combined exome and whole-genome sequencing identifies mutations in ARMC4 as a cause of primary ciliary dyskinesia with defects in the outer dynein arm [PDF]

, 2013
Primary ciliary dyskinesia (PCD) is a rare, genetically heterogeneous ciliopathy disorder affecting cilia and sperm motility. A range of ultrastructural defects of the axoneme underlie the disease, which is characterised by chronic respiratory symptoms ...
Alexandros Onoufriadis, Amelia Shoemark, Anthony T Moore, Antony, Bush, Chela T James, Chiara Bacchelli, Claire Hogg, Eddie M K Chung, Elisabeth M Rosser, Fliegauf, Gerard Pals, Gherman, Hannah M Mitchison, Hirst, Hjeij, Hozumi, Jeannette E Danke-Roelse, John J Sloper, Kennedy, Knowles, Loges, Lonergan, Miriam Schmidts, Mitali Patel, Mustafa M Munye, O'Toole, Olbrich, Ong, Onoufriadis, Papon, Peter J Scambler, Philip L Beales, Plagnol, Richard D Emes, Roy, Sarah Hull, Schultz, Shoemark, Speder, Stephen L Hart, Tarkar, Tewari, Xu, Yang, Zhang   +45 more
core   +3 more sources

Differential requirements for the Eps15 homology domain proteins EHD4 and EHD2 in the regulation of mammalian ciliogenesis

Traffic : the International Journal of Intracellular Transport, 2022
The endocytic protein EHD1 controls primary ciliogenesis by facilitating fusion of the ciliary vesicle and by removal of CP110 from the mother centriole.
Tyler A. Jones, Naava Naslavsky, S. Caplan   +2 more
semanticscholar   +1 more source

The TBC1D31/praja2 complex controls primary ciliogenesis through PKA‐directed OFD1 ubiquitylation

EMBO Journal, 2021
The primary cilium is a microtubule‐based sensory organelle that dynamically links signalling pathways to cell differentiation, growth, and development.
Emanuela Senatore, F. Chiuso, L. Rinaldi, Daniela Intartaglia, Rossella Delle Donne, E. Pedone, B. Catalanotti, L. Pirone, Bianca Fiorillo, Federica Moraca, Giuliana Giamundo, G. Scala, Andrea Raffeiner, O. Torres-Quesada, E. Stefan, M. Kwiatkowski, Alienke van Pijkeren, M. Morleo, B. Franco, C. Garbi, I. Conte, A. Feliciello   +21 more
semanticscholar   +1 more source

Phosphorylation and Ubiquitylation Regulate Protein Trafficking, Signaling, and the Biogenesis of Primary Cilia

Frontiers in Cell and Developmental Biology, 2021
The primary cilium is a solitary, microtubule-based membrane protrusion extending from the surface of quiescent cells that senses the cellular environment and triggers specific cellular responses.
Elena A. May, Elena A. May, Tommy J. Sroka, Tommy J. Sroka, David U. Mick, David U. Mick   +5 more
doaj   +1 more source

A role for Gle1, a regulator of DEAD-box RNA helicases, at centrosomes and basal bodies. [PDF]

, 2017
Control of organellar assembly and function is critical to eukaryotic homeostasis and survival. Gle1 is a highly conserved regulator of RNA-dependent DEAD-box ATPase proteins, with critical roles in both mRNA export and translation.
Akef, Abdalla, Jao, Li-En, Wente, Susan R   +2 more
core   +1 more source

Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis

eLife, 2017
We previously reported that Parkinson’s disease (PD) kinase LRRK2 phosphorylates a subset of Rab GTPases on a conserved residue in their switch-II domains (Steger et al., 2016) (PMID: 26824392). Here, we systematically analyzed the Rab protein family and
Martin Steger, Federico Diez, H. S. Dhekne, P. Lis, R. Nirujogi, Ozge Karayel, F. Tonelli, Terina N. Martinez, E. Lorentzen, S. Pfeffer, D. Alessi, M. Mann   +11 more
semanticscholar   +1 more source

Functional Alterations in Ciliogenesis-Associated Kinase 1 (CILK1) that Result from Mutations Linked to Juvenile Myoclonic Epilepsy

Cells, 2020
Ciliopathies are a group of human genetic disorders associated with mutations that give rise to the dysfunction of primary cilia. Ciliogenesis-associated kinase 1 (CILK1), formerly known as intestinal cell kinase (ICK), is a conserved serine and ...
Eric J. Wang, Casey D. Gailey, David L. Brautigan, Zheng Fu   +3 more
doaj   +1 more source