Results 71 to 80 of about 9,541 (228)
VDAC3 and Mps1 negatively regulate ciliogenesis [PDF]
Cell Cycle, 2013 Centrosomes serve to organize new centrioles in cycling cells, whereas in quiescent cells they assemble primary cilia. We have recently shown that the mitochondrial porin VDAC3 is also a centrosomal protein that is predominantly associated with the mother centriole and modulates centriole assembly by recruiting Mps1 to centrosomes.
Shubhra Majumder, Harold A. Fisk
openaire +3 more sources
Plant, Cell &Environment, EarlyView.ABSTRACT Deep sequencing of ribosome footprints, also known as ribosome profiling (Ribo‐seq), enables the quantification of mRNA translation and a comprehensive view of the translatome landscape. Here, we report an optimised Ribo‐seq protocol and analysis pipeline for the model green alga, Chlamydomonas reinhardtiii (Chlamydomonas).
Yen‐Ling Lin +4 more
wiley +1 more source
Stages of ciliogenesis and regulation of ciliary length [PDF]
Differentiation, 2012 Cilia and flagella are highly conserved eukaryotic microtubule-based organelles that protrude from the surface of most mammalian cells. These structures require large protein complexes and motors for distal addition of tubulin and extension of the ciliary membrane. In order for ciliogenesis to occur, coordination of many processes must take place.
Prachee Avasthi, Wallace F. Marshall
openaire +3 more sources
Photochemistry and Photobiology, EarlyView.Exposure to solar ultraviolet radiation is the main etiologic driver of nonmelanoma skin cancers (NMSCs), including basal cell (BCC) and cutaneous squamous cell carcinomas (cSCC), which are the most prevalent types of cancers in the US. In this study, we demonstrate that the serine/threonine kinase Polo‐like kinase 4 (PLK4) is overexpressed in NMSCs ...
Mary A. Ndiaye +5 more
wiley +1 more source
Ciliogenesis, Ciliary Function, and Selective Isolation [PDF]
ACS Chemical Biology, 2008 In addition to their classic role in cell motility, certain cilia have sensory or signaling functions. In sea urchin embryos, short motile cilia randomly propel the early embryo, while a group of long, immotile cilia appear later, coincident with directional swimming and localized within a region that gives rise to the larval nervous system.
openaire +3 more sources
The IN/OUT assay: a new tool to study ciliogenesis [PDF]
Cilia, 2016 Nearly all cells have a primary cilia on their surface, which functions as a cellular antennae. Primary cilia assembly begins intracellularly and eventually emerges extracellularly. However, current ciliogenesis assays, which detect cilia length and number, do not monitor ciliary stages.We developed a new assay that detects antibody access to a ...
Derek Toomre +2 more
openaire +2 more sources
Mitochondrial control of ciliary gene expression and structure in striatal neurons
The Journal of Physiology, EarlyView.Abstract figure legend Neurons drive animal behaviour by receiving and transmitting information and require energy, primarily supplied by mitochondria, to function. Additionally, neurons need to sense environmental changes to adapt, a function that is locally played by the primary cilia.
Dogukan H. Ulgen +5 more
wiley +1 more source
Dynein-2 intermediate chains play crucial but distinct roles in primary cilia formation and function
eLife, 2018 The dynein-2 microtubule motor is the retrograde motor for intraflagellar transport. Mutations in dynein-2 components cause skeletal ciliopathies, notably Jeune syndrome. Dynein-2 contains a heterodimer of two non-identical intermediate chains, WDR34 and
Laura Vuolo +3 more
doaj +1 more source
Ciliogenesis and the DNA damage response: a stressful relationship [PDF]
Cilia, 2016 Both inherited and sporadic mutations can give rise to a plethora of human diseases. Through myriad diverse cellular processes, sporadic mutations can arise through a failure to accurately replicate the genetic code or by inaccurate separation of duplicated chromosomes into daughter cells. The human genome has therefore evolved to encode a large number
Johnson, C.A., Collis, S.J.
openaire +3 more sources
Cell Proliferation, Volume 58, Issue 7, July 2025.Our results suggested that mitochondria‐accelerated motile cilia intraflagellar transport may be involved in endometrial microenvironment establishment. ABSTRACT The lack of accurate understanding of cellular physiology and pathophysiology during the WOI constitutes the major obstacle to correct diagnosis and treatment for patients with recurrent ...
Haoxuan Yang +17 more
wiley +1 more source