Results 81 to 90 of about 19,567 (308)

Prostaglandin signaling in ciliogenesis during development [PDF]

Cell Cycle, 2014
Prostaglandins regulate a wide variety of physiological and pathological processes, including inflammation, reproduction, cardiovascular homeostasis, and cancer progression. Cyclooxygenase (COX) catalyzes the rate-limiting step in the production of prostaglandins from arachidonic acid (Fig. 1). In 2 reaction steps, arachidonic acid is firstly converted
Tao P. Zhong, Daqing Jin, Peiyun Liu
openaire   +3 more sources

In Vitro Modeling Using Ciliopathy-Patient-Derived Cells Reveals Distinct Cilia Dysfunctions Caused by CEP290 Mutations

Cell Reports, 2017
Mutations in CEP290, a transition zone protein in primary cilia, cause diverse ciliopathies, including Leber congenital amaurosis (LCA) and Joubert-syndrome and related disorders (JSRD).
Hiroko Shimada, Quanlong Lu, Christine Insinna-Kettenhofen, Kunio Nagashima, Milton A. English, Elizabeth M. Semler, Jacklyn Mahgerefteh, Artur V. Cideciyan, Tiansen Li, Brian P. Brooks, Meral Gunay-Aygun, Samuel G. Jacobson, Tiziana Cogliati, Christopher J. Westlake, Anand Swaroop   +14 more
doaj   +1 more source

The ciliary GTPase Arl13b regulates cell migration and cell cycle progression [PDF]

, 2016
Acknowledgments We acknowledge Prof. Tamara Caspary from Emory University for kindly providing the cell lines, Linda Duncan from the University of Aberdeen Ian Fraser Cytometry Center for help with flow cytometry.
Clancy, Hannah, Ding, Yu-Qiang, Lang, Bing, McCaig, Colin D., Pruski, Michal, Rajnicek, Ann, Yang, Zhifu   +6 more
core   +2 more sources

Disrupted alternative splicing for genes implicated in splicing and ciliogenesis causes PRPF31 retinitis pigmentosa

Nature Communications, 2018
Mutations in pre-mRNA processing factors (PRPFs) cause autosomal-dominant retinitis pigmentosa (RP), but it is unclear why mutations in ubiquitously expressed genes cause non-syndromic retinal disease.
A. Buskin, Lili Zhu, V. Chichagova, Basudha Basu, S. Mozaffari-Jovin, David Dolan, A. Droop, J. Collin, Revital Bronstein, Sudeep Mehrotra, M. Farkas, Gerrit Hilgen, K. White, K. Pan, A. Treumann, D. Hallam, K. Bialas, Git W. Chung, Carla B. Mellough, Yuchun Ding, N. Krasnogor, S. Przyborski, S. Zwolinski, J. Al-Aama, Sameer E. Alharthi, Yaobo Xu, G. Wheway, K. Szymanska, M. Mckibbin, C. Inglehearn, D. Elliott, S. Lindsay, R. Ali, D. Steel, L. Armstrong, E. Sernagor, H. Urlaub, E. Pierce, R. Lührmann, S. Grellscheid, Colin A. Johnson, M. Lako   +41 more
semanticscholar   +1 more source

Exploring the role of fallopian ciliated cells in the pathogenesis of high-grade serous ovarian cancer [PDF]

, 2018
High-grade serous epithelial ovarian cancer (HGSOC) is the fifth leading cause of cancer death in women and the first among gynecological malignancies. Despite an initial response to standard chemotherapy, most HGSOC patients relapse.
Baldassarre G, Bianchet R, Cesaratto L, Coan M, Dassi E, Gardenal E, Nicoloso MS, Rampioni Vinciguerra GL, Spizzo R, Vecchione A   +9 more
core   +1 more source

C21orf2 variants causing inherited retinal disease: A review of what we know and a report of two new suspected cases

Clinical Case Reports, 2023
Variants in the C21orf2 (CFAP410) gene have recently been associated with the development of retinitis pigmentosa, an inherited condition characterized by degeneration of the retina.
Meagan Shinbashi, Ann Jewell, Jessica Randolph, Natario Couser   +3 more
doaj   +1 more source

Atrioventricular canal defect and genetic syndromes: the unifying role of sonic hedgehog [PDF]

, 2019
The atrioventricular canal defect (AVCD) is a congenital heart defect (CHD) frequently associated with extracardiac anomalies (75%). Previous observations from a personal series of patients with AVCD and "polydactyly syndromes" showed that the distinct ...
Baban, A, Calcagni, G, Dallapiccola, B, De Luca, A, Dentici, M L, Digilio, M C, Marino, B, Pugnaloni, F, Tartaglia, M, Versacci, P   +9 more
core   +1 more source

The Cdc14B phosphatase contributes to ciliogenesis in zebrafish [PDF]

Development, 2011
Progression through the cell cycle relies on oscillation of cyclin-dependent kinase (Cdk) activity. One mechanism for downregulating Cdk signaling is to activate opposing phosphatases. The Cdc14 family of phosphatases counteracts Cdk1 phosphorylation in diverse organisms to allow proper exit from mitosis and cytokinesis.
Lilianna Solnica-Krezel, Lilianna Solnica-Krezel, Kathleen L. Gould, Aurélie Clément   +3 more
openaire   +4 more sources

GJA1 depletion causes ciliary defects by affecting Rab11 trafficking to the ciliary base

eLife, 2022
The gap junction complex functions as a transport channel across the membrane. Among gap junction subunits, gap junction protein α1 (GJA1) is the most commonly expressed subunit.
Dong Gil Jang, Keun Yeong Kwon, Yeong Cheon Kweon, Byung-gyu Kim, Kyungjae Myung, Hyun-Shik Lee, Chan Young Park, Taejoon Kwon, Tae Joo Park   +8 more
doaj   +1 more source

UFMylation Modulates OFIP Stability and Centrosomal Localization. [PDF]

J Clin Lab Anal
We demonstrate that OFIP is a novel substrate for UFMylation. UFL1‐mediated OFIP UFMylation is essential for its protein stability and centrosomal localization. ABSTRACT Background OFIP, also known as KIAA0753, is a centrosomal and pericentriolar satellite protein implicated in ciliogenesis, centriolar duplication, and microtubule stability. In humans,
Yang M, Zhao Z, Di J, Dong D, Li D, Ran J.   +5 more
europepmc   +2 more sources