Results 1 to 10 of about 40,574 (330)

Targeting of CRMP-2 to the primary cilium is modulated by GSK-3β. [PDF]

PLoS ONE, 2012
CRMP-2 plays a pivotal role in promoting axon formation, neurite outgrowth and elongation in neuronal cells. CRMP-2's role in other cells is unknown. Our preliminary results showed CRMP-2 expression in cilia of fibroblasts. To localize CRMP-2, define its
Young Ou, Ying Zhang, Min Cheng, Jerome B Rattner, Ina Dobrinski, Frans A van der Hoorn   +5 more
doaj   +3 more sources

Regulation of Primary Cilium Length by O-GlcNAc during Neuronal Development in a Human Neuron Model

Cells, 2023
The primary cilium plays critical roles in the homeostasis and development of neurons. Recent studies demonstrate that cilium length is regulated by the metabolic state of cells, as dictated by processes such as glucose flux and O-GlcNAcylation (OGN ...
Jie L. Tian, Chia-Wei Huang, Farzad Eslami, Michael Philip Mannino, Rebecca Lee Mai, Gerald W. Hart   +5 more
doaj   +1 more source

Strongly Truncated Dnaaf4 Plays a Conserved Role in Drosophila Ciliary Dynein Assembly as Part of an R2TP-Like Co-Chaperone Complex With Dnaaf6

Frontiers in Genetics, 2022
Axonemal dynein motors are large multi-subunit complexes that drive ciliary movement. Cytoplasmic assembly of these motor complexes involves several co-chaperones, some of which are related to the R2TP co-chaperone complex.
Jennifer Lennon, Petra zur Lage, Alex von Kriegsheim, Andrew P. Jarman   +3 more
doaj   +1 more source

Adenylate Cyclase Type III Is Not a Ubiquitous Marker for All Primary Cilia during Development. [PDF]

PLoS ONE, 2017
Adenylate cyclase type III (AC3) is localized in plasma membrane of neuronal primary cilium and can be used as a marker of this cilium. AC3 has also been detected in some other primary cilia such as those of fibroblasts, synoviocytes or astrocytes ...
Maria Cristina Antal, Karelle Bénardais, Brigitte Samama, Cyril Auger, Valérie Schini-Kerth, Said Ghandour, Nelly Boehm   +6 more
doaj   +1 more source

Spectrum of Genetic Variants in a Cohort of 37 Laterality Defect Cases

Frontiers in Genetics, 2022
Laterality defects are defined by the perturbed left–right arrangement of organs in the body, occurring in a syndromal or isolated fashion. In humans, primary ciliary dyskinesia (PCD) is a frequent underlying condition of defective left–right patterning,
Dinu Antony, Dinu Antony, Elif Gulec Yilmaz, Alper Gezdirici, Lennart Slagter, Zeineb Bakey, Zeineb Bakey, Helen Bornaun, Ibrahim Cansaran Tanidir, Tran Van Dinh, Han G. Brunner, Han G. Brunner, Peter Walentek, Peter Walentek, Sebastian J. Arnold, Sebastian J. Arnold, Rolf Backofen, Rolf Backofen, Miriam Schmidts, Miriam Schmidts, Miriam Schmidts   +20 more
doaj   +1 more source

A Proximity Mapping Journey into the Biology of the Mammalian Centrosome/Cilium Complex

Cells, 2020
The mammalian centrosome/cilium complex is composed of the centrosome, the primary cilium and the centriolar satellites, which together regulate cell polarity, signaling, proliferation and motility in cells and thereby development and homeostasis in ...
Melis Dilara Arslanhan, Dila Gulensoy, Elif Nur Firat-Karalar   +2 more
doaj   +1 more source

Dendritic cell proliferation by primary cilium in atopic dermatitis

Frontiers in Molecular Biosciences, 2023
Introduction: Atopic dermatitis (AD) is a common allergic eczema that affects up to 10% of adults in developed countries. Immune cells in the epidermis, namely, Langerhans cells (LCs), contribute to the pathogenesis of AD, although their exact role(s) in
Manami Toriyama, Manami Toriyama, Manami Toriyama, Defri Rizaldy, Defri Rizaldy, Defri Rizaldy, Motoki Nakamura, Motoki Nakamura, Yukiko Atsumi, Yukiko Atsumi, Michinori Toriyama, Fumitaka Fujita, Fumitaka Fujita, Fumitaka Fujita, Fumihiro Okada, Fumihiro Okada, Akimichi Morita, Hiroshi Itoh, Ken J. Ishii, Ken J. Ishii   +19 more
doaj   +1 more source

Forkhead transcription factor FKH-8 cooperates with RFX in the direct regulation of sensory cilia in Caenorhabditis elegans

eLife, 2023
Cilia, either motile or non-motile (a.k.a primary or sensory), are complex evolutionarily conserved eukaryotic structures composed of hundreds of proteins required for their assembly, structure and function that are collectively known as the ciliome ...
Rebeca Brocal-Ruiz, Ainara Esteve-Serrano, Carlos Mora-Martínez, Maria Luisa Franco-Rivadeneira, Peter Swoboda, Juan J Tena, Marçal Vilar, Nuria Flames   +7 more
doaj   +1 more source

Design and Implementation of a Composite Hydrophone of Sound Pressure and Sound Pressure Gradient

Micromachines, 2021
The bionic cilium MEMS vector hydrophone has the characteristics of low power consumption, small volume, and good low-frequency response. Nevertheless, there exists the problem of left–right ambiguity in the azimuth estimation of a single hydrophone.
Guojun Zhang, Lansheng Zhang, Songxiang Ji, Xi Yang, Renxin Wang, Wendong Zhang, Shie Yang   +6 more
doaj   +1 more source

Ciliary Dyneins and Dynein Related Ciliopathies

Cells, 2021
Although ubiquitously present, the relevance of cilia for vertebrate development and health has long been underrated. However, the aberration or dysfunction of ciliary structures or components results in a large heterogeneous group of disorders in ...
Dinu Antony, Han G. Brunner, Miriam Schmidts   +2 more
doaj   +1 more source