Results 31 to 40 of about 40,574 (330)
Smoothened adopts multiple active and inactive conformations capable of trafficking to the primary cilium. [PDF]
, 2009 Activation of Hedgehog (Hh) signaling requires the transmembrane protein Smoothened (Smo), a member of the G-protein coupled receptor superfamily. In mammals, Smo translocates to the primary cilium upon binding of Hh ligands to their receptor, Patched ...
Chen, Miao-Hsueh +2 more
core +3 more sources
A recombinant BBSome core complex and how it interacts with ciliary cargo
eLife, 2017 Cilia are small, antenna-like structures on the surface of eukaryotic cells that harbor a unique set of sensory proteins, including GPCRs and other membrane proteins.
Björn Udo Klink +5 more
doaj +1 more source
Frontiers in Genetics, 2022 Lung adenocarcinoma (LUAD) has become the most prevalent histologic subset of primary lung cancer, and effective innovative prognostic models are needed to enhance the feasibility of targeted therapies for the disease.
Huizhe Zhang +7 more
doaj +1 more source
Assembling a primary cilium [PDF]
Current Opinion in Cell Biology, 2013 Cilia are evolutionarily conserved, membrane-bound, microtubular projections emanating from the cell surface. They are assembled on virtually all cell types in the human body, with very few exceptions, and several recent reviews have covered the topic in great detail.
Brian David Dynlacht, Sehyun Kim
openaire +2 more sources
Shortened primary cilium length and dysregulated Sonic hedgehog signaling in Niemann-Pick C1 disease [PDF]
, 2017 The Niemann-Pick type C1 (NPC1) disease is a neurodegenerative lysosomal storage disorder due to mutations in the NPC1 gene, encoding a transmembrane protein related to the Sonic hedgehog receptor, Patched, and involved in intracellular trafficking of ...
Canterini, Sonia +7 more
core +1 more source
Mixing and transport by ciliary carpets: a numerical study [PDF]
, 2013 We use a 3D computational model to study the fluid transport and mixing due to the beating of an infinite array of cilia. In accord with recent experiments, we observe two distinct regions: a fluid transport region above the cilia and a fluid mixing ...
Ding, Yang +3 more
core +3 more sources
, 2023 Spodoptera cilium (GUENÉE, 1852) M a t e r i a l u n t e r s u c h t: Brava, Nova Sintra, Santana, 490 m, 08.12.2004, 1 ex., det. Behounek. V e r b r e i t u n g: Afrika,ArabischeHalbinsel,Südeuropa,Südostasien.
Aistleitner, Eyjolf +2 more
openaire +1 more source
The photoreceptor cilium and its diseases [PDF]
Current Opinion in Genetics & Development, 2019 Light sensation occurs in photoreceptor outer segments (OS), which derive from highly specialized primary cilia, based on structural and molecular similarities. Ciliary dysfunction causes ciliopathies, in which retinal degeneration is common. The connecting cilium (CC) is the obligate passage for proteins moving between ciliary and cellular compartment,
Bachmann-Gagescu, Ruxandra +1 more
openaire +2 more sources
Autophagy and the primary cilium in cell metabolism: What’s upstream?
Frontiers in Cell and Developmental Biology, 2022 The maintenance of cellular homeostasis in response to extracellular stimuli, i.e., nutrient and hormone signaling, hypoxia, or mechanical forces by autophagy, is vital for the health of various tissues.
Aurore Claude-Taupin +2 more
doaj +1 more source
The Cilium Secretes Bioactive Ectosomes [PDF]
Current Biology, 2013 The release of membrane vesicles from the surface of cells into their surrounding environment is now recognized as an important pathway for the delivery of proteins to extracellular sites of biological function. Membrane vesicles of this kind, termed exosomes and ectosomes, are the result of active processes and have been shown to carry a wide array of
Joel L. Rosenbaum +3 more
openaire +3 more sources