Results 31 to 40 of about 34,354 (355)

The primary cilium dampens proliferative signaling and represses a G2/M transcriptional network in quiescent myoblasts

BMC Molecular and Cell Biology, 2020
Background Reversible cell cycle arrest (quiescence/G0) is characteristic of adult stem cells and is actively controlled at multiple levels. Quiescent cells also extend a primary cilium, which functions as a signaling hub.
Nisha Venugopal, Ananga Ghosh, Hardik Gala, Ajoy Aloysius, Neha Vyas, Jyotsna Dhawan   +5 more
doaj   +1 more source

The IDA3 adapter, required for intraflagellar transport of I1 dynein, is regulated by ciliary length [PDF]

, 2018
Axonemal dyneins, including inner dynein arm I1, assemble in the cytoplasm prior to transport into cilia by intraflagellar transport (IFT). How I1 dynein interacts with IFT is not understood.
Alford, Lea M, Dutcher, Susan K, Fu, Gang, Gokhale, Avanti, Hunter, Emily L, Hwang, Juyeon, Kamiya, Ritsu, Lechtreck, Karl, Lewis, Brian, Lin, Huawen, Nicastro, Daniela, Sale, Winfield S, Wirschell, Maureen, Yamamoto, Ryosuke, Yang, Fan   +14 more
core   +2 more sources

A Cilium Is Not a Cilium Is Not a Cilium: Signaling Contributes to Ciliary Morphological Diversity [PDF]

Developmental Cell, 2008
Mukhopadhyay and colleagues reveal in this issue of Developmental Cell that signaling mediated by a specialized neuronal cilium in C. elegans affects its structure. The finding that this cilium is modified in response to the cues it transduces suggests that cilia may not be static antennae, but organelles whose functions are shaped by their signaling ...
openaire   +3 more sources

Assembling a primary cilium [PDF]

Current Opinion in Cell Biology, 2013
Cilia are evolutionarily conserved, membrane-bound, microtubular projections emanating from the cell surface. They are assembled on virtually all cell types in the human body, with very few exceptions, and several recent reviews have covered the topic in great detail.
Brian David Dynlacht, Sehyun Kim
openaire   +2 more sources

Forkhead transcription factor FKH-8 cooperates with RFX in the direct regulation of sensory cilia in Caenorhabditis elegans

eLife, 2023
Cilia, either motile or non-motile (a.k.a primary or sensory), are complex evolutionarily conserved eukaryotic structures composed of hundreds of proteins required for their assembly, structure and function that are collectively known as the ciliome ...
Rebeca Brocal-Ruiz, Ainara Esteve-Serrano, Carlos Mora-Martínez, Maria Luisa Franco-Rivadeneira, Peter Swoboda, Juan J Tena, Marçal Vilar, Nuria Flames   +7 more
doaj   +1 more source

Gli2a protein localization reveals a role for Iguana/DZIP1 in primary ciliogenesis and a dependence of Hedgehog signal transduction on primary cilia in the zebrafish [PDF]

, 2010
Background: In mammalian cells, the integrity of the primary cilium is critical for proper regulation of the Hedgehog (Hh) signal transduction pathway.
Ingham, P.W., Kim, H.R., Richardson, J., van Eeden, F.   +3 more
core   +3 more sources

A novel defined cuproptosis-related gene signature for predicting the prognosis of lung adenocarcinoma

Frontiers in Genetics, 2022
Lung adenocarcinoma (LUAD) has become the most prevalent histologic subset of primary lung cancer, and effective innovative prognostic models are needed to enhance the feasibility of targeted therapies for the disease.
Huizhe Zhang, Yanchen Shi, Qing Yi, Cong Wang, Qingqing Xia, Yufeng Zhang, Weilong Jiang, Jia Qi   +7 more
doaj   +1 more source

Discrete cilia modelling with singularity distributions [PDF]

, 2007
We discuss in detail techniques for modelling flows due to finite and infinite arrays of beating cilia. An efficient technique, based on concepts from previous ‘singularity models’ is described, that is accurate in both near and far-fields.
A.-K. Tornberg, A.T. Chwang, B.A.A. Orme, C.J. Brokaw, C.J. Tabin, D. J. Smith, E. A. Gaffney, E. Bartha, E. Bartha, E. Lauga, E.O. Tuck, F.A. Meyer, G.J. Hancock, G.K. Batchelor, G.R. Fulford, G.R. Fulford, G.R. Fulford, H. Hagiwara, H. Matsui, H. Matsui, J. McGrath, J. R. Blake, J.H.E. Cartwright, J.J.L. Higdon, J.M. Burgers, J.P.K. Tillett, J.R. Blake, J.R. Blake, J.R. Blake, J.R. Blake, J.R. Blake, K. Kosaki, L. Fauci, M. Eisenbach, M. Salathe, M.E. Staben, M.J. Lighthill, M.J. Sanderson, N. Liron, N. Liron, N. Liron, N. Liron, N. Liron, N. Phan-Thien, N.A. Brown, P. Talbot, R. Tarran, R.C. Boucher, R.E. Johnson, R.G. Cox, R.J. Clarke, S. Childress, S. Gueron, S. Gueron, S. Gueron, S. Nonaka, S. Nonaka, S. Nonaka, W.E. Williams, X.Z. Tang, Y. Okada   +60 more
core   +1 more source

A recombinant BBSome core complex and how it interacts with ciliary cargo

eLife, 2017
Cilia are small, antenna-like structures on the surface of eukaryotic cells that harbor a unique set of sensory proteins, including GPCRs and other membrane proteins.
Björn Udo Klink, Eldar Zent, Puneet Juneja, Anne Kuhlee, Stefan Raunser, Alfred Wittinghofer   +5 more
doaj   +1 more source

The primary cilium influences interleukin-1 beta-induced NF kappa B signalling by regulating IKK activity [PDF]

, 2014
The primary cilium is an organelle acting as a master regulator of cellular signalling. We have previously shown that disruption of primary cilia assembly, through targeting intraflagellar transport, is associated with muted nitric oxide and ...
A.K.T. Wann, Acunzo, Alford, Amin, Amin, Baeuerle, Baeuerle, Baeuerle, Besschetnova, Boehm, Bracken, Cheong, Clement, Corbit, Corbit, Crepieux, Crowe, DiDonato, Dodd, Dossumbekova, Gao, Gerdes, Griscavage, Hatakeyama, Haycraft, Hoffmann, Huber, J.P. Chapple, Jones, Jones, Kammanadiminti, Karsdal, Lambrecht, Lancaster, Lattke, M.M. Knight, Martel-Pelletier, McGlashan, McMurray, Nauli, Oeckinghaus, Parcellier, Park, Pearle, Plummer, Rohatgi, Saklatvala, Saklatvala, Schmidts, Schneider, Shim, Shiota, Simons, Smith, Takaki, Taulman, Tazawa, Tran, Vezina, Wann, Wann, Wann, Werner, Whitfield, Williams, Windheim, Wu, Zhao, Zhu   +68 more
core   +1 more source