Results 41 to 50 of about 40,574 (330)

Dissecting the Vesicular Trafficking Function of IFT Subunits

Frontiers in Cell and Developmental Biology, 2020
Intraflagellar transport (IFT) was initially identified as a transport machine with multiple protein subunits, and it is essential for the assembly, disassembly, and maintenance of cilium/flagellum, which serves as the nexus of extracellular-to ...
Huihui Yang, Huihui Yang, Kaiyao Huang
doaj   +1 more source

Primary cilium: a paradigm for integrating mathematical modeling with experiments and numerical simulations in mechanobiology

Mathematical Biosciences and Engineering, 2021
Primary cilia are non-motile, solitary (one per cell) microtubule-based organelles that emerge from the mother centriole after cells have exited the mitotic cycle.
Zhangli Peng, Andrew Resnick, Y.-N. Young   +2 more
doaj   +1 more source

Probing cilia-driven flow in living embryos using femtosecond laser ablation and fast imaging [PDF]

, 2009
Embryonic development strictly depends on fluid dynamics. As a consequence, understanding biological fluid dynamic is essential since it is unclear how flow affects development.
Fraser, Scott E., Supatto, Willy, Vermot, Julien   +2 more
core   +1 more source

The dynamic cilium in human diseases [PDF]

PathoGenetics, 2009
Cilia are specialized organelles protruding from the cell surface of almost all mammalian cells. They consist of a basal body, composed of two centrioles, and a protruding body, named the axoneme. Although the basic structure of all cilia is the same, numerous differences emerge in different cell types, suggesting diverse functions.
A. D’Angelo, FRANCO, BRUNELLA
openaire   +3 more sources

In-phase and anti-phase flagellar synchronization by waveform compliance and basal coupling

New Journal of Physics, 2017
We present a theory of flagellar synchronization in the green alga Chlamydomonas , using full treatment of flagellar hydrodynamics and measured beat patterns.
Gary S Klindt, Christian Ruloff, Christian Wagner, Benjamin M Friedrich   +3 more
doaj   +1 more source

PDE6δ-mediated sorting of INPP5E into the cilium is determined by cargo-carrier affinity [PDF]

, 2016
The phosphodiesterase 6 delta subunit (PDE6δ) shuttles several farnesylated cargos between membranes. The cargo sorting mechanism between cilia and other compartments is not understood.
Fansa, Eyad Kalawy, Ismail, Shehab, Kösling, Stefanie Kristine, Wittinghofer, Alfred, Zent, Eldar   +4 more
core   +1 more source

Atrioventricular canal defect and genetic syndromes: the unifying role of sonic hedgehog [PDF]

, 2019
The atrioventricular canal defect (AVCD) is a congenital heart defect (CHD) frequently associated with extracardiac anomalies (75%). Previous observations from a personal series of patients with AVCD and "polydactyly syndromes" showed that the distinct ...
Baban, A, Calcagni, G, Dallapiccola, B, De Luca, A, Dentici, M L, Digilio, M C, Marino, B, Pugnaloni, F, Tartaglia, M, Versacci, P   +9 more
core   +1 more source

The Drosophila orthologue of the primary ciliary dyskinesia-associated gene, DNAAF3, is required for axonemal dynein assembly

Biology Open, 2021
Ciliary motility is powered by a suite of highly conserved axoneme-specific dynein motor complexes. In humans, the impairment of these motors through mutation results in the disease primary ciliary dyskinesia (PCD).
Petra zur Lage, Zhiyan Xi, Jennifer Lennon, Iain Hunter, Wai Kit Chan, Alfonso Bolado Carrancio, Alex von Kriegsheim, Andrew P. Jarman   +7 more
doaj   +1 more source

Primary cilia elongation in response to interleukin-1 mediates the inflammatory response [PDF]

, 2012
Primary cilia are singular, cytoskeletal organelles present in the majority of mammalian cell types where they function as coordinating centres for mechanotransduction, Wnt and hedgehog signalling. The length of the primary cilium is proposed to modulate
A. K. T. Wann, AC Lin, AJ Espanol, AM Malone, BD Engel, BK Yoder, CA Dinarello, CG Jensen, CM Asleson, D Qian, DA Lee, E Verghese, E Verghese, EJ Michaud, EM Mokrzan, GJ Pazour, H Tukachinsky, I Memon, J Kim, JA Deane, JL Rosenbaum, JM Neugebauer, K Gardner, KJ Palmer, L Schneider, M Barzi, M Cao, M. M. Knight, MA Lancaster, MB Hovater, N Sharma, P Tummala, PA Lefebvre, PV Tran, RY Kwon, S Abdul-Majeed, S Agarwal, S Kim, S Massinen, S Mukhopadhyay, S Pritchard, S Toffoli, SC Goetz, SM Nauli, SR McGlashan, SR McGlashan, SR McGlashan, TT Chowdhury, TY Besschetnova, Y Chen, Y Ou, YH Choi   +51 more
core   +2 more sources

Predicting the locations of force-generating dyneins in beating cilia and flagella

Frontiers in Cell and Developmental Biology, 2022
Cilia and flagella are slender cylindrical organelles whose bending waves propel cells through fluids and drive fluids across epithelia. The bending waves are generated by dynein motor proteins, ATPases whose force-generating activity changes over time ...
Jonathon Howard, Jonathon Howard, Jonathon Howard, Jonathon Howard, Alexander Chasteen, Xiaoyi Ouyang, Veikko F. Geyer, Pablo Sartori   +7 more
doaj   +1 more source