Results 41 to 50 of about 34,354 (355)
eLife, 2015 Small G-proteins of the ADP-ribosylation-factor-like (Arl) subfamily have been shown to be crucial to ciliogenesis and cilia maintenance. Active Arl3 is involved in targeting and releasing lipidated cargo proteins from their carriers PDE6δ and UNC119a/b ...
Katja Gotthardt +5 more
doaj +1 more source
Design and Fabrication of an Integrated Hollow Concave Cilium MEMS Cardiac Sound Sensor
Micromachines, 2022 In light of a need for low-frequency, high sensitivity and broadband cardiac murmur signal detection, the present work puts forward an integrated MEMS-based heart sound sensor with a hollow concave ciliary micro-structure. The advantages of a hollow MEMS
Bo Wang +9 more
doaj +1 more source
Asymmetric motion of magnetically actuated artificial cilia [PDF]
Lab Chip, 2017,17, 3138-3145, 2018 Most microorganisms use hair-like cilia with asymmetric beating to perform vital bio-physical processes. In this paper, we demonstrate a novel fabrication method for creating magnetic artificial cilia capable of such biologically inspired asymmetrical beating pattern essential for creating microfluidic transport in low Reynolds number.
arxiv +1 more source
Smoothened adopts multiple active and inactive conformations capable of trafficking to the primary cilium. [PDF]
, 2009 Activation of Hedgehog (Hh) signaling requires the transmembrane protein Smoothened (Smo), a member of the G-protein coupled receptor superfamily. In mammals, Smo translocates to the primary cilium upon binding of Hh ligands to their receptor, Patched ...
Chen, Miao-Hsueh +2 more
core +3 more sources
Design and Implementation of a Composite Hydrophone of Sound Pressure and Sound Pressure Gradient
Micromachines, 2021 The bionic cilium MEMS vector hydrophone has the characteristics of low power consumption, small volume, and good low-frequency response. Nevertheless, there exists the problem of left–right ambiguity in the azimuth estimation of a single hydrophone.
Guojun Zhang +6 more
doaj +1 more source
Ciliary Dyneins and Dynein Related Ciliopathies
Cells, 2021 Although ubiquitously present, the relevance of cilia for vertebrate development and health has long been underrated. However, the aberration or dysfunction of ciliary structures or components results in a large heterogeneous group of disorders in ...
Dinu Antony +2 more
doaj +1 more source
Fluid mechanics of nodal flow due to embryonic primary cilia [PDF]
, 2008 Breaking of left–right symmetry is crucial in vertebrate development. The role of cilia-driven flow has been the subject of many recent publications, but the underlying mechanisms remain controversial.
Blake, J R, Gaffney, E. A., Smith, D J
core +2 more sources
The photoreceptor cilium and its diseases [PDF]
Current Opinion in Genetics & Development, 2019 Light sensation occurs in photoreceptor outer segments (OS), which derive from highly specialized primary cilia, based on structural and molecular similarities. Ciliary dysfunction causes ciliopathies, in which retinal degeneration is common. The connecting cilium (CC) is the obligate passage for proteins moving between ciliary and cellular compartment,
Bachmann-Gagescu, Ruxandra +1 more
openaire +2 more sources
The Cilium Secretes Bioactive Ectosomes [PDF]
Current Biology, 2013 The release of membrane vesicles from the surface of cells into their surrounding environment is now recognized as an important pathway for the delivery of proteins to extracellular sites of biological function. Membrane vesicles of this kind, termed exosomes and ectosomes, are the result of active processes and have been shown to carry a wide array of
Joel L. Rosenbaum +3 more
openaire +3 more sources
The Primary Cilium and Neuronal Migration
Cells, 2022 The primary cilium (PC) is a microtubule-based tiny sensory organelle emanating from the centrosome and protruding from the surface of most eukaryotic cells, including neurons. The extremely severe phenotypes of ciliopathies have suggested their paramount importance for multiple developmental events, including brain formation.
Julie Stoufflet, Isabelle Caillé
openaire +3 more sources