Results 111 to 120 of about 336,986 (421)
New Perspectives on Semiconducting Conjugated Oligomers for Neuromodulation in Hydra vulgaris
Advanced Materials Interfaces, EarlyView.Semiconducting organic compounds, thiophene‐based, modify the rhythmic electrical activity of the cnidarian Hydra vulgaris acting on specific neuronal circuits. The ETE‐S trimer also forms electronically conducting wires in the living tissues of the animal.
Giuseppina Tommasini +7 more
wiley +1 more source
An antagonistic role of clock genes and lima1 in kidney regeneration
Communications BiologyThe circadian clock genes are known important for kidney development, maturation and physiological functions. However, whether and how they play a role in renal regeneration remain elusive.
Xian He +4 more
doaj +1 more source
Molecular Targets for Small-Molecule Modulators of Circadian Clocks.
Current drug metabolism, 2016 BACKGROUND Circadian clocks are endogenous timing systems that regulate various aspects of mammalian metabolism, physiology and behavior. Traditional chronotherapy refers to the administration of drugs in a defined circadian time window to achieve ...
Baokun He, Zheng Chen
semanticscholar +1 more source
The Circadian Clocks of Mice and Men [PDF]
Neuron, 2001 Major strides have been made toward understanding the molecular mechanism of rodent clocks. But how far do those steps carry us toward understanding circadian clock function in humans? Practical advances in human genetics, not the least of which is the availability of a virtually complete genome sequence, now allow animal research to be complemented by
Chang, Dennis C., Reppert, Steven M.
openaire +4 more sources
Epileptiform Activity and Seizure Risk Follow Long‐Term Non‐Linear Attractor Dynamics
Advanced Science, EarlyView.This study leverages the HAVOK framework to model long‐term, nonlinear attractor dynamics underlying epileptiform activity and seizure risk in epilepsy patients. By identifying key forcing mechanisms driving chaotic transitions, the findings improve seizure risk forecasting over multi‐day cycles and provide a pathway for personalized, data‐driven ...
Richard E Rosch +4 more
wiley +1 more source
Cell Reports, 2020 Summary: Circadian clocks are endogenous oscillators that generate cell-autonomous rhythms that govern cellular processes and are synchronized by external cues in the local macro- and micro-environments.
Suihong Huang +5 more
doaj
Circadian clock disruption promotes the degeneration of dopaminergic neurons in male Drosophila
Nature Communications, 2023 Sleep and circadian rhythm disruptions are frequent comorbidities of Parkinson’s disease (PD), a disorder characterized by the progressive loss of dopaminergic (DA) neurons in the substantia nigra.
Michaëla Majcin Dorcikova +3 more
doaj +1 more source
Discrete gene replication events drive coupling between the cell cycle and circadian clocks [PDF]
, 2015 Many organisms possess both a cell cycle to control DNA replication and a circadian clock to anticipate changes between day and night. In some cases, these two rhythmic systems are known to be coupled by specific, cross-regulatory interactions. Here, we use mathematical modeling to show that, additionally, the cell cycle generically influences ...
arxiv +1 more source
Robust circadian clocks from coupled protein modification and transcription-translation cycles [PDF]
P Natl Acad Sci Usa (2010) vol. 107 (52) pp. 22540-5, 2010 The cyanobacterium Synechococcus elongatus uses both a protein phosphorylation cycle and a transcription-translation cycle to generate circadian rhythms that are highly robust against biochemical noise. We use stochastic simulations to analyze how these cycles interact to generate stable rhythms in growing, dividing cells.
arxiv +1 more source
MicroRNA-433 Dampens Glucocorticoid Receptor Signaling, Impacting Circadian Rhythm and Osteoblastic Gene Expression [PDF]
, 2016 FUNDING This work was supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health [AR44877]; the National Institutes for Dental and Craniofacial Research [5T90DE21989]; a Grant-in-Aid award ...
Delany, Anne M +4 more
core +1 more source