Results 171 to 180 of about 52,173 (326)

Writing a wrong: Coupled RNA polymerase II transcription and RNA quality control [PDF]

, 2019
Processing and maturation of precursor RNA species is coupled to RNA polymerase II transcription. Co-transcriptional RNA processing helps to ensure efficient and proper capping, splicing, and 3' end processing of different RNA species to help ensure ...
Hughes, Katlyn D., Mosley, Amber L., Peck, Sarah A., Victorino, Jose F.   +3 more
core   +1 more source

Novel Liquid Biopsy in Gastrointestinal Cancers

Journal of Gastroenterology and Hepatology, EarlyView.
ABSTRACT Gastrointestinal (GI) cancers represent a significant global health burden, being among the leading causes of cancer‐related deaths. The prognosis for patients remains unsatisfactory, largely because most cancers are detected at advanced stages.
Li‐Chun Chang, Tang‐Long Shen, Takahiro Ochiya   +2 more
wiley   +1 more source

A ceRNA approach may unveil unexpected contributors to deletion syndromes, the model of 5q- syndrome [PDF]

, 2015
In genomic deletions, gene haploinsufficiency might directly configure a specific disease phenotype. Nevertheless, in some cases no functional association can be identified between haploinsufficient genes and the deletion-associated phenotype ...
Arancio, W., Bongiovanni, L., Genovese, S., Tripodo, C.   +3 more
core   +2 more sources

Additional file 15 of CircRNAs in Xiang pig ovaries among diestrus and estrus stages

, 2022
Xi Niu, Yali Huang, Huan Lu, Sheng Li, Shihui Huang, Xueqin Ran, Jiafu Wang   +6 more
openalex   +1 more source

Circular RNA Vv‐circCOR27 modulates thermotolerance through attenuating VvHSP90.2b‐VvHsfA7a interaction in grapevine

New Phytologist, EarlyView.
Summary Circular RNAs (circRNAs) are single‐stranded, covalently closed RNA molecules that arise from exon back‐splicing. The identification and function investigation of circRNAs have been comprehensively explored in plants, however, the regulatory mechanisms are largely unknown.
Yi Ren, Yuanyuan Xu, Moyang Liu, Lipeng Zhang, Yue Song, Junpeng Li, Jingjing Liu, Dongying Fan, Zhen Zhang, Juan He, Jiuyun Wu, Qian Zha, Zhen Gao, Zheng'an Yang, Chao Ma   +14 more
wiley   +1 more source

Bioinformatics evaluation of the circRNA–miRNA–mRNA axis in cervical squamous cell carcinoma

Exploration of Medicine
Aim: Cervical squamous cell carcinoma (CESC) is a highly prevalent women’s gynecologic disease. Because the specific mechanisms associated with the illness are still mostly unclear, more investigation is needed to comprehend the triggers of CESC’s ...
Murat KAYA
doaj   +1 more source

Large-scale benchmarking of circRNA detection tools reveals large differences in sensitivity but not in precision

bioRxiv, 2023
Marieke Vromman, J. Anckaert, S. Bortoluzzi, Alessia Buratin, Chia-Ying Chen, Qinjie Chu, Trees-Juen Chuang, Roozbeh Dehghannasiri, C. Dieterich, Xin Dong, P. Flicek, Enrico Gaffo, W. Gu, Chunjiang He, Steve Hoffmann, Osagie G. Izuogu, M. Jackson, Tobias Jakobi, E. Lai, J. Nuytens, J. Salzman, M. Santibanez-Koref, P. Stadler, O. Thas, E. V. Eynde, K. Verniers, Guoxia Wen, J. Westholm, Li Yang, Chuyu Ye, N. Yigit, Guoliang Yuan, Jinyang Zhang, F. Zhao, J. Vandesompele, P. Volders   +35 more
semanticscholar   +1 more source

Functional variant of the carboxypeptidase M (CPM) gene may affect silica-related pneumoconiosis susceptibility by its expression: a multistage case-control study. [PDF]

, 2019
ObjectivesIn a genome-wide association study, we discovered chromosome 12q15 (defined as rs73329476) as a silica-related pneumoconiosis susceptibility region. However, the causal variants in this region have not yet been reported.MethodsWe systematically
Chu, Minjie, Gao, Yuexia, Huang, Qiqing, Lian, Yulong, Lu, Yihua, Sang, Lingli, Tian, Tian, Wang, Wei, Wu, Jianqing, Wu, Shuangshuang, Xiao, Jing, Yi, Min, Yu, Yuhui, Yuan, Weiwei, Zhang, Mingjiong, Zhang, Zuo-Feng, Zhuang, Xun   +16 more
core  

The circRNA–microRNA code: emerging implications for cancer diagnosis and treatment

Molecular Oncology, 2019
Circular RNAs (circRNAs) comprise an emerging new class of endogenous RNAs expressed abundantly by the eukaryotic transcriptome. They are characterized by a covalently closed loop structure, resulting in RNA molecules that are more stable than linear ...
L. Verduci, S. Strano, Y. Yarden, G. Blandino   +3 more
semanticscholar   +1 more source

RNA‐Based Therapies for Inherited Metabolic Disorders

Journal of Inherited Metabolic Disease, Volume 49, Issue 2, March 2026.
ABSTRACT Inherited metabolic disorders (IMDs) are a diverse and complex group of genetic conditions resulting from deficiencies in enzymes, transporters, or cofactors. These deficiencies lead to metabolic dysfunction and severe clinical consequences. Despite significant progress in understanding their molecular basis, treatment options remain limited ...
Reddy Sreekanth Vootukuri, Sonam Gurung, Roopkatha Ghosh, Philippa B. Mills, Julien Baruteau, Haiyan Zhou   +5 more
wiley   +1 more source