Results 171 to 180 of about 45,661 (289)
Cancer Science, EarlyView.circNEK11 is overexpressed in human HCC tissues, especially in recurrent tissues, and promotes the oncogenic functions of HCC cells. circNEK11 interacted with miR‐1236‐3p to stimulate GPX2 expression. Our findings highlight the potential of circNEK11 as a biomarker for HCC diagnosis and suggest that targeting circNEK11 may be an effective strategy for ...
Qian Li +10 more
wiley +1 more source
Signal and noise in circRNA translation
Methods, 2020 AbstractWithin recent years, circular RNAs (circRNAs) have been an attractive new field of research in RNA biology and disease. Consequently, numerous studies have been published towards the disclosure of circRNA biogenesis and function. Initially, circRNAs were described as a subclass of cytoplasmic non-coding RNA, however, a few recent observations ...
openaire +5 more sources
Transcriptome regulation network in Multiple sclerosis: Role of circular RNAs. [PDF]
, 2021 274 p.Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system, that leads to neurological disability. The disease course and clinical phenotype are highly variable and therefore, biomarkers that can aid in the clinical ...
Iparraguirre Gil, Leire
core
Cell Proliferation, EarlyView.Non‐coding RNAs (ncRNAs) regulate breast cancer radioresistance via cell cycle, DNA repair and tumour microenvironment pathways. Targeting ncRNAs (e.g., HOTAIR and miR‐155) with RNA‐based therapies (ASOs and CRISPR) shows promise but faces delivery challenges.
Xiaohui Zhao +8 more
wiley +1 more source
The Roles of CircRNAs in Mitochondria
Journal of CancerMitochondria participate in varieties of cellular events. It is widely accepted that human mitochondrial genome encodes 13 proteins, 2 rRNAs, and 22 tRNAs. Gene variation derived from human nuclear genome cannot completely explain mitochondrial diseases.
Liu, Donghong +3 more
openaire +2 more sources
Functional variant of the carboxypeptidase M (CPM) gene may affect silica-related pneumoconiosis susceptibility by its expression: a multistage case-control study. [PDF]
, 2019 ObjectivesIn a genome-wide association study, we discovered chromosome 12q15 (defined as rs73329476) as a silica-related pneumoconiosis susceptibility region. However, the causal variants in this region have not yet been reported.MethodsWe systematically
Chu, Minjie +16 more
core
Circular RNAs and Its Biological Functions in Health and Disease [PDF]
, 2019 Circular RNAs (circRNAs) belong to the family of long noncoding RNAs (lncRNA) that, unlike linear RNAs, are characterized by a covalently closed circular RNA structure lacking 5′ cap and 3′ poly-adenylated tails.
Alp, Ebru +2 more
core +1 more source
Journal of Cardiovascular Electrophysiology, EarlyView.ABSTRACT This state‐of‐the‐art review is based on the Philippe Coumel Lecture in 2024 (Figure 1). It highlights the confluence of two major cardiovascular epidemics, atrial fibrillation and heart failure, with preserved ejection fraction. In these conditions, advances in electrophysiology and heart failure physiology are intertwined and are integrated ...
Sanjeev Saksena +3 more
wiley +1 more source
Journal of Phycology, EarlyView.Abstract Mitochondrial mRNAs in the green algal class Chlorophyceae have non‐template 3' oligo‐cytosine‐rich additions, also known as oligo(C), polycitydylation, or poly(C) “tails.” These oligonucleotide additions are believed to be unique to green algal mitochondria, as none have been observed in any other organism.
A. Bruce Cahoon +2 more
wiley +1 more source
International Journal of NanomedicineRui Han,1,2 Xiwu Rao,3 Huiling Zhou,4 Lingeng Lu5– 7 1Department of Chinese Medicine Oncology, The First Affiliated Hospital of Naval Medical University, Shanghai, People’s Republic of China; 2Department of Chinese Medicine, Naval Medical University ...
Han R, Rao X, Zhou H, Lu L
doaj