Results 161 to 170 of about 34,260 (269)
Glia, Volume 74, Issue 5, May 2026.ZSWIM8, an E3 ubiquitin ligase that broadly targets IDR‐rich proteins, drives MiR‐7‐dependent AGO2 degradation and the turnover of many RBPs. Loss of ZSWIM8 leads to MiR‐7 accumulation in oligodendrocyte progenitor cells and myelination defects in the developing brain. ABSTRACT Proteostasis of proteins with intrinsically disordered regions (IDRs) is of
Jing Lei +13 more
wiley +1 more source
Study on the Roles of Long Noncoding RNA HCAL in Hepatocellular Carcinoma [PDF]
, 2016 【背景】 原发性肝癌是最常见的恶性肿瘤之一，是我国发病率和死亡率均排名第二的恶性肿瘤。原发性肝癌中，大部分为肝细胞肝癌（简称肝癌）。虽然肝癌的诊断及手术切除、放化疗等治疗手段取得了很大的进步，但肝癌患者总体的生存率仍不理想。近年来，对肝癌的分子生物学机制进行了多方面的研究，并证实肝癌的发生发展伴随着一系列分子表达的失调及信号通路的异常。因此，从分子水平深入探讨肝癌发生发展及转移的机制，对寻找早期诊断、预测预后的生物标志物和治疗的分子靶点具有重要的临床意义。 长链非编码RNA ...
谢程融
core
In vivo CAR therapies: Turning the patient into their own CAR factory
HemaSphere, Volume 10, Issue 5, May 2026.Abstract Over the past decade, ex vivo autologous chimeric antigen receptor (CAR)‐T‐cell therapies have reshaped the treatment of B‐cell malignancies. Despite their remarkable clinical efficacy, their application remains limited by complex manufacturing processes, demanding logistics, long turnaround times, and substantial costs. In vivo CAR approaches
François Vilcot +3 more
wiley +1 more source
The lariat-derived circRNA from ATXN2L: an outstanding circRNA in pigs
, 2021 In contrast to exon-derived circular RNAs (exonic circRNAs), which are widely studied, much less in known on intron-derived circRNAs: when intron lariats escape degradation due to debranching failure they can become circRNA precursors. When characterizing the intronic circRNA landscape of porcine and bovine testis, liver and muscle, only a circRNA ...
Robic, Annie +4 more
openaire +1 more source
Immunity, Inflammation and Disease, Volume 14, Issue 5, May 2026.ABSTRACT Background Sjögren's syndrome (SS) is a chronic, systemic inflammatory disorder primarily characterized by dry eyes and dry mouth, often involving multiple organ systems. The disease's heterogeneous clinical presentation and the absence of non‐invasive, specific biomarkers complicate its diagnosis and prognostic assessment.
Xinyan Zhang +4 more
wiley +1 more source
CircRNA-mediated regulation of cardiovascular disease
Frontiers in Cardiovascular MedicineCardiovascular diseases (CVDs) encompass a range of disorders affecting the heart and blood vessels, such as coronary heart disease, cerebrovascular disease (e.g., stroke), peripheral arterial disease, congenital heart anomalies, deep vein thrombosis, and pulmonary embolism. CVDs are often referred to as the leading cause of mortality worldwide. Recent
Ke-yun Cheng +8 more
openaire +3 more sources
RNA Modifications: Current Understandings and Future Perspectives
MedComm, Volume 7, Issue 5, May 2026.Types of RNA modification. We have summarized the currently common types of RNA modifications, including ac4C, m6A, m1A, m5C, m3C, m7G, and ψ, and visually characterized their features through structural formulas. The characteristic structures are marked with a background color different from the background color.
Shiyu Xiao +7 more
wiley +1 more source
Journal of Diabetes, Volume 18, Issue 5, May 2026.This review highlights mitochondrial dysfunction as a central driver of pancreatic β cell failure in diabetes, caused by disrupted mitochondrial quality control (MQC), oxidative stress, and impaired organelle communication. Emerging therapies, such as DRAK2 inhibitors and metabolic reprogramming agents, show promise in restoring β cell function by ...
Ruihan Li +5 more
wiley +1 more source
Clinical and functional significance of circular RNAs in cytogenetically normal AML [PDF]
, 2020 al., et +2 more
core +1 more source