Cancer Science, Volume 117, Issue 5, Page 1362-1379, May 2026.Our findings identify circ‐0030167/IGF2BP1/HMOX1 axis as a critical regulatory factor targeting mitochondria‐mediated ferroptosis, thereby presenting a novel therapeutic target for PC combination therapies. ABSTRACT Pancreatic cancer (PC) represents a highly aggressive malignancy characterized by a 5 year survival rate of less than 12%.
Qun Zhao +6 more
wiley +1 more source
Cancer Science, Volume 117, Issue 5, Page 1322-1332, May 2026.We performed the first transcriptome‐wide profiling of m5C modifications in osteosarcoma, analyzing four pairs of tumor and adjacent normal tissues. We revealed that NSUN2 suppresses apoptosis in osteosarcoma cells by promoting GPRC5B m5C modification and expression.
Zhenyi Chen +10 more
wiley +1 more source
Journal of Cellular and Molecular Medicine, Volume 30, Issue 9, May 2026.ABSTRACT Gastrointestinal (GI) tumours are one of the most prevalent cancers globally. Even with normal GI function, individuals may develop neoplasms, highlighting the need to better understand the underlying causes of tumorigenesis. The emergence of tumour drug resistance represents the main reason for the failure of drug treatment; thus, it is ...
Mohsen Sharif‐zak +6 more
wiley +1 more source
Pathophysiology and Molecular Signalling in Osteoporosis: Linking Risk Factors to Bone Loss
Journal of Cellular and Molecular Medicine, Volume 30, Issue 9, May 2026.ABSTRACT Osteoporosis is a prevalent skeletal disorder characterised by progressive reduction in bone mass, microarchitectural deterioration, and increased fracture susceptibility. In India, approximately one‐third of the elderly population is affected by bone‐related disorders, and the global burden of osteoporosis continues to rise.
Pramoda G. +5 more
wiley +1 more source
SORBS2: A Molecular Nexus in Multisystem Diseases Through Scaffold‐Mediated Regulation
Journal of Cellular and Molecular Medicine, Volume 30, Issue 9, May 2026.ABSTRACT Sorbin and SH3 Domain Containing 2 (SORBS2), a multifunctional scaffold protein harbouring Sorbin homology (SoHo) and Src homology 3 (SH3) domains, serves as a molecular hub in human diseases by integrating cytoskeletal remodelling, signal transduction and RNA metabolic regulation. This study systematically analyses SORBS2's molecular features,
Qiwei Jia, Yong Zhang
wiley +1 more source
The hidden regulators: Non‐coding RNAs in KMT2A‐rearranged acute lymphoblastic leukemia
International Journal of Cancer, Volume 158, Issue 8, Page 2003-2012, 15 April 2026.Abstract Acute lymphoblastic leukemia (ALL) driven by KMT2A rearrangements (KMT2A‐r) is an aggressive hematologic malignancy with poor prognosis and a high incidence in infants. While KMT2A fusion proteins drive leukemogenesis through transcriptional dysregulation, recent discoveries have highlighted the pivotal role of non‐coding RNAs (ncRNAs) in ...
Maria Augusta Poersch +5 more
wiley +1 more source
Synthetically designed circRNA can be used to target cardiovascular relevant microRNAs to improve cellular function. [PDF]
Sci RepBöttcher S +6 more
europepmc +1 more source
Circles within circles: commentary on Ghosal et al. (2013) “Circ2Traits: a comprehensive database for circular RNA potentially associated with disease and traits†[PDF]
, 2015 John M. Hancock
core +2 more sources
Circular RNA as emerging precision therapeutics: from RNA regulation to peptide translation. [PDF]
Precis Clin MedWu N, Amalraj J, Yang BB.
europepmc +1 more source
circRNA disease: a manually curated database of experimentally supported circRNA-disease associations [PDF]
Cell Death & Disease, 2018 Zhao, Zheng +7 more
openaire +2 more sources