Results 141 to 150 of about 28,713 (267)
Engineering a Mastoparan Peptide Concatemer Prodrug From CircRNA for Cancer Therapy [PDF]
CircRNAs are covalently closed loops of RNA formed as products of RNA backsplicing in mammalian cells. Engineered circRNAs containing a desired coding sequence have been produced using self-splicing introns.
Grewcock, Declan
core
, 2020 Objective: This research aims to explore differentially expressed circRNA between OA and KBD and potential diagnostic biomarkers.Methods: Total RNA was extracted from 5 pairs of KBD and OA knee joint cartilage specimens, and the expression of circRNAs ...
Wu, Cuiyan, +6 more
core +1 more source
Cancer Biology & MedicineObjective: Colorectal cancer (CRC) is a prevalent malignant tumor with a high fatality rate. CircPDIA4 has been shown to have a vital role in cancer development by acting as a facilitator.
Yan Zhuang +8 more
doaj +1 more source
International Journal of General Medicine, 2023 Lianbo Hu,1 Bingrong Zheng,2 Yang Yang,2 Chunmei Chen,2 Meiwei Hu2 1Physical Examination Center, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, People’s Republic of China; 2Department of ...
Hu L, Zheng B, Yang Y, Chen C, Hu M
doaj
The role of extracellular vesicles in cell–cell crosstalk in cardiotoxicity
The Journal of Physiology, EarlyView.Abstract figure legend Administration of a pharmacological agent can result in off‐target cardiotoxicity which can be driven by cell–cell crosstalk between healthy and dysfunctional cardiac cells. Extracellular vesicles (EVs) are lipid bilayer structures that can move biological cargo between cells, facilitating cell–cell crosstalk.
Gabriella Bachynskyj‐Bilas +5 more
wiley +1 more source
Clinical Significance of Has_circ_0060937 in Bone Metastasis of NSCLC
International Journal of General Medicine, 2020 Jiangnan Zhang,1 Wenwei Mao,2 Zhe Chen,2 Haiting Gu,2 Chan Lian2 1Orthopedics, The First People’s Hospital of Wenling, Wenling, Zhejiang, People’s Republic of China; 2Department of Respiratory and Critical Care Medicine, The First People ...
Zhang J, Mao W, Chen Z, Gu H, Lian C
doaj
Journal of Inflammation Research, 2022 Qi Sun,1,2,* Zhen Liu,1,2,* Xiangya Xu,1,* Yujuan Yang,1,2 Xiao Han,1,2 Cai Wang,1– 3 Fei Song,1,2,4 Yakui Mou,1,2 Yumei Li,1,2 Xicheng Song1,2 1Department of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao ...
Sun Q +9 more
doaj
Circular RNAs: Unlocking new avenues in cardiometabolic disease management
The Journal of Physiology, EarlyView.Abstract figure legend In the heart circular RNAs (circRNAs) function as microRNA sponges, interact with proteins and can even undergo translation. Advances in bioinformatics now enable their identification through high‐throughput RNA sequencing, whereas computational analyses reveal differential expression in cardiac disease settings.
Kimberley M. Mellor +4 more
wiley +1 more source
HNRNPD regulates the biogenesis of circRNAs and the ratio of mRNAs to circRNAs for a set of genes
RNA BiologyExonic circular RNAs (ecircRNAs) in animal cells are generated by backsplicing, and the biogenesis of ecircRNAs is regulated by an array of RNA binding proteins (RBPs). HNRNPD is a heterogeneous nuclear ribonucleoprotein family member with both cytoplasmic and nuclear roles, and whether HNRNPD regulates the biogenesis of circRNAs remains unknown.
Shuhui Chang +8 more
openaire +3 more sources
Biogenesis, Functions, and Role of CircRNAs in Lung Cancer
Cancer Management and Research, 2021 Huanhuan Dong,* Junliang Zhou,* Yue Cheng, Meiqi Wang, Shuqing Wang, Hui Xu Department of Clinical Laboratory, Harbin Medical University Cancer Hospital, Harbin, 150081, People’s Republic of China*These authors contributed equally to this ...
Dong H +5 more
doaj