Results 121 to 130 of about 34,260 (269)

The RNA workbench: Best practices for RNA and high-throughput sequencing bioinformatics in Galaxy [PDF]

, 2017
RNA-based regulation has become a major research topic in molecular biology. The analysis of epigenetic and expression data is therefore incomplete if RNA-based regulation is not taken into account. Thus, it is increasingly important but not yet standard
Akalin, A. (Altuna), Backofen, R. (Rolf), Bagnacani, A. (Andrea), Batut, B. (Bérénice), Eggenhofer, F. (Florian), Erxleben, A. (Anika), Fallmann, J. (Jörg), Grüning, B.A. (Björn A.), Hess, W.R. (Wolfgang R.), Hoffmann, S. (Steve), Hoogstrate, Y. (Youri), Houwaart, T. (Torsten), Lott, S.C. (Steffen C.), Ohler, U. (Uwe), Stadler, P.F. (Peter F.), Videm, P. (Pavankumar), Will, S. (Sebastian), Wolfien, M. (Markus), Wolkenhauer, O. (Olaf), Yusuf, D. (Dilmurat)   +19 more
core   +6 more sources

Role of ZNF652 in Regulating Hepatocellular Carcinoma Cell Proliferation and Apoptosis via the circRHOT1/SLC38A6 Axis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Hepatocellular carcinoma (HCC) is a heterogeneous malignancy characterized by high mortality rates. This article presents a discussion of the role of ZNF652 in HCC cell proliferation and apoptosis, thereby identifying a new target for HCC treatment. The expression levels of ZNF652, circRHOT1, and SLC38A6 in HCC and healthy cells were analyzed.
Kang Chen, Fei‐Hu Sun, Chen Fan, Wei Ding, Hao‐Huan Tang, Lei Sun, Wei‐Tao Wang, Wei‐Dong Wang   +7 more
wiley   +1 more source

CircRNA: Functions, Applications and Prospects

Biomolecules
Circular RNAs (circRNAs) represent a distinct class of covalently closed non-coding RNA molecules characterized by the absence of free 5′ and 3′ ends [...]
Fei Xu, Qing Xiao, William W. Du, Sheng Wang, Burton B. Yang   +4 more
openaire   +3 more sources

Colorectal cancer: from the genetic model to posttranscriptional regulation by noncoding RNAs [PDF]

, 2017
Colorectal cancer is the third most common form of cancer in developed countries and, despite the improvements achieved in its treatment options, remains as one of the main causes of cancer-related death.
Calle Espinosa, Jorge, Fernández Lizarbe, Eva, Fernández Lizarbe, Sara, Lizarbe, María Antonia, Olmo López, Nieves, Robles, Miguel Ángel, Turnay, Javier   +6 more
core   +4 more sources

Circ_0006174 Drives Triple Negative Breast Cancer Progression and Immune Escape Through Regulating miR‐3139/PD‐L1 Axis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Triple‐negative breast cancer (TNBC) is characterized as an aggressive malignancy with limited therapeutic options. The circular RNA circ_0006174 has been implicated in oncogenic processes across various cancers; however, its specific role in the pathogenesis of TNBC remains unclear.
Yong‐Zhe Tang, Li Yang, Ling Wang, Xiao‐Qing Zhang, Jie Wang   +4 more
wiley   +1 more source

Synergistic Immunoregulation: harnessing CircRNAs and PiRNAs to Amplify PD-1/PD-L1 Inhibition Therapy

International Journal of Nanomedicine
Rui Han,1,2 Xiwu Rao,3 Huiling Zhou,4 Lingeng Lu5– 7 1Department of Chinese Medicine Oncology, The First Affiliated Hospital of Naval Medical University, Shanghai, People’s Republic of China; 2Department of Chinese Medicine, Naval Medical University ...
Han R, Rao X, Zhou H, Lu L
doaj  

RNA‐binding protein RBMS1: A new target for cancer diagnosis and treatment

Precision Medical Sciences, EarlyView.
This schematic illustrates the diverse regulatory roles of RNA‐binding motif single‐stranded interacting protein 1 (RBMS1) across multiple human cancers. In breast cancer, RBMS1 stabilizes B4GALT1 mRNA to promote PD‐L1 glycosylation, modulating tumor immune escape and immunotherapy efficacy.
Xingda Run, Shiwei Jiang, Kun Xu, Yu Fan, Yanwen Chen, Ziao Liu, Zengli Miao, Wei Tian   +7 more
wiley   +1 more source

Extracellular RNA in Central Nervous System Pathologies [PDF]

, 2019
The discovery of extracellular RNA (exRNA) has shifted our understanding of the role of RNA in complex cellular functions such as cell-to-cell communication and a variety of pathologies.
Fischer, Silvia, Preissner, Klaus T., Tielking, Katharina, Vajkoczy, Peter, Xu, Ran   +4 more
core   +1 more source

Whole‐transcriptome sequencing analyses identified exosomal circular RNAs in the plasma of pancreatic cancer patients as novel blood‐based biomarkers of disease

VIEW, EarlyView.
Pancreatic cancer (PaCa) has a poor prognosis, with low resection rates and high relapse rates, highlighting the urgent need for novel diagnostic biomarkers. Here, we performed whole‐transcriptome sequencing of plasma‐derived exosomes from PaCa patients and identified several differentially expressed circular RNAs (circRNAs).
Xiaomeng He, Yang Di, Lixiang Sun, Zhirong Wu, Mengting Luo, Xin Zhang, Huaqin Sun, Wanli Xu, Wenchuan Wu, Boheng Zhang, Jin Wang   +10 more
wiley   +1 more source

The Non-Coding RNA Ontology : a comprehensive resource for the unification of non-coding RNA biology [PDF]

, 2016
In recent years, sequencing technologies have enabled the identification of a wide range of non-coding RNAs (ncRNAs). Unfortunately, annotation and integration of ncRNA data has lagged behind their identification.
Alan, Ruttenberg, Blake Judith, A., Dejing, Dou, Jingshan, Huang, Jun, Huan, Karen, Eilbeck, Natale Darren, A., Smith, Barry, Weili, Huang, Zimmermann Michael, T.   +9 more
core