Results 131 to 140 of about 34,260 (269)
VIEW, EarlyView.Cancer‐associated fibroblasts exert intricate mechanisms in the progression and metastasis of renal cell carcinoma. Existing studies have validated the relevant mechanisms of three signaling pathways, which hold promising potential as novel therapeutic targets.
Ruiqiang Sun +4 more
wiley +1 more source
Allergy, EarlyView.ABSTRACT In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal ...
F. Roth‐Walter +20 more
wiley +1 more source
Bioinformatics evaluation of the circRNA–miRNA–mRNA axis in cervical squamous cell carcinoma
Exploration of MedicineAim: Cervical squamous cell carcinoma (CESC) is a highly prevalent women’s gynecologic disease. Because the specific mechanisms associated with the illness are still mostly unclear, more investigation is needed to comprehend the triggers of CESC’s ...
Murat KAYA
doaj +1 more source
A ceRNA approach may unveil unexpected contributors to deletion syndromes, the model of 5q- syndrome [PDF]
, 2015 In genomic deletions, gene haploinsufficiency might directly configure a specific disease phenotype. Nevertheless, in some cases no functional association can be identified between haploinsufficient genes and the deletion-associated phenotype ...
Arancio, W. +3 more
core +2 more sources
Brain Pathology, EarlyView.circRMST (hsa_circ_0099634) is by far the most abundant isoform from the RMST locus. It is highly expressed in cancer cells throughout ependymoma patient samples and is located in the cytoplasm. circRMST knockdown causes cell cycle arrest and induces differentiation, and it is a marker for poor prognosis. The figure is made using BioRender.
Ulvi Ahmadov +6 more
wiley +1 more source
Writing a wrong: Coupled RNA polymerase II transcription and RNA quality control [PDF]
, 2019 Processing and maturation of precursor RNA species is coupled to RNA polymerase II transcription. Co-transcriptional RNA processing helps to ensure efficient and proper capping, splicing, and 3' end processing of different RNA species to help ensure ...
Hughes, Katlyn D. +3 more
core +1 more source
Targeting the microbiota‐miRNA‐protease axis: A new therapeutic avenue in melanoma
The FEBS Journal, EarlyView.Modulation of extracellular matrix (ECM) turnover is central to melanoma progression and metastasis, driven largely by ECM proteases. This review highlights the epigenetic regulation of ECM proteases by microRNAs and their roles in melanoma growth, invasion, and immune modulation.
Elias N. Katsoulieris +2 more
wiley +1 more source
Peri‐Implantitis and Periodontitis: Biological Convergence, Contextual Divergence
Journal of Periodontal Research, EarlyView.Periodontal and peri‐implant tissues differ and coincide in many aspects, from the clinical and radiological perspective, including histology, microbiology, and molecular markers. Thus, health and disease may also follow different and similar routes.
Pablo Galindo‐Moreno +6 more
wiley +1 more source
Direct circRNA-mRNA Binding Controls mRNA Fate: A New Mechanism for circRNAs
Non-Coding RNACircular RNAs (circRNAs) are covalently closed RNA molecules generated through a non-canonical splicing event known as back-splicing. This particular class of non-coding RNAs has attracted growing interest due to its evolutionary conservation across eukaryotes, high expression in the central nervous system, and frequent dysregulation in various ...
Raffaele Garraffo, Manuel Beltran Nebot
openaire +2 more sources