Results 101 to 110 of about 34,260 (269)

Nanopore direct RNA sequencing maps the complexity of Arabidopsis mRNA processing and m6A modification [PDF]

, 2020
Understanding genome organization and gene regulation requires insight into RNA transcription, processing and modification. We adapted nanopore direct RNA sequencing to examine RNA from a wild-type accession of the model plant Arabidopsis thaliana and a ...
Barton, Geoffrey J., Gould, Peter D., Hall, Anthony J. W., Knop, Katarzyna, Mackinnon, Katarzyna, Parker, Matthew T., Schurch, Nicholas J., Sherwood, Anna V., Simpson, Gordon G.   +8 more
core   +3 more sources

CCL26‐Mediated Modulation of Endothelial Secretome by Hypoxia‐Induced Tumor‐Derived Exosomes Enhances Metastatic Progression in Head and Neck Cancer

Head &Neck, EarlyView.
ABSTRACT Background Tumor cells adapt to hypoxia by releasing hiTDExs enriched with bioactive molecules that modulate endothelial behavior and promote tumor progression. This study aimed to characterize how hypoxia‐induced HNSCC exosomes reshape the endothelial secretome and contribute to metastatic potential.
Ozel Capik, Sevil Tekman, Betul Gundogdu, Ahsen Kilic, Rumeysa Polat, Omer Aydin, Omer Faruk Karatas   +6 more
wiley   +1 more source

Tumor‐educated platelets in cancer diagnostics and prognostics: A critical appraisal and roadmap for clinical translation

International Journal of Cancer, EarlyView.
Abstract Tumor‐educated platelets (TEPs) are emerging as a compelling frontier in liquid biopsy, functioning as dynamic, systemic sensors that sequester and process tumor‐derived biomolecules. This interaction imprints an integrated molecular signature of malignancy—spanning the transcriptome, proteome, lipidome, and crucially, the captured genome ...
Whi‐An Kwon, Min‐Kyung Lee, Eunyong Ahn, Heeyeon Kim, Yong Sang Song, Taejin Ahn   +5 more
wiley   +1 more source

Recent Update on the Role of Circular RNAs in Hepatocellular Carcinoma

Journal of Hepatocellular Carcinoma, 2021
Abdullah Ely, Kristie Bloom, Mohube Betty Maepa, Patrick Arbuthnot Wits/SAMRC Antiviral Gene Therapy Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South AfricaCorrespondence: Patrick ...
Ely A, Bloom K, Maepa MB, Arbuthnot P
doaj  

Transcriptional and Post-transcriptional Gene Regulation by Long Non-coding RNA. [PDF]

, 2017
Advances in genomics technology over recent years have led to the surprising discovery that the genome is far more pervasively transcribed than was previously appreciated.
An, Andersson, Augoff, Bartel, Beermann, Broadbent, Cai, Calin, Carrieri, Chen, Chu, Cloonan, Costanza Emanueli, de Hoon, de Pontual, Diederichs, Djebali, Elton, Gabory, Gabory, Gao, Geisler, Gong, Gonzalez, Guttman, Hangauer, Hansen, Hansen, Hindorff, Iain M. Dykes, Imig, Ishii, Johnson, Johnsson, Kallen, Kampa, Kapranov, Kapranov, Kasar, Keniry, Khalil, Kim, Kim, Kim, Kino, Kretz, Krumlauf, Kumar, Lai, Lam, Lee, Leppek, Lerner, Li, Li, Li, Li, Luco, Malik, Mattick, Memczak, Mercer, Milligan, Monnier, Morenos, Mousavi, Nagano, Nagano, Novikova, Ong, Orom, Orom, Palazzo, Pandey, Papanayotou, Park, Pastori, Pegueroles, Poliseno, Rinn, Rinn, Rinn, Ripoche, Rutnam, Saini, Salmena, Salzman, Salzman, Sarma, Seitz, Siomi, Slezak-Prochazka, Smith, Somarowthu, Sotelo, Srisawat, St Laurent, Tam, Thomas, Thomson, Tripathi, Tsai, Underwood, Wan, Wang, Wang, Wang, Winter, Xiang, Yang, Yoon, Zemel, Zeng   +112 more
core   +4 more sources

Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials

iNew Medicine, EarlyView.
ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong, Xiao‐Yu Shen, Han‐Cheng Jin, Xiang‐Yu Li, Hao He, Xiao‐Ming Meng   +5 more
wiley   +1 more source

Genome-Wide Profiling of Circular RNAs in the Rapidly Growing Shoots of Moso Bamboo (Phyllostachys edulis). [PDF]

, 2019
Circular RNAs, including circular exonic RNAs (circRNA), circular intronic RNAs (ciRNA) and exon-intron circRNAs (EIciRNAs), are a new type of noncoding RNAs.
Gao, Yubang, Gu, Lianfeng, Hu, Kaiqiang, Kohnen, Markus V, Lin, Chentao, Liu, Xuqing, Wang, Huihui, Wang, Huiyuan, Wang, Yongsheng, Xi, Feihu, Xu, Xi, Zhang, Hangxiao, Zhang, Zeyu, Zhao, Liangzhen   +13 more
core  

Insulin Resistance: An Update on Biochemical and Pathophysiological Mechanisms and Impact on Various Diseases

iNew Medicine, EarlyView.
ABSTRACT Insulin resistance is the biological phenomenon in which the human body's normal response to the metabolic hormone insulin is compromised. Insulin is a regulator of most of the essential metabolic steps in the body that control energy homoeostasis, so dysregulation leads to multiple diverse human diseases including, most prominently, Type 2 ...
Peter J. Little, Stefan Offermanns, Haaglim Cho, Zhiping Liu, Pinglian Yang, Qiaozhu Su, Henry Wade, Wah Yang, Danielle Kamato, Neale Cohen, Alex Bobik, Iqra Ilyas, Suowen Xu   +12 more
wiley   +1 more source

Recent advances in malaria genomics and epigenomics [PDF]

, 2016
Malaria continues to impose a significant disease burden on low- and middle-income countries in the tropics. However, revolutionary progress over the last 3 years in nucleic acid sequencing, reverse genetics, and post-genome analyses has generated step ...
Kirchner, Sebastian, Power, B. Joanne, Waters, Andrew P.   +2 more
core   +1 more source

N6‐Methyladenosine (m6A) in Liver Disease: Pathogenic Mechanisms and Therapeutic Potential

iNew Medicine, EarlyView.
ABSTRACT Accumulating evidence highlights the critical role of epigenetic modifications, particularly N6‐methyladenosine (m6A), in liver disease. As the most abundant RNA modification in eukaryotic cells, m6A is dynamically regulated by multicomponent m6A methyltransferases (e.g., METTL3 and METTL14), demethylases (FTO and ALKBH5), and m6A‐binding ...
Yingfen Chen, Ru Ya, Ziling Zhang, Siyue Dong, Seol Hee Park, Wonhyo Seo, Yong He   +6 more
wiley   +1 more source