Results 101 to 110 of about 28,713 (267)

Exosomal CircRNAs in Circulation Serve as Diagnostic Biomarkers for Acute Myocardial Infarction

Frontiers in Bioscience-Landmark
Background: The diagnostic potential of circular RNAs (circRNAs) in circulating exosomes for acute myocardial infarction (AMI) is not well understood, despite existing research indicating their role in cardiovascular diseases. This study aimed to clarify
Xiaoyan Liu, Yeping Zhang, Wen Yuan, Ruijuan Han, Jiuchang Zhong, Xinchun Yang, Meili Zheng, Boqia Xie   +7 more
doaj   +1 more source

Novel Organelle‐Based Intracellular Immunity With Mechanistic and Therapeutic Implications

Barrier Immunity, EarlyView.
A conceptual framework illustrating how PAMPs/DAMPs initiate barrier, innate, adaptive, and intracellular immune responses, with organelle‐based intracellular immunity serving as a central integrator linking metabolism, inflammatory signaling, and therapeutic interventions to restore immune homeostasis.
Keman Xu, Shih‐Yu Hung, Fatma Saaoud, Ying Shao, Yifan Lu, Juanjuan Liu, Bo Yuan, Haiyan Xiang, Hong Wang, Xiaofeng Yang   +9 more
wiley   +1 more source

circRNA meets gene amplification [PDF]

Non-coding RNA Investigation, 2018
Lung cancer remains the most common cause of cancer related death among both males and females globally accounting for 1.69 million deaths in 2015 (1). Of the different types of lung cancer, lung adenocarcinoma (LAC) is the most common (2). Given the prevalence and lethality of lung cancer the need to elucidate the mechanisms of this disease and to ...
Nicholas, Manguso, Armando E, Giuliano, Hisashi, Tanaka   +2 more
openaire   +2 more sources

Table6_High-Throughput Sequencing to Investigate lncRNA-circRNA-miRNA-mRNA Networks Underlying the Effects of Beta-Amyloid Peptide and Senescence on Astrocytes.XLS

, 2022
Astrocytes are widely distributed in the central nervous system and play an essential role in the function of neuronal cells. Associations between astrocytes and Alzheimer’s disease (AD) have been noted, and recent work has implicated circular RNA ...
Jiuyang Ding (9509180), Yuxin Deng (8502648), Yi Zhao (14034), Xiaolan Qi (11954006), Yan Xiao (91196), Hui Song (53547), Liangzao Chu (12533263), Xiangchun Shen (4614574)   +7 more
core   +1 more source

Transcriptomic signatures reveal systemic adaptations and immune modulation in response to training and competitive racing in horses

Equine Veterinary Journal, EarlyView.
Abstract Background The molecular mechanisms underlying adaptation to physical exertion and racing stress in horses remain incompletely understood. Peripheral blood transcriptomics offers a minimally invasive method to monitor systemic responses to exercise and identify biomarkers of adaptation or overload. Objectives To evaluate transcriptomic changes
Izabela Dąbrowska, Jowita Grzędzicka‐Agko, Paula Kiełbik, Michał Trela, Olga Witkowska‐Piłaszewicz   +4 more
wiley   +1 more source

Table5_High-Throughput Sequencing to Investigate lncRNA-circRNA-miRNA-mRNA Networks Underlying the Effects of Beta-Amyloid Peptide and Senescence on Astrocytes.XLSX

, 2022
Astrocytes are widely distributed in the central nervous system and play an essential role in the function of neuronal cells. Associations between astrocytes and Alzheimer’s disease (AD) have been noted, and recent work has implicated circular RNA ...
Jiuyang Ding (9509180), Yuxin Deng (8502648), Yi Zhao (14034), Xiaolan Qi (11954006), Yan Xiao (91196), Hui Song (53547), Liangzao Chu (12533263), Xiangchun Shen (4614574)   +7 more
core   +1 more source

CCL26‐Mediated Modulation of Endothelial Secretome by Hypoxia‐Induced Tumor‐Derived Exosomes Enhances Metastatic Progression in Head and Neck Cancer

Head &Neck, EarlyView.
ABSTRACT Background Tumor cells adapt to hypoxia by releasing hiTDExs enriched with bioactive molecules that modulate endothelial behavior and promote tumor progression. This study aimed to characterize how hypoxia‐induced HNSCC exosomes reshape the endothelial secretome and contribute to metastatic potential.
Ozel Capik, Sevil Tekman, Betul Gundogdu, Ahsen Kilic, Rumeysa Polat, Omer Aydin, Omer Faruk Karatas   +6 more
wiley   +1 more source

Intron-mediated enhancement boosts Rtn4 circRNA expression: A robust method for exploring circRNA function

, 2018
CircRNAs are expressed in many important biological processes. Studying their function requires an effective expression method. When we used intron-mediated enhancement (IME) to improve circRNA expression of mouse Rtn4 (Nogo, a key protein in Nogo-Rho ...
Jeanne-Franca Vollmar, Xinping Li, Di Cui, Dingding Mo   +3 more
core   +1 more source

circRNA-miRNA-hub gene subnetwork.

, 2021
The network consists of 24circRNAs, 3 miRNAs and 10 mRNAs. The rectangles indicate miRNAs, the diamonds indicate circRNAs, and the ellipses indicate mRNAs. The red nodes represent increased expression, and the blue nodes represent decreased expression.
Tao-Lin Xia (11790741), Liang Luo (425058), Lei-Lei Zhang (4348597), Wen Tao (848995), Liao-Yuan Li (2328004)   +4 more
core   +1 more source

The lariat-derived circRNA from ATXN2L: an outstanding circRNA in pigs

, 2021
International audienceIn contrast to exon-derived circular RNAs (exonic circRNAs), which are widely studied, much less in known on intron-derived circRNAs: when intron lariats escape degradation due to debranching failure they can become circRNA ...
Faraut, Thomas, Robic, Annie, Cerutti, Chloé, Kühn, Christa, Demars, Julie   +4 more
core   +1 more source