Results 81 to 90 of about 30,287 (286)

Identification of a Circular RNA as a Potential Diagnostic and Prognostic Biomarker in Breast Cancer Through Integrated Bioinformatic and Experimental Analyses. [PDF]

Anal Sci Adv
Forty circular RNAs were found to be significantly dysregulated in microarray datasets. Expression levels of hsa_circ_0000231 were significantly upregulated in breast cancer (BC) tissues, while hsa_circ_0011385 exhibited no significant difference in expression levels. This study also revealed that hsa_circ_0000231/hsa‐miR‐5683/CCNB1 regulatory axis may
Hashemi M, Morovat P, Khoshghiafeh A, Nikbakhsh N, Ahmadifard M.   +4 more
europepmc   +2 more sources

CircRNA Expression Profiling

, 2022
CircRNA Expression ...
Chen Li (11849867)
core   +1 more source

Roles of circRNAs in hematological malignancies

Biomarker Research, 2022
AbstractAs one of the leading causes of death, hematologic malignancies are associated with an ever-increasing incidence, and drug resistance and relapse of patients after treatment represent clinical challenges. Therefore, there are pressing demands to uncover biomarkers to indicate the development, progression, and therapeutic targets for hematologic
Fahua Deng, Chengsi Zhang, Tingting Lu, Ezhong Joshua Liao, Hai Huang, Sixi Wei   +5 more
openaire   +3 more sources

circZNF148 Drives Glucose Metabolism Reprogramming to Enhance Metastasis and Immune Evasion via HK1 Stabilization in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
CircZNF148 stabilizes HK1 through deubiquitinase recruitment, thereby enhancing glycolysis and lactate production. Elevated lactate promotes PD‑L1 lactylation and membrane accumulation while suppressing CD8+ T‐cell cytotoxicity, collectively facilitating immune evasion and malignant progression in TNBC.
Yuhan Jin, Wenjing Zhao, Lei Wang, Jianing Wang, Keying Zhao, Dan Luo, Yifei Wang, Yuxia Yang, Jingze Yang, Yaming Li, Tong Chen, Dianwen Han, Zekun Wang, Xiaoyan Li, Bing Chen, Lijuan Wang, Yiran Liang, Qifeng Yang   +17 more
wiley   +1 more source

Circular RNAs: implications of signaling pathways and bioinformatics in human cancer

Cancer Biology & Medicine, 2023
Circular RNAs (circRNAs) form a class of endogenous single-stranded RNA transcripts that are widely expressed in eukaryotic cells. These RNAs mediate post-transcriptional control of gene expression and have multiple functions in biological processes ...
Fan Hu, Yin Peng, Xinmin Fan, Xiaojing Zhang, Zhe Jin   +4 more
doaj   +1 more source

Table6_High-Throughput Sequencing to Investigate lncRNA-circRNA-miRNA-mRNA Networks Underlying the Effects of Beta-Amyloid Peptide and Senescence on Astrocytes.XLS

, 2022
Astrocytes are widely distributed in the central nervous system and play an essential role in the function of neuronal cells. Associations between astrocytes and Alzheimer’s disease (AD) have been noted, and recent work has implicated circular RNA ...
Jiuyang Ding (9509180), Yuxin Deng (8502648), Yi Zhao (14034), Xiaolan Qi (11954006), Yan Xiao (91196), Hui Song (53547), Liangzao Chu (12533263), Xiangchun Shen (4614574)   +7 more
core   +1 more source

A Multidimensional Engineering Strategy Reprograms Microglia via Targeted and Sustained‐Release Extracellular Vesicles for Spinal Cord Injury Repair

Advanced Science, EarlyView.
A multifunctional EV‐based nanoplatform (Ang‐TEVs@Gel) was engineered via preconditioning, surface targeting, and ROS‐responsive hydrogel encapsulation to reprogram microglia. This system restored autophagy via miR‐664a‐3p/PIK3CA axis, cleared myelin debris, resolved neuroinflammation, and promoted axon remyelination, ultimately achieving robust motor ...
Wu Xiong, Minhao Liu, Mingming Zheng, Jizhou Jia, Ziyan Zhu, Guang Kong, Jie Liu, Juan Wang, Wenbo Li, Qingyuan Wang, Qian Zhu, Peiran Chan, Tao Qin, Jiayang Wu, Yongjie Zhang, Chunming Tang, Cong Li, Jin Fan   +17 more
wiley   +1 more source

Role of non-coding RNAs in skin photoaging

Pifu-xingbing zhenliaoxue zazhi
Skin photoaging, a phenomenon of premature skin aging due to prolonged exposure to ultraviolet (UV) radiation, manifests as wrinkles, loss of skin elasticity, pigmentation disorders, and age spots.
HE Zezhi, CHEN Jiazhen, WU Hui, SHEN Haojia, LI Runxiang, ZHU Huilan   +5 more
doaj   +1 more source

Table1_High-Throughput Sequencing to Investigate lncRNA-circRNA-miRNA-mRNA Networks Underlying the Effects of Beta-Amyloid Peptide and Senescence on Astrocytes.XLSX

, 2022
Astrocytes are widely distributed in the central nervous system and play an essential role in the function of neuronal cells. Associations between astrocytes and Alzheimer’s disease (AD) have been noted, and recent work has implicated circular RNA ...
Jiuyang Ding (9509180), Yuxin Deng (8502648), Yi Zhao (14034), Xiaolan Qi (11954006), Yan Xiao (91196), Hui Song (53547), Liangzao Chu (12533263), Xiangchun Shen (4614574)   +7 more
core   +1 more source

CircRNA: a rising star in leukemia

PeerJ, 2023
Non-coding RNA are a class of RNA that lack the potential to encode proteins. CircRNAs, generated by a post-splicing mechanism, are a newly discovered type of non-coding RNA with multi-functional covalent loop structures. CircRNAs may play an important role in the occurrence and progression of tumors.
Li, Qianan, Ren, Xinxin, Wang, Ying, Xin, Xiaoru   +3 more
openaire   +3 more sources