Results 71 to 80 of about 34,489 (213)

Circular RNAs: implications of signaling pathways and bioinformatics in human cancer

Cancer Biology & Medicine, 2023
Circular RNAs (circRNAs) form a class of endogenous single-stranded RNA transcripts that are widely expressed in eukaryotic cells. These RNAs mediate post-transcriptional control of gene expression and have multiple functions in biological processes ...
Fan Hu, Yin Peng, Xinmin Fan, Xiaojing Zhang, Zhe Jin   +4 more
doaj   +1 more source

Reconstruction of Full-Length circRNA Sequences Using Chimeric Alignment Information

, 2022
Circular RNAs (circRNAs) are RNA molecules formed by joining a downstream 3 splice donor site and an upstream 5 splice acceptor site. Several recent studies have identified circRNAs as potential biomarker for different diseases.
Zhang, Jingjing, Yanjie Wei, Yin Peng, Wei, Yanjie, Hossain, Md. Tofazzal, Peng, Yin, Md. Selim Reza, Reza, Md. Selim, Shengzhong Feng, Jingjing Zhang, Md. Tofazzal Hossain, Feng, Shengzhong   +11 more
core   +1 more source

Amcinonide Exhibits Antitumor Effects in Radioresistant Colorectal Cancer Through the circRNF10/miR‐296‐5p/Snail Axis

Advanced Science, EarlyView.
Amcinonide (AMC), the FDA‐approved corticosteroid, was identified as a repurposed agent for radiation‐resistant colorectal cancer. AMC suppresses radiation‐induced epithelial–mesenchymal transition, migration, and invasion via the circRNF10/miR‐296‐5p/Snail axis.
Hyun Jeong Seok, Dong Hyeon Lee, Junhye Kwon, Ui Sup Shin, In Hwa Bae   +4 more
wiley   +1 more source

Role of non-coding RNAs in skin photoaging

Pifu-xingbing zhenliaoxue zazhi
Skin photoaging, a phenomenon of premature skin aging due to prolonged exposure to ultraviolet (UV) radiation, manifests as wrinkles, loss of skin elasticity, pigmentation disorders, and age spots.
HE Zezhi, CHEN Jiazhen, WU Hui, SHEN Haojia, LI Runxiang, ZHU Huilan   +5 more
doaj   +1 more source

HMCDA: a novel method based on the heterogeneous graph neural network and metapath for circRNA-disease associations prediction [PDF]

, 2023
Circular RNA (CircRNA) is a type of non-coding RNAs in which both ends are covalently linked. Researchers have demonstrated that many circRNAs can act as biomarkers of diseases.
Liu, Siwei, Shiyang Liang, Song, Junliang, Shihong Zhao, Lin, Qiang, Shuaixin Li, Shangsong Liang, Junliang Song, Li, Shuaixin, Liang, Shiyang, Jiahui Li, Jingjie Wang, Siwei Liu, Qiang Lin, Zhao, Shihong, Li, Jiahui, Wang, Jingjie, Liang, Shangsong   +17 more
core   +1 more source

Extracellular Vesicles‐Based Biological Macromolecule Delivery Systems: Biogenesis, Characterization, and Emerging Clinical Applications

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are nanoscale membrane‐bound structures that play a pivotal role in intercellular communication by transporting bioactive molecules, including proteins, lipids, nucleic acids, and organelles, between cells. Originating from the endosomal pathway, EVs reflect the physiological and pathological status of their parent
Emine İncilay Torunoğlu, Zeynep Betül Sarı, Muhammed Emin Sarı, Erdi Can Aytar   +3 more
wiley   +1 more source

Exosomal CircRNAs in Circulation Serve as Diagnostic Biomarkers for Acute Myocardial Infarction

Frontiers in Bioscience-Landmark
Background: The diagnostic potential of circular RNAs (circRNAs) in circulating exosomes for acute myocardial infarction (AMI) is not well understood, despite existing research indicating their role in cardiovascular diseases. This study aimed to clarify
Xiaoyan Liu, Yeping Zhang, Wen Yuan, Ruijuan Han, Jiuchang Zhong, Xinchun Yang, Meili Zheng, Boqia Xie   +7 more
doaj   +1 more source

The top 20 circRNA-disease associations.

, 2023
Accumulating evidence suggests that circRNAs play crucial roles in human diseases. CircRNA-disease association prediction is extremely helpful in understanding pathogenesis, diagnosis, and prevention, as well as identifying relevant biomarkers.
Jiawang Zhao (16913631), Qinhu Zhang (12219347), Chun-Hou Zheng (283529), De-Shuang Huang (396909), Yushui Geng (16913634), Lin Yuan (46306), Zhen Shen (393133)   +6 more
core   +1 more source

Increased Insulin Action, Glucose Metabolism and Muscle Function in Supervillin‐Knockout and Supervillin‐Mutant Mice

Cytoskeleton, EarlyView.
ABSTRACT We here describe mouse models with complementary homozygous Svil mutations. In skeletal muscle, Svil‐Mut mice express the Svil‐encoded N‐terminus fused to the βgal‐neo gene‐trap tag and lack the highly conserved archvillin C‐terminus; Svil‐KO mice lack expression of all known Svil‐encoded proteins; and Svil‐LoxP mice contain loxP sites for ...
Tara C. Smith, Lauren A. Tauer, Randall H. Friedline, Xiaodi Hu, Duy Tran, Yangyi E. Luo, Nacima Hadjout‐Rabi, Elisabeth R. Barton, Jason K. Kim, Elizabeth J. Luna   +9 more
wiley   +1 more source

DataSheet1_Nucleotide-level prediction of CircRNA-protein binding based on fully convolutional neural network.PDF

, 2023
Introduction: CircRNA-protein binding plays a critical role in complex biological activity and disease. Various deep learning-based algorithms have been proposed to identify CircRNA-protein binding sites.
ShuJun Zhao (17106088), SiGuo Wang (17106094), QinHu Zhang (17106091), Zhen Shen (393133), Lin Yuan (46306), Wei Liu (20030)   +5 more
core   +1 more source