Results 61 to 70 of about 24,361 (224)

Review of the Molecular and Developmental Basis of Myhre Syndrome, Bench Research

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Myhre syndrome (MS) is a connective‐tissue disorder within the acromelic dysplasia spectrum. It is characterized by congenital craniofacial, skeletal, cutaneous anomalies, respiratory, cardiovascular along with intellectual disability, deafness, and progressive fibrosis.
Camille Viaut, Valerie Cormier‐Daire
wiley   +1 more source

Circular RNAs: implications of signaling pathways and bioinformatics in human cancer

Cancer Biology & Medicine, 2023
Circular RNAs (circRNAs) form a class of endogenous single-stranded RNA transcripts that are widely expressed in eukaryotic cells. These RNAs mediate post-transcriptional control of gene expression and have multiple functions in biological processes ...
Fan Hu, Yin Peng, Xinmin Fan, Xiaojing Zhang, Zhe Jin   +4 more
doaj   +1 more source

One‐step generation of heritable mitochondrial DNA multiplex‐engineered rats using DddA‐derived cytosine base editor

Animal Models and Experimental Medicine, EarlyView.
We established that mixed DdCBE microinjection is an efficient, heritable, and precise strategy for generating multiplex mtDNA mutant rats. This advancement significantly expands the utility of DdCBEs for mitochondrial disease modeling, providing a robust platform for exploring the pathogenic mechanisms of complex mtDNA mutations and developing ...
Xu Zhang, Keru Li, Lei Tan, Wei Chen, Shan Gao, Chenyang Liu, Shuo Pan, Jiayue He, Ning Liu, Gefan Wan, Wei Dong, Weining Kong, Bin Shen, Xiaolong Qi, Yuanwu Ma   +14 more
wiley   +1 more source

Role of non-coding RNAs in skin photoaging

Pifu-xingbing zhenliaoxue zazhi
Skin photoaging, a phenomenon of premature skin aging due to prolonged exposure to ultraviolet (UV) radiation, manifests as wrinkles, loss of skin elasticity, pigmentation disorders, and age spots.
HE Zezhi, CHEN Jiazhen, WU Hui, SHEN Haojia, LI Runxiang, ZHU Huilan   +5 more
doaj   +1 more source

Zirkuläre, Photogeschützte mRNA für Lichtinduzierte Aktivierung der Translation zu späten Zeitpunkten

Angewandte Chemie, EarlyView.
Eine klickbare, photogeschützte 5′‐Kappe (CyCliCap) zur Herstellung von zyklischer, Click‐Cap enthaltender mRNA (Cyclic Click Cap‐mRNA), die bis zur Bestrahlung beachtlich stabil und translational stumm ist, ermöglicht die Aktivierung der Translation in Zellen zu späten Zeitpunkten mittels Lichts. ZUSAMMENFASSUNG mRNA ist eine neue Impfstofftechnologie
Bayram Terzi, Greta Charlotte Dahm, Kristoffer Heintz, Martin Sumser, Yasuaki Kimura, Hiroshi Abe, Andrea Rentmeister   +6 more
wiley   +1 more source

Exosomal CircRNAs in Circulation Serve as Diagnostic Biomarkers for Acute Myocardial Infarction

Frontiers in Bioscience-Landmark
Background: The diagnostic potential of circular RNAs (circRNAs) in circulating exosomes for acute myocardial infarction (AMI) is not well understood, despite existing research indicating their role in cardiovascular diseases. This study aimed to clarify
Xiaoyan Liu, Yeping Zhang, Wen Yuan, Ruijuan Han, Jiuchang Zhong, Xinchun Yang, Meili Zheng, Boqia Xie   +7 more
doaj   +1 more source

Circular Photocaged mRNA for Light‐induced Late‐stage Activation of Translation

Angewandte Chemie International Edition, EarlyView.
A clickable photo‐caged 5′ cap (CyCliCap) allows to make Cyclic Click Cap‐containing mRNA (CyCliCap‐mRNA) which is remarkably stable and translationally muted until irradiated, allowing for late‐stage activation of translation in cells by light. ABSTRACT mRNA is a new medical modality as vaccine and raises hopes to become a protein replacement agent ...
Bayram Terzi, Greta Charlotte Dahm, Kristoffer Heintz, Martin Sumser, Yasuaki Kimura, Hiroshi Abe, Andrea Rentmeister   +6 more
wiley   +1 more source

The Roles of CircRNAs in Mitochondria

Journal of Cancer
Mitochondria participate in varieties of cellular events. It is widely accepted that human mitochondrial genome encodes 13 proteins, 2 rRNAs, and 22 tRNAs. Gene variation derived from human nuclear genome cannot completely explain mitochondrial diseases.
Liu, Donghong, Zhou, Xinyu, He, Yida, Zhao, Jun   +3 more
openaire   +2 more sources

circRNA meets gene amplification [PDF]

Non-coding RNA Investigation, 2018
Lung cancer remains the most common cause of cancer related death among both males and females globally accounting for 1.69 million deaths in 2015 (1). Of the different types of lung cancer, lung adenocarcinoma (LAC) is the most common (2). Given the prevalence and lethality of lung cancer the need to elucidate the mechanisms of this disease and to ...
Nicholas, Manguso, Armando E, Giuliano, Hisashi, Tanaka   +2 more
openaire   +2 more sources

Extracellular Vesicles‐Based Biological Macromolecule Delivery Systems: Biogenesis, Characterization, and Emerging Clinical Applications

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are nanoscale membrane‐bound structures that play a pivotal role in intercellular communication by transporting bioactive molecules, including proteins, lipids, nucleic acids, and organelles, between cells. Originating from the endosomal pathway, EVs reflect the physiological and pathological status of their parent
Emine İncilay Torunoğlu, Zeynep Betül Sarı, Muhammed Emin Sarı, Erdi Can Aytar   +3 more
wiley   +1 more source