Results 91 to 100 of about 34,260 (269)

Orchestrating the metastatic symphony: the role of extracellular vesicles in the epithelial–mesenchymal transition and pulmonary niche formation of breast cancer

Biological Reviews, EarlyView.
ABSTRACT The complexity of breast cancer (BC) lung metastasis lies in the capacity of tumour cells to interact efficiently with distant organs to promote colonisation, a process that involves the sophisticated coordination of inherent cellular plasticity and the remodelling of the distant microenvironment.
Jian Lu, Reza Shirazi Nia, Junjie Sun, Chrysa Filippopoulou, Daniel De Vega, Pengtao Hu, Heng Liang, Hang Yao, Chaoyue Pan, Xiaoyan Wu, Xidong Gu, Xiaohong Xie, Georgios Giamas   +12 more
wiley   +1 more source

Invention of circRNA promoting RNA to specifically promote circRNA production

Nucleic Acids Research
Abstract CircRNA, an essential RNA molecule involved in various biological functions and diseases, often exhibits decreased expression in tumor tissues, playing a role as a tumor suppressor, and suggesting therapeutic potential for cancer. However, current methods for promoting circRNA production are limited.
Zhilin He, Haofei Ji, Bei Xia, Xiuen Cao, Ying Huang, Qubo Zhu   +5 more
openaire   +2 more sources

Role of non-coding RNAs in skin photoaging

Pifu-xingbing zhenliaoxue zazhi
Skin photoaging, a phenomenon of premature skin aging due to prolonged exposure to ultraviolet (UV) radiation, manifests as wrinkles, loss of skin elasticity, pigmentation disorders, and age spots.
HE Zezhi, CHEN Jiazhen, WU Hui, SHEN Haojia, LI Runxiang, ZHU Huilan   +5 more
doaj   +1 more source

Identification of a circRNA/miRNA/mRNA ceRNA Network as a Cell Cycle-Related Regulator for Chronic Sinusitis with Nasal Polyps

Journal of Inflammation Research, 2022
Qi Sun,1,2,* Zhen Liu,1,2,* Xiangya Xu,1,* Yujuan Yang,1,2 Xiao Han,1,2 Cai Wang,1– 3 Fei Song,1,2,4 Yakui Mou,1,2 Yumei Li,1,2 Xicheng Song1,2 1Department of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao ...
Sun Q, Liu Z, Xu X, Yang Y, Han X, Wang C, Song F, Mou Y, Li Y, Song X   +9 more
doaj  

Novel Organelle‐Based Intracellular Immunity With Mechanistic and Therapeutic Implications

Barrier Immunity, EarlyView.
A conceptual framework illustrating how PAMPs/DAMPs initiate barrier, innate, adaptive, and intracellular immune responses, with organelle‐based intracellular immunity serving as a central integrator linking metabolism, inflammatory signaling, and therapeutic interventions to restore immune homeostasis.
Keman Xu, Shih‐Yu Hung, Fatma Saaoud, Ying Shao, Yifan Lu, Juanjuan Liu, Bo Yuan, Haiyan Xiang, Hong Wang, Xiaofeng Yang   +9 more
wiley   +1 more source

Exosomal CircRNAs in Circulation Serve as Diagnostic Biomarkers for Acute Myocardial Infarction

Frontiers in Bioscience-Landmark
Background: The diagnostic potential of circular RNAs (circRNAs) in circulating exosomes for acute myocardial infarction (AMI) is not well understood, despite existing research indicating their role in cardiovascular diseases. This study aimed to clarify
Xiaoyan Liu, Yeping Zhang, Wen Yuan, Ruijuan Han, Jiuchang Zhong, Xinchun Yang, Meili Zheng, Boqia Xie   +7 more
doaj   +1 more source

Biogenesis, Functions, and Role of CircRNAs in Lung Cancer

Cancer Management and Research, 2021
Huanhuan Dong,* Junliang Zhou,* Yue Cheng, Meiqi Wang, Shuqing Wang, Hui Xu Department of Clinical Laboratory, Harbin Medical University Cancer Hospital, Harbin, 150081, People’s Republic of China*These authors contributed equally to this ...
Dong H, Zhou J, Cheng Y, Wang M, Wang S, Xu H   +5 more
doaj  

Crosstalk between m6A mRNAs and m6A circRNAs and the time-specific biogenesis of m6A circRNAs after OGD/R in primary neurons

Epigenetics, 2023
Cerebral ischaemiareperfusion injury is an important pathological process in nervous system diseases during which neurons undergo oxygenglucose deprivation and reoxygenation (OGD/R) injury.
Chi Zhang, Huan Jian, Shenghui Shang, Lu Lu, Yongfu Lou, Yi Kang, Hong Bai, Zheng Fu, Yigang Lv, Xiaohong Kong, Xueying Li, Shiqing Feng, Hengxing Zhou   +12 more
doaj   +1 more source

Transcriptomic signatures reveal systemic adaptations and immune modulation in response to training and competitive racing in horses

Equine Veterinary Journal, EarlyView.
Abstract Background The molecular mechanisms underlying adaptation to physical exertion and racing stress in horses remain incompletely understood. Peripheral blood transcriptomics offers a minimally invasive method to monitor systemic responses to exercise and identify biomarkers of adaptation or overload. Objectives To evaluate transcriptomic changes
Izabela Dąbrowska, Jowita Grzędzicka‐Agko, Paula Kiełbik, Michał Trela, Olga Witkowska‐Piłaszewicz   +4 more
wiley   +1 more source

Dysregulation of circRNA-0076906 and circRNA-0134944 is Correlated with Susceptibility to Osteoporosis and Osteoporotic Fracture in Postmenopausal Females from the Chinese Han Population

Pharmacogenomics and Personalized Medicine, 2023
Weijie Yang,* Wei Zhang,* Fengqian Li, Ning Xu, Ping Sun Department of Orthopedics, Shanghai Eighth People’s Hospital, Shanghai, 200235, People’s Republic of China*These authors contributed equally to this workCorrespondence: Ping Sun ...
Yang W, Zhang W, Li F, Xu N, Sun P
doaj