Results 151 to 160 of about 32,863 (251)

Conserved and Tissue‐Specific RNA and Protein Cargos of Small Extracellular Vesicles From 120 Tissue Sites Across 34 Organs in a Single Pig

Journal of Extracellular Vesicles, Volume 15, Issue 10, October 2026.
A whole‐body map of sEVs from a single pig, including 133 samples spanning 10 systems, revealed striking tissue‐specific heterogeneity in yield. Importantly, a conserved core cargo set comprising candidate sEV markers (ACTG1, CFL1, and ANXA2), RNA‐binding proteins, the let‐7 miRNA family, and ferritin genes was defined from 105,409 (88.6% full‐length ...
Naixiang Yu, Jinxiu Liu, Chenliang Lai, Siyi Liu, Jiacheng Wei, Jiahong Zhong, Sanya Xiong, Qingjie Zeng, Junwu Ma, Zhou Zhang, Zhiyan Zhang   +10 more
wiley   +1 more source

Extracellular Vesicle‐Encapsulated Small RNAs From Clostridium Butyricum Modulate Host Intestinal Lipid Metabolism

Journal of Extracellular Vesicles, Volume 15, Issue 10, October 2026.
Extracellular vesicles (EVs) derived from C. butyricum can enter intestinal epithelial cells and mediate the anti‐lipid absorption effects by delivering miRNA‐like RNAs (milRNAs), particularly milRNA‐3020179, which primarily targeted host genes majorly including PPARα. Deletion of milRNA‐3020179 in C. butyricum abolished its effects on lipid deposition
Hong Hu, Yiwen He, Jing Liang, Qi Han, Xuqing Liang, Guangtian Cao, Yulong Tang, Liuqin He, Yulong Yin, Xihong Zhou   +9 more
wiley   +1 more source

CircRNAs in the heart: bricks in Brunelleschi’s Dome [PDF]

Cardiovascular Research, 2020
Paula A da Costa Martins, Federica De Majo   +1 more
openaire   +3 more sources

MVB Maturation Responsive to KRASG12D/TP53R175H Co‐mutations Fuels Extracellular Vesicle‐hypersecretion Phenotype to Aggravate Lymphangiogenesis and Lymphatic Metastasis

Journal of Extracellular Vesicles, Volume 15, Issue 10, October 2026.
KRAS/TP53 co‐mutation specifically induces transcriptional upregulation of FUS, which mediates EVs‐circSCARNA10 secretion to anchor lymphatic endothelial cells via promoting VEGFR3 transcription, ultimately inducing lymphangiogenesis and LN metastasis of KRASG12D and TP53R175H co‐mutated PDAC.
Jiabin Yang, Yuming Luo, Yu Zhou, Mingjie An, Mingrui Pang, Zhihua Li, Qingyu Xie, Hanhao Zheng, Zhou Fang, Yao Kong, Chao Yu, Yan Lin, Dingwen Zhang, Bingxin Cao, Haoming Zhong, Changhao Chen, Rufu Chen   +16 more
wiley   +1 more source

CircRNA-derived pseudogenes [PDF]

Cell Research, 2016
Dong, Rui, Zhang, Xiao-Ou, Zhang, Yang, Ma, Xu-Kai, Chen, Ling-Ling, Yang, Li   +5 more
openaire   +2 more sources

Comparative analysis of bioinformatic tools to predict and quantify active circular RNAs during grape cluster development

Biologia Plantarum
Circular RNAs (circRNAs) are relatively new members of the RNA world and can contribute to crucial biological functions. CircRNAs have tissue-specific expression profiles depending on cell type and developmental stage.
S. Ranjbar, A. Emamjomeh, M. Ebrahimi, A. Ghorbani, E. Ebrahimie, Y. Shiri   +5 more
doaj   +1 more source

Extracellular Vesicles: Classification, Biological Functions, Diseases, and Therapeutic Opportunities

MedComm, Volume 7, Issue 10, October 2026.
• EV content maintains cellular homeostasis and is involved in several disease onset and progression. • miRNA export in EVs depends on: RNA‐binding proteins recognizing motif sequences and on epitranscriptomic modifications. • The disclosure of delivery mechanisms is crucial for developing personalized EV‐based therapeutic tools. ABSTRACT Extracellular
Sabrina Garbo, Francesco Marocco, Clemens Zwergel, Marco Tripodi, Cecilia Battistelli   +4 more
wiley   +1 more source

Myelination and Remyelination in Peripheral Nerve Injury: Mechanisms, Regulation, and Therapeutic Perspectives

MedComm, Volume 7, Issue 10, October 2026.
Peripheral nerve injury triggers axonal degeneration, myelin breakdown, and Schwann cell reprogramming. Remyelination requires reactivation of the SOX10–OCT6–KROX20/EGR2 transcriptional hierarchy, axonal NRG1–ErbB2/3 signaling, metabolic support, and coordinated immune regulation.
Li‐Xin Huang, Tao Sun, Yi‐Bo Zhao, Zhi‐Min Wu, Jun Sun, Ming‐Yang Li, Qing‐Yi Huo, Yun‐Mou Ou, Qing‐Tian Liang, Cong Ling, Bao‐Yu Zhang, Chuan Chen, Ying Guo, Hui Wang   +13 more
wiley   +1 more source

The genomic character and conservation of circRNAs.

, 2018
(A) Mean length distribution of upstream and downstream intron flanking circularized exons in Z.mays. Longer intron bracketing circularized exons was observed than the parent gene.
Yanfeng Zhu (6069461), Guanglin Li (709617), Hua Zhang (12549), Zhiqiang Hao (709613), Baihua Tang (6069458)   +4 more
core   +1 more source

CircRNA: Functions, Applications and Prospects

Biomolecules
Circular RNAs (circRNAs) represent a distinct class of covalently closed non-coding RNA molecules characterized by the absence of free 5′ and 3′ ends [...]
Fei Xu, Qing Xiao, William W. Du, Sheng Wang, Burton B. Yang   +4 more
openaire   +3 more sources