Results 131 to 140 of about 32,863 (251)

Circular RNAs in diabetes mellitus and its complications: a systematic review and in silico analyses

Endocrine Connections
Introduction: Circular RNAs (circRNAs) have garnered attention as potential biomarkers for diabetes mellitus (DM) and its complications due to their stability and presence in various tissues and plasma.
Cristine Dieter, Eliandra Girardi, Igor Araújo Vieira, Thayne Woycinck Kowalski, Giovanna Câmara Giudicelli, Natália Emerim Lemos, Daisy Crispim   +6 more
doaj   +1 more source

Understanding extracellular vesicle biology, isolation, and characterization: The theory of EV‐erything

Periodontology 2000, EarlyView.
Abstract Background Extracellular vesicles (EVs), especially exosomes, are nanoparticles increasingly recognized as key regulators of intercellular communication in both physiological and pathological aspects. Despite rapid progress, inconsistencies in nomenclature, isolation, and characterization continue to restrict translational advancement.
Paras Ahmad, Nima Farshidfar, Nathan E. Estrin, Yulan Wang, Yufeng Zhang, Anton Sculean, Richard J. Miron   +6 more
wiley   +1 more source

The novel roles of circRNAs in human cancer

, 2019
Covalently closed single-stranded circular RNAs (circRNAs) consist of introns or exons and are widely present in eukaryotic cells. CircRNAs generally have low expression levels and relatively stable structures compared with messenger RNAs (mRNAs), most ...
Qingfeng Shang, Renbing Jia, Shengfang Ge, Zhi Yang   +3 more
core   +1 more source

Research Progress of Circular RNA and Protein Ubiquitination Modification in Cancer

Zhongliu Fangzhi Yanjiu
Circular RNAs (circRNAs) are a class of noncoding RNA molecules with a covalently enclosed circular structure and are more stable than linear RNAs. CircRNAs possess unique characteristics and biological functions, playing key roles in the occurrence and ...
Qintian HUANG, Chengnong GUAN
doaj   +1 more source

Genome-wide identification of circular RNAs in tomato seeds in response to high temperature

Biologia Plantarum, 2019
Circular RNAs (circRNAs), an emerging class of non-coding RNAs, are abundant in eukaryotic transcriptomes. Seed germination is one of the most important stages in the entire life cycle of plants that can be slowed down or totally restrained by high ...
R. Zhou, X.Q. Yu, L.P. Xu, Y.L. Wang, L.P. Zhao, T.M. Zhao, W.G. Yu   +6 more
doaj   +1 more source

Understanding extracellular vesicles in antiaging

Periodontology 2000, EarlyView.
Abstract Background Aging is a multifactorial process marked by gradual cellular dysregulation, regulated by hallmarks, including genomic instability, mitochondrial dysregulation, and chronic inflammation. Extracellular vesicles (EVs), especially exosomes, have emerged as pivotal mediators of cell‐to‐cell communication with potential roles in both ...
Paras Ahmad, Nathan E. Estrin, Anton Sculean, Richard J. Miron   +3 more
wiley   +1 more source

Predicting circRNA subcellular localization by fusing circRNA sequence and network information

Scientific Reports
CircRNAs have attracted more and more attentions in recent years as they play important roles in many biological processes. It is essential for determining the functions of circRNAs. The subcellular localizations of circRNAs are deemed to be related to their functions. Thus, it is necessary to determine the subcellular localizations of circRNAs.
Lei, Chen, Jinghai, Hu, Bo, Zhou
openaire   +2 more sources

The role of extracellular vesicles in cell–cell crosstalk in cardiotoxicity

The Journal of Physiology, EarlyView.
Abstract figure legend Administration of a pharmacological agent can result in off‐target cardiotoxicity which can be driven by cell–cell crosstalk between healthy and dysfunctional cardiac cells. Extracellular vesicles (EVs) are lipid bilayer structures that can move biological cargo between cells, facilitating cell–cell crosstalk.
Gabriella Bachynskyj‐Bilas, Debbie J. Otto, Daniel Stratton, Katja Rietdorf, Daniel M. Johnson, Calum J. McMullen   +5 more
wiley   +1 more source

Identification of a Circular RNA as a Potential Diagnostic and Prognostic Biomarker in Breast Cancer Through Integrated Bioinformatic and Experimental Analyses

Analytical Science Advances, Volume 7, Issue 2, December 2026.
Forty circular RNAs were found to be significantly dysregulated in microarray datasets. Expression levels of hsa_circ_0000231 were significantly upregulated in breast cancer (BC) tissues, while hsa_circ_0011385 exhibited no significant difference in expression levels. This study also revealed that hsa_circ_0000231/hsa‐miR‐5683/CCNB1 regulatory axis may
MohamadReza Hashemi, Pejman Morovat, Azin Khoshghiafeh, Novin Nikbakhsh, Mohamadreza Ahmadifard   +4 more
wiley   +1 more source

HNRNPD regulates the biogenesis of circRNAs and the ratio of mRNAs to circRNAs for a set of genes

RNA Biology
Exonic circular RNAs (ecircRNAs) in animal cells are generated by backsplicing, and the biogenesis of ecircRNAs is regulated by an array of RNA binding proteins (RBPs). HNRNPD is a heterogeneous nuclear ribonucleoprotein family member with both cytoplasmic and nuclear roles, and whether HNRNPD regulates the biogenesis of circRNAs remains unknown.
Shuhui Chang, Yucong Wang, Xiaolin Wang, Hanyuan Liu, Tao Zhang, Yangge Zheng, Xueren Wang, Ge Shan, Liang Chen   +8 more
openaire   +3 more sources