Results 121 to 130 of about 31,091 (262)

Expanding roles of circRNAs in cardiovascular diseases

CircRNAs are a class of single-stranded RNAs characterized by covalently looped structures. Emerging advances have promoted our understanding of circRNA biogenesis, nuclear export, biological functions, and functional mechanisms.
Liang Chen, Xuelin Yao, Xu Liu
core   +1 more source

Global accumulation of circRNAs during aging in Caenorhabditis elegans

, 2018
Background Circular RNAs (CircRNAs) are a newly appreciated class of RNAs that lack free 5′ and 3′ ends, are expressed by the thousands in diverse forms of life, and are mostly of enigmatic function.
Cortes-Lopez, Mariela, Voda, A-I, Pedro Miura, Cooper, Daphne A., Gruner, HN, Gruner, MR, Alexandru-Ioan Voda, Miura, Pedro, Voda, Alexandru, Gruner, Hannah N., Cortés-López, M, Mariela Cortés-López, Hannah N. Gruner, Miura, P, Gruner, Matthew R., Van Der Linden, AM, van der Linden, Alexander M., Daphne A. Cooper, Voda, Alexandru-Ioan, Alexander M. van der Linden, Cooper, DA, Matthew R. Gruner   +21 more
core   +1 more source

Characteristics of altered circRNAs between CIH and control samples.

, 2023
(A) The cluster shaped bar diagram shows the chromosome distribution of dysregulated circRNAs. (B) The histogram shows the origination of circRNAs.
Qingshi Chen (14037195), Zhiyu Chen (669085), Dexin Liu (138735), Jiayu Lin (8572872), Lishuang Che (15295565)   +4 more
core   +1 more source

In Vitro Sperm–Epididymosomes Interaction Immediately Before Fertilization Changes Sperm Fertility Potential

Andrology, EarlyView.
ABSTRACT Background Sperm acquire fertility ability during epididymal maturation mainly in the epididymal caput and corpus, and once matured, are stored in the epididymal cauda. During storage, interactions with cauda epididymosomes (epEVs) may influence sperm fertility potential; however, the role of such interactions on sperm fertility remains ...
Maíra Bianchi Rodrigues Alves, Maria Alice de Almeida, Ana Beatriz Bossois Moura, Laura Gabrielli Haupenthal, Raissa Braido Rangel, Flávio Vieira Meirelles, Juliano Coelho da Silveira, Felipe Perecin   +7 more
wiley   +1 more source

A Highly Efficient Strategy for Overexpressing circRNAs

, 2018
Circular RNAs (circRNAs) constitute an emerging class of widespread, abundant, and evolutionarily conserved noncoding RNA. They play important and diverse roles in cell development, growth, and tumorigenesis, but functions of the majority of circRNAs ...
Simon J. Conn, Conn, V., Dawei Liu, Gregory J. Goodall, Vanessa Conn, Liu, D., Goodall, G.J., Conn, S.J.   +7 more
core   +1 more source

Top 10 differential circRNAs for prostate cancer.

, 2021
Top 10 differential circRNAs for prostate cancer.
Tao-Lin Xia (11790741), Liang Luo (425058), Lei-Lei Zhang (4348597), Wen Tao (848995), Liao-Yuan Li (2328004)   +4 more
core   +1 more source

Integrated Transcriptomic and Functional Analyses Reveal lncRNA‐miRNA‐mRNA Axis in AML Relapse After Allo‐HSCT

Cancer Science, EarlyView.
Transcriptomic profiling of CD34+ cells from AML patients relapsing after allo‐HSCT reveals lncRNA‐driven ceRNA networks, with the SNHG8‐miR‐625‐ZC3H13/15 axis identified as a key relapse‐promoting module through CRISPR screening and single‐cell perturbation.
Fei Zhao, Wenhao Wang, Hongye Gao, Ping Zhu, Weihua Zhai, Yi He, Aiming Pang, Sizhou Feng, Mingzhe Han, Lina Wu, Shukai Qiao, Lei Zhang, Erlie Jiang, Xiaolei Pei, Donglin Yang   +14 more
wiley   +1 more source

circMAN1A2 as an Isoform‐Resolved Circular RNA Hub in Cancer

Cancer Science, EarlyView.
circMAN1A2 as an isoform‐resolved circular RNA hub in cancer. circMAN1A2 is generated by back‐splicing of MAN1A2 pre‐mRNA, with alternative circularization producing multiple isoforms, including the predominant circMAN1A2(2–5). Its mechanistic interfaces include miRNA‐associated regulation, RBP binding/proteostasis control, BSJ‐mediated RNA–RNA pairing,
Hanyu Shang, Hui Wang, Yonghang Xu, Lingyun Geng, Yanqing Wang   +4 more
wiley   +1 more source

A Specific tRNA Half, 3'tiRNA‐GlyGCC, Regulates Hypoxic Pulmonary Artery Smooth Muscle Cell Proliferation via Myrf‐Mediated Endoplasmic Reticulum Stress

Cell Proliferation, EarlyView.
A schematic diagram illustrating how 3′tiRNA‐GlyGCC promotes the endoplasmic reticulum stress (ERS) and proliferation in hypoxic pulmonary artery smooth muscle cells (PASMCs) by inhibiting the expression of myelin regulatory factor (Myrf), ultimately leading to pulmonary hypertension (PH).
Lixin Zhang, Xiaoyu Guan, Xiangrui Zhu, Yingying Hao, Ya Xu, Hao Yuan, Danni Gao, Hongxia Du, Jiayu Li, Weiwei Cao, Cui Ma, Xiaoying Wang   +11 more
wiley   +1 more source

Genome-wide Identification and characterization of circular RNAs in the rice blast fungus Magnaporthe oryzae

Scientific Reports, 2018
Numerous circRNAs have been identified in different organisms, but little attention has been addressed on fungal circRNAs. Here, we identified a total of 8,848 circRNAs from the model plant pathogenic fungus M. oryzae. 5,840 circRNAs were identified from
Jialan Yuan, Zhao Wang, Junjie Xing, Qingyong Yang, Xiao-Lin Chen   +4 more
doaj   +1 more source