Results 101 to 110 of about 25,680 (233)

Circular RNAs in diabetes mellitus and its complications: a systematic review and in silico analyses

Endocrine Connections
Introduction: Circular RNAs (circRNAs) have garnered attention as potential biomarkers for diabetes mellitus (DM) and its complications due to their stability and presence in various tissues and plasma.
Cristine Dieter, Eliandra Girardi, Igor Araújo Vieira, Thayne Woycinck Kowalski, Giovanna Câmara Giudicelli, Natália Emerim Lemos, Daisy Crispim   +6 more
doaj   +1 more source

circMAN1A2 as an Isoform‐Resolved Circular RNA Hub in Cancer

Cancer Science, EarlyView.
circMAN1A2 as an isoform‐resolved circular RNA hub in cancer. circMAN1A2 is generated by back‐splicing of MAN1A2 pre‐mRNA, with alternative circularization producing multiple isoforms, including the predominant circMAN1A2(2–5). Its mechanistic interfaces include miRNA‐associated regulation, RBP binding/proteostasis control, BSJ‐mediated RNA–RNA pairing,
Hanyu Shang, Hui Wang, Yonghang Xu, Lingyun Geng, Yanqing Wang   +4 more
wiley   +1 more source

Research Progress of Circular RNA and Protein Ubiquitination Modification in Cancer

Zhongliu Fangzhi Yanjiu
Circular RNAs (circRNAs) are a class of noncoding RNA molecules with a covalently enclosed circular structure and are more stable than linear RNAs. CircRNAs possess unique characteristics and biological functions, playing key roles in the occurrence and ...
Qintian HUANG, Chengnong GUAN
doaj   +1 more source

Predicting circRNA subcellular localization by fusing circRNA sequence and network information

Scientific Reports
CircRNAs have attracted more and more attentions in recent years as they play important roles in many biological processes. It is essential for determining the functions of circRNAs. The subcellular localizations of circRNAs are deemed to be related to their functions. Thus, it is necessary to determine the subcellular localizations of circRNAs.
Lei, Chen, Jinghai, Hu, Bo, Zhou
openaire   +2 more sources

CircHECTD1 Promotes Cholangiocarcinoma Progression Through Interaction With SFPQ to Induce Autophagy

Cancer Science, EarlyView.
CircHECTD1 directly interacts with SFPQ to upregulate ATG12 expression, thereby activating autophagy and promoting cholangiocarcinoma progression. This study uncovers a noncanonical circRNA–RNA‐binding protein regulatory mechanism and provides a potential therapeutic target for cholangiocarcinoma.
Shouwen Zhao, Shanshan Jiang, Xutong Wang, Kai Cui, Zhilei Cao, Le Zhang, Zhiqiang Wei, Yuping Ma, Han Hao, Kunpeng Zhang, Jiamin Zhang, Tianyu Dong   +11 more
wiley   +1 more source

A Specific tRNA Half, 3'tiRNA‐GlyGCC, Regulates Hypoxic Pulmonary Artery Smooth Muscle Cell Proliferation via Myrf‐Mediated Endoplasmic Reticulum Stress

Cell Proliferation, EarlyView.
A schematic diagram illustrating how 3′tiRNA‐GlyGCC promotes the endoplasmic reticulum stress (ERS) and proliferation in hypoxic pulmonary artery smooth muscle cells (PASMCs) by inhibiting the expression of myelin regulatory factor (Myrf), ultimately leading to pulmonary hypertension (PH).
Lixin Zhang, Xiaoyu Guan, Xiangrui Zhu, Yingying Hao, Ya Xu, Hao Yuan, Danni Gao, Hongxia Du, Jiayu Li, Weiwei Cao, Cui Ma, Xiaoying Wang   +11 more
wiley   +1 more source

HNRNPD regulates the biogenesis of circRNAs and the ratio of mRNAs to circRNAs for a set of genes

RNA Biology
Exonic circular RNAs (ecircRNAs) in animal cells are generated by backsplicing, and the biogenesis of ecircRNAs is regulated by an array of RNA binding proteins (RBPs). HNRNPD is a heterogeneous nuclear ribonucleoprotein family member with both cytoplasmic and nuclear roles, and whether HNRNPD regulates the biogenesis of circRNAs remains unknown.
Shuhui Chang, Yucong Wang, Xiaolin Wang, Hanyuan Liu, Tao Zhang, Yangge Zheng, Xueren Wang, Ge Shan, Liang Chen   +8 more
openaire   +3 more sources

Integrated Engineering of CAR‐T Cells for Solid Tumours

Cell Proliferation, EarlyView.
Solid tumours pose multifactorial barriers including antigen heterogeneity, immunosuppressive microenvironment, and poor T‐cell trafficking, limiting CAR‐T efficacy compared to hematologic malignancies. Integrated engineering strategies are essential, combining logic‐gated receptors for precision, metabolic‐epigenetic reprogramming for resilience, and ...
Chao Yang, Tan Li, Ping He, Zhijie Zhao, Shenglong Li, Liming Wang   +5 more
wiley   +1 more source

Noncoding RNAs as novel diagnostic biomarkers for diabetic retinopathy: A systematic review and meta‐analysis

Journal of Diabetes Investigation, EarlyView.
The systematic review and meta‐analysis (Embase, PubMed, and Web of Science; up to August 2025) evaluated circulating noncoding RNAs (ncRNAs) as noninvasive early diagnostic biomarkers for diabetic retinopathy (DR). From 17 articles (24 studies, 1,983 DR patients vs 1,437 controls), a random‐effects model yielded pooled sensitivity of 0.81, specificity
Ting Zhang, Donghong Xu
wiley   +1 more source

Characterization of Immune-Related circRNAs and mRNAs in Human Chronic Atrophic Gastritis

Journal of Inflammation Research
Yang Chao,1 Xiya Jin,1 Rui Guo,2 Hongyu Zhang,2 Xueling Cui,3 Yan Qi2 1Department of Gastroendoscopy, China-Japan Union Hospital of Jilin University, Changchun, Jilin, People’s Republic of China; 2Department of Immunology, College of Basic Medical ...
Chao Y, Jin X, Guo R, Zhang H, Cui X, Qi Y   +5 more
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