Results 81 to 90 of about 31,091 (262)
The functions and clinical significance of circRNAs in hematological malignancies
Journal of Hematology & Oncology, 2020 With covalently closed circular structures, circular RNAs (circRNAs) were once misinterpreted as by-products of mRNA splicing. Being abundant, stable, highly conserved, and tissue-specific, circRNAs are recently identified as a type of regulatory RNAs ...
Xiangxiang Zhou +3 more
doaj +1 more source
Novel Organelle‐Based Intracellular Immunity With Mechanistic and Therapeutic Implications
Barrier Immunity, EarlyView.A conceptual framework illustrating how PAMPs/DAMPs initiate barrier, innate, adaptive, and intracellular immune responses, with organelle‐based intracellular immunity serving as a central integrator linking metabolism, inflammatory signaling, and therapeutic interventions to restore immune homeostasis.
Keman Xu +9 more
wiley +1 more source
circRNA meets gene amplification [PDF]
Non-coding RNA Investigation, 2018 Lung cancer remains the most common cause of cancer related death among both males and females globally accounting for 1.69 million deaths in 2015 (1). Of the different types of lung cancer, lung adenocarcinoma (LAC) is the most common (2). Given the prevalence and lethality of lung cancer the need to elucidate the mechanisms of this disease and to ...
Nicholas, Manguso +2 more
openaire +2 more sources
New Insights into the Roles of Yes-Associated Protein (YAP1) in Colorectal Cancer Development and Progression [PDF]
Iranian Journal of Colorectal Research, 2019 Yes-associated protein (YAP1), the downstream effector of the Hippo pathway, plays important roles in the regulation of tissue reconstruction,stem cell proliferation, and development of different cancers.
Fariba Dehghanian +3 more
doaj
Regulatory role of circular RNAs in the development of therapeutic resistance in the glioma: A double-edged sword [PDF]
Iranian Journal of Basic Medical SciencesGliomas are the most common lethal tumors of the brain associated with a poor prognosis and increased resistance to chemo-radiotherapy. Circular RNAs (circRNAs), newly identified noncoding RNAs, have appeared as critical regulators of therapeutic ...
Negin Masoomabadi +3 more
doaj +1 more source
Identification and qRT-PCR validation of differential circRNAs.
, 2017 (A) There were 88 significantly upregulated circRNAs in PTC tumors versus normal thyroid tissue. There were 129 significantly upregulated circRNAs in PTC tumors versus benign thyroid lesions.
Lixin Shi (577302) +5 more
core +1 more source
Equine Veterinary Journal, EarlyView.Abstract Background The molecular mechanisms underlying adaptation to physical exertion and racing stress in horses remain incompletely understood. Peripheral blood transcriptomics offers a minimally invasive method to monitor systemic responses to exercise and identify biomarkers of adaptation or overload. Objectives To evaluate transcriptomic changes
Izabela Dąbrowska +4 more
wiley +1 more source
Comprehensive Characterization of Androgen-Responsive circRNAs in Prostate Cancer
, 2021 The androgen receptor (AR) signaling pathway plays an important role in the initiation and progression of prostate cancer. Circular RNAs (circRNAs), the novel noncoding RNAs without 5′ to 3′ polarity or 3′ poly (A), play an important role in multiple ...
Dujian Li +8 more
core +1 more source
Head &Neck, EarlyView.ABSTRACT Background Tumor cells adapt to hypoxia by releasing hiTDExs enriched with bioactive molecules that modulate endothelial behavior and promote tumor progression. This study aimed to characterize how hypoxia‐induced HNSCC exosomes reshape the endothelial secretome and contribute to metastatic potential.
Ozel Capik +6 more
wiley +1 more source
Length distribution of pear circRNAs.
, 2018 Length distribution of pear circRNAs.
Youhong Chang (113440) +6 more
core +1 more source