Results 81 to 90 of about 32,863 (251)

New Insights into the Roles of Yes-Associated Protein (YAP1) in Colorectal Cancer Development and Progression [PDF]

Iranian Journal of Colorectal Research, 2019
Yes-associated protein (YAP1), the downstream effector of the Hippo pathway, plays important roles in the regulation of tissue reconstruction,stem cell proliferation, and development of different cancers.
Fariba Dehghanian, Zahra Azhir, Atefeh Akbari, Zohreh Hojati   +3 more
doaj  

Regulatory role of circular RNAs in the development of therapeutic resistance in the glioma: A double-edged sword [PDF]

Iranian Journal of Basic Medical Sciences
Gliomas are the most common lethal tumors of the brain associated with a poor prognosis and increased resistance to chemo-radiotherapy. Circular RNAs (circRNAs), newly identified noncoding RNAs, have appeared as critical regulators of therapeutic ...
Negin Masoomabadi, Ali Gorji, Tahereh Ghadiri, Safieh Ebrahimi   +3 more
doaj   +1 more source

Engineering mRNA‐LNP Medicines for the Ageing Brain: Opportunities and Challenges for Neurodegenerative Diseases

Exploration, EarlyView.
This review highlights recent advances in engineering messenger RNA (mRNA)‐lipid nanoparticles (LNPs) to cross the ageing blood–brain barrier and target neurodegenerative diseases. It outlines design principles, delivery routes, and translational challenges, charting a roadmap towards clinical application of mRNA‐LNP therapeutics for neurodegenerative ...
Abdel Ali Belaidi, Denzil L. Furtado, Francesca Alves, Rebecca M. Nisbet, Scott Ayton, Ashley I. Bush   +5 more
wiley   +1 more source

The functions and clinical significance of circRNAs in hematological malignancies

Journal of Hematology & Oncology, 2020
With covalently closed circular structures, circular RNAs (circRNAs) were once misinterpreted as by-products of mRNA splicing. Being abundant, stable, highly conserved, and tissue-specific, circRNAs are recently identified as a type of regulatory RNAs ...
Xiangxiang Zhou, Linquan Zhan, Kai Huang, Xin Wang   +3 more
doaj   +1 more source

Global accumulation of circRNAs during aging in Caenorhabditis elegans [PDF]

, 2018
Background Circular RNAs (CircRNAs) are a newly appreciated class of RNAs that lack free 5′ and 3′ ends, are expressed by the thousands in diverse forms of life, and are mostly of enigmatic function.
Cortes-Lopez, Mariela, Voda, A-I, Pedro Miura, Cooper, Daphne A., Gruner, HN, Gruner, MR, Alexandru-Ioan Voda, Miura, Pedro, Voda, Alexandru, Gruner, Hannah N., Cortés-López, M, Mariela Cortés-López, Hannah N. Gruner, Miura, P, Gruner, Matthew R., Van Der Linden, AM, van der Linden, Alexander M., Daphne A. Cooper, Voda, Alexandru-Ioan, Alexander M. van der Linden, Cooper, DA, Matthew R. Gruner   +21 more
core   +1 more source

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

Identification and characterization of circRNAs in soybean roots.

, 2020
(A) Histogram of circRNAs identified in each sample under different P levels. (B) Numbers of circRNAs in each type. (C) Numbers of circRNAs from different chromosomes.
Kaiye Yu (5690612), Haiyan Lü (5690600), Xiangqian Zhang (3749950), Chongyuan Sun (8339037), Xiaoqian Liu (154284), Dan Zhang (51283), Lingling Lv (5690615), Jinyu Zhang (310913), Huanqing Xu (8339040), Xiaohui He (1847254)   +9 more
core   +1 more source

Expression profiles of circular RNAs in sheep skeletal muscle [PDF]

Asian-Australasian Journal of Animal Sciences, 2018
Objective Circular RNAs (circRNAs) are a newfound class of non-coding RNA in animals and plants. Recent studies have revealed that circRNAs play important roles in cell proliferation, differentiation, autophagy and apoptosis during development.
Yang Cao, Shuang You, Yang Yao, Zhi-Jin Liu, Wureli Hazi, Cun-Yuan Li, Xiang-Yu Zhang, Xiao-Xu Hou, Jun-Chang Wei, Xiao-Yue Li, Da-Wei Wang, Chuang-Fu Chen, Yun-Feng Zhang, Wei Ni, Sheng-Wei Hu   +14 more
doaj   +1 more source

Deciphering transcriptome complexity via long‐read sequencing

iMeta, EarlyView.
Long‐read sequencing is transforming transcriptomics from gene‐level quantification to isoform‐resolved interpretation by directly resolving full‐length transcript structures, transcription in repetitive regions, and linked molecular features. This review provides an end‐to‐end roadmap covering sequencing platforms, library preparation strategies ...
Chuwen Xu, Jia Li, Chenxi Yin, Keying Li, Tian Wang, Shiwen Gao, Yue Yu, Cheng Chang, Ye Wang, Guoqing Tong, Liang Gong, Wen Hu, Guoliang Chai, Yilai Han, Qian Qin, Suoqin Jin, Xiufen Zou, Bo Li, Tianyuan Zhang, Ana Conesa, Yunhao Wang, Dingjie Wang   +21 more
wiley   +1 more source

Identification and qRT-PCR validation of differential circRNAs.

, 2017
(A) There were 88 significantly upregulated circRNAs in PTC tumors versus normal thyroid tissue. There were 129 significantly upregulated circRNAs in PTC tumors versus benign thyroid lesions.
Lixin Shi (577302), Qiao Zhang (138583), Hui Ye (164331), Nianchun Peng (3833131), Ying Hu (14950), Nanpeng Wang (3833128)   +5 more
core   +1 more source