Results 61 to 70 of about 31,091 (262)
Endogenous Engineering Reprograms Extracellular Vesicles for Enhanced Therapeutic Function
Advanced Science, EarlyView.This review explains how Extracellular vesicles‐producing cells can be endogenously engineered to load therapeutic proteins and nucleic acids. We summarize physiological and genetic strategies that harness native sorting pathways for selective cargo loading.
Jinghui Wang +10 more
wiley +1 more source
The Cellular and Viral circRNAome Induced by Respiratory Syncytial Virus Infection
mBio, 2021 Circular RNAs (circRNAs) are a new class of noncoding RNAs that have gained increased attention. DNA virus infections have been reported to induce modifications in cellular circRNA transcriptomes and express viral circRNAs.
Wenxia Yao +10 more
doaj +1 more source
Enhanced Intracellular Stability and Translation Efficiency of mRNA Drugs by a 2‐arm mRNA Platform
Advanced Science, EarlyView.We constructed a 2‐arm mRNA, characterized by a unique topology formed through the dimerization of two mRNA 3’ tails. The 2‐arm mRNA improves 3’ tail stability and resistance to nuclease degradation, resulting in an intracellular half‐life of up to 65 h. This method substantially enhances the translation capacity of mRNA drugs.
Xucong Teng +5 more
wiley +1 more source
Plasma circRNAs as Biomarkers in Cancer
Cancer Management and Research, 2021 The incidence and mortality of cancer are increasing each year. At present, the sensitivity and specificity of the blood biomarkers that were used in clinical practice are low, which make the detection rate of cancer decrease. With advances in bioinformatics and technology, some non-coding RNA as biomarkers can be easily detected through some ...
Qian Zhou +5 more
openaire +4 more sources
Circular RNA circ-Olfm1 induces progression of Alzheimer’s disease by regulating FOXO3a
陆军军医大学学报Objective To investigate the role of circular RNAs （circRNA） in Alzheimer’s disease （AD） and its potential mechanism. Methods Six-month-old APP/PS1 mouse model of AD and wild type (WT) mice were subjected and then randomly divided into WT group, WT ...
YANG Hongyan, LIAO Qirong, HOU Mingliang
doaj +1 more source
Microarray expression profile of exosomal circRNAs
, 2022 Interaction between the differential circRNAs and miRNAs were theoretically predicted by TargetScan and miRanda algorithm (http://www.microrna.org/microrna/home.do/). With the database, we searched miRNA response elements (MREs) on circRNAs, and selected
Yan-Hua Sha (12992331)
core +1 more source
NAT10‐Mediated ac4C Modification of circANKRD12 Reprograms the Tumor Microenvironment
Advanced Science, EarlyView.NAT10‐dependent acetylation of circANKRD12 drives translation of the circANKRD12_354aa protein, which binds HDAC2 to stabilize c‐Myc via deubiquitination, promoting multiple myeloma (MM) cell proliferation. Concurrently, the circANKRD12‐HDAC2 axis suppresses H3ac‐mediated transcription of IFN‐γ, TNF‐α, and GZMB in NK cells, leading to NK cell ...
Jiale Zhang +8 more
wiley +1 more source
The Secret Garden of Neuronal circRNAs [PDF]
Cells, 2020 High-throughput transcriptomic profiling approaches have revealed that circular RNAs (circRNAs) are important transcriptional gene products, identified across a broad range of organisms throughout the eukaryotic tree of life. In the nervous system, they are particularly abundant, developmentally regulated, region-specific, and enriched in genes for ...
Gasparini S. +3 more
openaire +4 more sources
Identification of tomato circular RNAs in response to Botrytis cinerea
Horticultural ScienceBotrytis cinerea is one of the main pathogens that harm the tomato yield and cause huge economic losses worldwide. Studies of circRNAs in response to the stress caused by pathogens have received more and more attention in tomato and other model crops. In
Linlin Li +6 more
doaj +1 more source
The Diagnostic Value of Serum Exosomal Has_circ_0000615 for Breast Cancer Patients
International Journal of General Medicine, 2021 Jiani Liu,1,2 Xinyu Peng,3 Yinfeng Liu,2 Ran Hao,4 Rumeng Zhao,4 Lei Zhang,4 Fuqing Zhao,4 Qi Liu,4 Yunjiang Liu,1 Yixin Qi1 1Department of Breast Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050000, Hebei, People’s Republic of
Liu J +9 more
doaj