Results 61 to 70 of about 32,863 (251)
The Cellular and Viral circRNAome Induced by Respiratory Syncytial Virus Infection
mBio, 2021 Circular RNAs (circRNAs) are a new class of noncoding RNAs that have gained increased attention. DNA virus infections have been reported to induce modifications in cellular circRNA transcriptomes and express viral circRNAs.
Wenxia Yao +10 more
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Deltacoronavirus Modulates circRNA cGLIS3 Metabolism to Evade Host Antiviral Response
Advanced Science, EarlyView.This study reveals that both deltacoronavirus nucleocapsid protein and host RNA binding protein IGF2BP2 promote circular RNA GLIS3 (cGLIS3) biogenesis by binding to GLIS3 pre‐mRNA. The m6A modification‐mediated cGLIS3‐IGF2BP2 interaction weakens RNase L‐mediated degradation of cGLIS3 while facilitates a ubiquitin‐dependent degradation of IGF2BP2, thus ...
Liuyang Du +10 more
wiley +1 more source
Circular RNA circ-Olfm1 induces progression of Alzheimer’s disease by regulating FOXO3a
陆军军医大学学报Objective To investigate the role of circular RNAs （circRNA） in Alzheimer’s disease （AD） and its potential mechanism. Methods Six-month-old APP/PS1 mouse model of AD and wild type (WT) mice were subjected and then randomly divided into WT group, WT ...
YANG Hongyan, LIAO Qirong, HOU Mingliang
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Advanced Science, EarlyView.ESCC‐derived exosomal circAP2B1 promotes tumor progression by reprogramming mitochondrial metabolism via the ESRRA/KPNA1/MFN2 axis to induce M2 polarization of macrophages. ABSTRACT Esophageal squamous cell carcinoma (ESCC) remodels the immunosuppressive tumor microenvironment via exosome‐mediated intercellular communication.
Yiru Wang +5 more
wiley +1 more source
Identification of tomato circular RNAs in response to Botrytis cinerea
Horticultural ScienceBotrytis cinerea is one of the main pathogens that harm the tomato yield and cause huge economic losses worldwide. Studies of circRNAs in response to the stress caused by pathogens have received more and more attention in tomato and other model crops. In
Linlin Li +6 more
doaj +1 more source
The Diagnostic Value of Serum Exosomal Has_circ_0000615 for Breast Cancer Patients
International Journal of General Medicine, 2021 Jiani Liu,1,2 Xinyu Peng,3 Yinfeng Liu,2 Ran Hao,4 Rumeng Zhao,4 Lei Zhang,4 Fuqing Zhao,4 Qi Liu,4 Yunjiang Liu,1 Yixin Qi1 1Department of Breast Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050000, Hebei, People’s Republic of
Liu J +9 more
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The biogenesis, function and clinical significance of circular RNAs in breast cancer
Cancer Biology & Medicine, 2022 Circular RNAs (circRNAs) are noncoding RNAs that form covalently closed loop structures. CircRNAs are dysregulated in cancer and play key roles in tumorigenesis, diagnosis, and tumor therapy.
Yan Zeng +6 more
doaj +1 more source
Advanced Science, EarlyView.CircZNF148 stabilizes HK1 through deubiquitinase recruitment, thereby enhancing glycolysis and lactate production. Elevated lactate promotes PD‑L1 lactylation and membrane accumulation while suppressing CD8+ T‐cell cytotoxicity, collectively facilitating immune evasion and malignant progression in TNBC.
Yuhan Jin +17 more
wiley +1 more source
CircRNAs in osteoarthritis: research status and prospect [PDF]
, 2023 Osteoarthritis (OA) is the most common joint disease globally, and its progression is irreversible. The mechanism of osteoarthritis is not fully understood.
Zhuang Li, Jun Lu
core +1 more source
Functions and clinical significance of circular RNAs in acute myeloid leukemia
Frontiers in Pharmacology, 2022 Circular RNAs (circRNAs) are a class of covalently closed single-stranded RNA molecules. Four types of circRNAs have been reported in animal cells, and they have typical characteristics in their biogenesis, nuclear export and degradation. Advances in our
Min Zhou +5 more
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