Results 51 to 60 of about 32,863 (251)
Impact of exosomal and cell-free circRNAs on cancer drug resistance [PDF]
ExRNACancer is the most lethal disease in humans. Despite substantial advancements in cancer therapy during the last decades, the effectiveness of chemotherapeutic agents is limited since many patients develop drug resistance.
Heidi Schwarzenbach
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The Potential Regulatory Roles of Circular RNAs in Tumor Immunology and Immunotherapy
Frontiers in Immunology, 2021 Circular RNAs (circRNAs) are covalently closed RNA molecules in eukaryotes with features of high stability, tissue-specific and cell-specific expression. According to their biogenesis, circRNAs are mainly classified into five types, i.e. exonic circRNAs (
Zhixiao Fang +3 more
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Roles of circRNAs in the tumour microenvironment [PDF]
Molecular Cancer, 2020 Abstract The tumour microenvironment (TME) constitutes the area surrounding the tumour during its development and has been demonstrated to play roles in cancer-related diseases through crosstalk with tumour cells. Circular RNAs (circRNAs) are a subpopulation of endogenous noncoding RNAs (ncRNAs) that are ubiquitously expressed in ...
Qiuge Zhang +7 more
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Clinical and Experimental Hypertension, 2017 Objectives: CircRNAs, a novel class of noncoding RNAs, have been reported in many diseases. However, their role in hypertension remains unclear. Here, we aimed to determine the circRNA expression profile in hypertension patients and further construct a ...
Na Wu, Ling Jin, Jun Cai
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Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA
FEBS Open Bio, EarlyView.Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley +1 more source
Expression pattern of circRNAs.
, 2018 (A) Expression level of circRNAs in different scopes. CircRNAs were usually expressed at lower levels, which may explain their difficult detection because they lack a poly(A) tail. ctrl and dr indicate control and drought, respectively. (B) The degree of
Yanfeng Zhu (6069461) +4 more
core +1 more source
Plasma circRNAs as Biomarkers in Cancer
Cancer Management and Research, 2021 The incidence and mortality of cancer are increasing each year. At present, the sensitivity and specificity of the blood biomarkers that were used in clinical practice are low, which make the detection rate of cancer decrease. With advances in bioinformatics and technology, some non-coding RNA as biomarkers can be easily detected through some ...
Qian Zhou +5 more
openaire +4 more sources
Advanced Materials for Biologics Delivery to Brain Tumors
Advanced Materials, EarlyView.Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng +4 more
wiley +1 more source
The Application of Clinical Genetics, 2022 Safaa I Tayel,1 Shimaa E Soliman,1 Iman A Ahmedy,2 Mohamed Abdelhafez,3 Aly M Elkholy,3 Amira Hegazy,4 Nashwa M Muharram1 1Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Menoufia University, Shebin El-Kom, 32511, Egypt ...
Tayel SI +6 more
doaj
Advanced Science, EarlyView.The present study shows that Nrf2 directly binds to the Gm26550 promoter, thereby activating Gm26550 transcription and increasing its expression. Mechanistically, Gm26550 promotes IGF1 expression by functionally antagonizing miR‐26a‐5p‐mediated repression and sequestering the RBP KHSRP, thereby enhancing hippocampal neuronal synaptic plasticity and ...
Hongfang Wang +12 more
wiley +1 more source