Results 51 to 60 of about 31,091 (262)
Roles of circRNAs in the tumour microenvironment [PDF]
Molecular Cancer, 2020 Abstract The tumour microenvironment (TME) constitutes the area surrounding the tumour during its development and has been demonstrated to play roles in cancer-related diseases through crosstalk with tumour cells. Circular RNAs (circRNAs) are a subpopulation of endogenous noncoding RNAs (ncRNAs) that are ubiquitously expressed in ...
Qiuge Zhang +7 more
openaire +3 more sources
Impact of exosomal and cell-free circRNAs on cancer drug resistance [PDF]
ExRNACancer is the most lethal disease in humans. Despite substantial advancements in cancer therapy during the last decades, the effectiveness of chemotherapeutic agents is limited since many patients develop drug resistance.
Heidi Schwarzenbach
doaj +1 more source
CircRNAS expression profile in colorectal cancer
, 2022 Os RNAs circulares (circRNAs) são uma nova classe de RNA que forma laços (loops) contínuos fechados covalentemente. Como os RNAs longos e não codificadores, as funções efetivas dos circRNAs dependem principalmente das características de suas sequências e
Freitas, Vanessa Galdeno
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The Potential Regulatory Roles of Circular RNAs in Tumor Immunology and Immunotherapy
Frontiers in Immunology, 2021 Circular RNAs (circRNAs) are covalently closed RNA molecules in eukaryotes with features of high stability, tissue-specific and cell-specific expression. According to their biogenesis, circRNAs are mainly classified into five types, i.e. exonic circRNAs (
Zhixiao Fang +3 more
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Clinical and Experimental Hypertension, 2017 Objectives: CircRNAs, a novel class of noncoding RNAs, have been reported in many diseases. However, their role in hypertension remains unclear. Here, we aimed to determine the circRNA expression profile in hypertension patients and further construct a ...
Na Wu, Ling Jin, Jun Cai
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Expression pattern of circRNAs.
, 2018 (A) Expression level of circRNAs in different scopes. CircRNAs were usually expressed at lower levels, which may explain their difficult detection because they lack a poly(A) tail. ctrl and dr indicate control and drought, respectively. (B) The degree of
Yanfeng Zhu (6069461) +4 more
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Advanced Science, EarlyView.Model of circNrip1 (cNrip1) upregulation driving neuropathic pain mechanisms. After peripheral nerve injury, increased FUS triggers the formation and upregulation of cNrip1 in injured DRG neurons. Upregulated cNrip1 recruits SYNCRIP to the 3′‐UTR of Tlr2 mRNA by binding to both, thereby promoting SYNCRIP‐triggered Tlr2 mRNA stability and increasing ...
Xiaozhou Feng +14 more
wiley +1 more source
Advanced Science, EarlyView.sEVs‐circ6718 serves as a promising serum biomarker for gastric cancer early diagnosis and prognosis, promoting malignant transformation in gastric cancer cells and GC‑MSC differentiation into CAFs. sEVs‑circ6718 holds potential as a biomarker for the early diagnosis and prognostic assessment of gastric cancer.
Fan Zhang +7 more
wiley +1 more source
The Application of Clinical Genetics, 2022 Safaa I Tayel,1 Shimaa E Soliman,1 Iman A Ahmedy,2 Mohamed Abdelhafez,3 Aly M Elkholy,3 Amira Hegazy,4 Nashwa M Muharram1 1Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Menoufia University, Shebin El-Kom, 32511, Egypt ...
Tayel SI +6 more
doaj
CircRNAs in osteoarthritis: research status and prospect [PDF]
, 2023 Osteoarthritis (OA) is the most common joint disease globally, and its progression is irreversible. The mechanism of osteoarthritis is not fully understood.
Zhuang Li, Jun Lu
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