Results 41 to 50 of about 25,680 (233)

The Potential Regulatory Roles of Circular RNAs in Tumor Immunology and Immunotherapy

Frontiers in Immunology, 2021
Circular RNAs (circRNAs) are covalently closed RNA molecules in eukaryotes with features of high stability, tissue-specific and cell-specific expression. According to their biogenesis, circRNAs are mainly classified into five types, i.e. exonic circRNAs (
Zhixiao Fang, Chunjie Jiang, Chunjie Jiang, Shengli Li   +3 more
doaj   +1 more source

Profiling and bioinformatics analyses reveal differential circular RNA expression in hypertensive patients

Clinical and Experimental Hypertension, 2017
Objectives: CircRNAs, a novel class of noncoding RNAs, have been reported in many diseases. However, their role in hypertension remains unclear. Here, we aimed to determine the circRNA expression profile in hypertension patients and further construct a ...
Na Wu, Ling Jin, Jun Cai
doaj   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Nanomaterial Strategies for Pulmonary Delivery of Immunotherapeutics in Lung Cancer Treatment

Advanced Healthcare Materials, EarlyView.
Inhalable immunotherapeutic nanomedicines enable organ‐selective immune modulation by overcoming pulmonary delivery barriers and concentrating therapy within lung tumors. This Review defines how nanomaterial properties govern airway deposition, retention, cellular partitioning, and immune activation across vaccines, checkpoint blockade, STING agonists,
Han Zhang, Wei Tang
wiley   +1 more source

Deregulation of CircANXA2, Circ0075001, and CircFBXW7 Gene Expressions and Their Predictive Value in Egyptian Acute Myeloid Leukemia Patients

The Application of Clinical Genetics, 2022
Safaa I Tayel,1 Shimaa E Soliman,1 Iman A Ahmedy,2 Mohamed Abdelhafez,3 Aly M Elkholy,3 Amira Hegazy,4 Nashwa M Muharram1 1Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Menoufia University, Shebin El-Kom, 32511, Egypt ...
Tayel SI, Soliman SE, Ahmedy IA, Abdelhafez M, Elkholy AM, Hegazy A, Muharram NM   +6 more
doaj  

Mitigating Cancer Therapy–Related Cognitive Impairment by Targeted Activation of Undruggable Phosphatase

Advanced Science, EarlyView.
An RVG‑engineered exosomal saRNA delivery system (RVG‑EVs‑saPtpro) effectively targets and activates hippocampal PTPRO, functioning as a “molecular brake” to alleviate cancer therapy‑related cognitive impairment (CTRCI) by enhancing neuronal survival, neurogenesis, and synaptic plasticity.
Zhimeng Yao, Yuhua Meng, Huanyi Li, Yinhui Jiang, Xiaona Lin, Mengyuan Hu, Qing Liu, Xiaofu Qiu, Hongzheng Ren, Yunlong Pan, Bin Pan, Zexiong Guo, Shuyao Zhang, Dianzheng Zhang, Li Yang, Shegan Gao, Weijing Deng, Jianfan Chen, Hao Zhang   +18 more
wiley   +1 more source

The Cellular and Viral circRNAome Induced by Respiratory Syncytial Virus Infection

mBio, 2021
Circular RNAs (circRNAs) are a new class of noncoding RNAs that have gained increased attention. DNA virus infections have been reported to induce modifications in cellular circRNA transcriptomes and express viral circRNAs.
Wenxia Yao, Jinghui Pan, Zhaoyu Liu, Zhijie Dong, Min Liang, Shu Xia, Yao Xiao, Xiaodan Cai, Tao Peng, Xinke Zhou, Hua Cai   +10 more
doaj   +1 more source

Ovarian Cancer Diagnosis and Chemoresistance Prediction Model Based on cfRNA Molecular Signature

Advanced Science, EarlyView.
A deep learning model analyzes cfRNA profiles extracted from the blood of OVCA patients. This innovative approach distinguishes OVCA from healthy controls with high accuracy. Crucially, it reliably predicts patient response to chemotherapy (sensitive versus resistant subgroups).
Qinhao Guo, Yangyang Zhang, Yongcheng Jin, Siwei Deng, Yongqi Chen, Zheng Feng, Hao Wen, Liu Wang, Yilin Li, Fanghong Ou, Yong Shen, Haiming Li, Tianyao Zhou, Xingzhu Ju, Xiaohua Wu   +14 more
wiley   +1 more source

Circular RNA circ-Olfm1 induces progression of Alzheimer’s disease by regulating FOXO3a

陆军军医大学学报
Objective‍　‍To investigate the role of circular RNAs （circRNA） in Alzheimer’s disease （AD） and its potential mechanism. Methods‍　‍Six-month-old APP/PS1 mouse model of AD and wild type (WT) mice were subjected and then randomly divided into WT group, WT ...
YANG Hongyan, LIAO Qirong, HOU Mingliang
doaj   +1 more source

Plasma circRNAs as Biomarkers in Cancer

Cancer Management and Research, 2021
The incidence and mortality of cancer are increasing each year. At present, the sensitivity and specificity of the blood biomarkers that were used in clinical practice are low, which make the detection rate of cancer decrease. With advances in bioinformatics and technology, some non-coding RNA as biomarkers can be easily detected through some ...
Qian Zhou, Lin-Ling Ju, Xiang Ji, Ya-Li Cao, Jian-Guo Shao, Lin Chen   +5 more
openaire   +4 more sources