Results 21 to 30 of about 31,091 (262)
RNA Biology, 2016 Circular RNAs (circRNAs) are highly abundant and evolutionarily conserved non-coding RNAs produced by circularization of specific exons. Since their re-discovery as potential regulators of gene expression, thousands of circRNAs were detected in different tissues and cell types across most organisms.
Mor, Hanan +2 more
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Cancer Management and Research, 2021 The roles of circRNAs in neuroblastoma (NB) are unclear. We used next-generation sequencing to detect the circRNA expression profiles in NB to identify the key circRNAs and analyzed the relationships between the circRNAs and clinical features.Five paired neuroblastoma tumor and adjacent normal fetal adrenal medulla samples were collected for high ...
Lin,Weihong +6 more
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Current Opinion in Genetics & Development, 2018 Exonic circular RNAs (circRNAs) are mostly generated from exons of protein-coding genes and, in many cases, are more abundant that the linear product from their hosting gene. Certain circRNAs are very abundant in the brain and in non-dividing cells; and many also show physiological-specific and tissue-specific expression.
Patop, Ines Lucia, Kadener, Sebastian
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The invasion of circRNAs [PDF]
RNA Biology, 2017 Single-stranded covalently closed circular RNA (circRNA) molecules come in many disguises, with different biogenesis mechanisms and functions.
Thomas B, Hansen, Jørgen, Kjems
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Characterizing viral circRNAs and their application in identifying circRNAs in viruses
Briefings in Bioinformatics, 2021 Abstract Circular RNAs (circRNAs) are non-coding RNAs with a special circular structure produced formed by the reverse splicing mechanism, which play an important role in a variety of biological activities. Viruses can encode circRNA, and viral circRNAs have been found in multiple single-stranded and double-stranded viruses. However, the
Mengting Niu +3 more
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Nature Reviews Molecular Cell Biology, 2020 Increased expression of the circular RNA generated by the sulfateless gene (circSfl), and of the protein it encodes, can extend the lifespan of flies.
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LncRNAs and CircRNAs in cancer
MedComm, 2022 AbstractIt is well known that noncoding RNAs (ncRNAs) cannot encode proteins, but they can play important regulatory roles in tumors by combining with proteins, RNAs, and DNAs. As more and more studies reveal the important roles and underlying mechanisms of long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs) in cancer, their huge application ...
Xin Yin +5 more
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circRNA-sponging: a pipeline for extensive analysis of circRNA expression and their role in miRNA sponging [PDF]
Bioinformatics Advances, 2023 ABSTRACT Motivation Circular RNAs (circRNAs) are long non-coding RNAs (lncRNAs) often associated with diseases and considered potential biomarkers for diagnosis and treatment. Among other functions, circRNAs have been shown to act as microRNA (miRNA) sponges, preventing the role of miRNAs that ...
Markus Hoffmann +10 more
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CircRNA expression profile and circRNA-miRNA-mRNA crosstalk in allergic rhinitis [PDF]
World Allergy Organization Journal, 2020 Circular RNAs (circRNAs) are involved in inflammation; however, their role in allergic rhinitis (AR) remains unclear. In this study, we analyzed circRNA expression and identified a circRNA-miRNA-mRNA network through which circRNAs regulate AR pathogenesis.We analyzed circRNA, miRNA, and mRNA expression profiles in the nasal mucosa by high-throughput ...
Chang-Yu Qiu +7 more
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circRNAs in drug resistance of breast cancer [PDF]
, 2022 : Breast cancer (BC) is the most common heterogeneous disease in women and one of the leading causes of cancer-related death. Surgery, chemotherapy, radiotherapy, hormone, and targeted therapy are the gold standards for BC treatment.
ALIYAZICIOGLU,YUKSEL +5 more
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