Results 11 to 20 of about 36,533 (268)
From circRNAs to fusion circRNAs in hematological malignancies [PDF]
JCI Insight, 2021 Circular RNAs (circRNAs) represent a type of endogenous noncoding RNA generated by back-splicing events. Unlike the majority of RNAs, circRNAs are covalently closed, without a 5′ end or a 3′ poly(A) tail.
Loelia Babin +5 more
doaj +4 more sources
CircRNA Role and circRNA-Dependent Network (ceRNET) in Asthenozoospermia [PDF]
Frontiers in Endocrinology, 2020 The role of circRNA in reproduction is under investigation. CircRNAs are expressed in human testis, spermatozoa (SPZ), and seminal plasma. Their involvement in embryo development has also been suggested. Asthenozoospermia, a common cause of male infertility, is characterized by reduced or absent sperm motility in fresh ejaculate.
Francesco Manfrevola +8 more
openaire +3 more sources
Cancer Management and Research, 2021 The roles of circRNAs in neuroblastoma (NB) are unclear. We used next-generation sequencing to detect the circRNA expression profiles in NB to identify the key circRNAs and analyzed the relationships between the circRNAs and clinical features.Five paired neuroblastoma tumor and adjacent normal fetal adrenal medulla samples were collected for high ...
Lin,Weihong +6 more
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CircRNA May Not Be “Circular” [PDF]
Frontiers in Genetics, 2021 Circular RNA (circRNA) is a novel regulatory non-coding RNA and participates in diverse physiological and pathological processes. However, the structures and molecular mechanisms of circRNAs remain unclear. In this study, taking advantage of openly databases and bioinformatics analysis, we observed lots of internal complementary base-pairing sequences (
Handong Sun +14 more
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Current Opinion in Genetics & Development, 2018 Exonic circular RNAs (circRNAs) are mostly generated from exons of protein-coding genes and, in many cases, are more abundant that the linear product from their hosting gene. Certain circRNAs are very abundant in the brain and in non-dividing cells; and many also show physiological-specific and tissue-specific expression.
Patop, Ines Lucia, Kadener, Sebastian
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CircRNA expression profile and circRNA-miRNA-mRNA crosstalk in allergic rhinitis [PDF]
World Allergy Organization Journal, 2020 Circular RNAs (circRNAs) are involved in inflammation; however, their role in allergic rhinitis (AR) remains unclear. In this study, we analyzed circRNA expression and identified a circRNA-miRNA-mRNA network through which circRNAs regulate AR pathogenesis.We analyzed circRNA, miRNA, and mRNA expression profiles in the nasal mucosa by high-throughput ...
Chang-Yu Qiu +7 more
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NOVA2 regulates neural circRNA biogenesis [PDF]
Nucleic Acids Research, 2021 Abstract Circular RNAs (circRNAs) are highly expressed in the brain and their expression increases during neuronal differentiation. The factors regulating circRNAs in the developing mouse brain are unknown. NOVA1 and NOVA2 are neural-enriched RNA-binding proteins with well-characterized roles in alternative splicing.
David Knupp +4 more
openaire +3 more sources
CircRNAs: Insights into Gastric Cancer [PDF]
Gastrointestinal Tumors, 2021 <b><i>Background:</i></b> Gastric cancer (GC) is recorded as the fifth most common cancer globally. The classic resemblance of early symptoms of chronic gastritis including nausea, dysphagia, and dyspepsia with GC is the current challenge limiting the early diagnosis of GC. The current diagnostic procedures of GC are limited due
Sanjana, Rajgopal +2 more
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CircRNAs in Tumor Radioresistance
Biomolecules, 2022 Circular RNAs (circRNAs) are endogenous, non-coding RNAs, which are derived from host genes that are present in several species and can be involved in the progression of various diseases. circRNAs’ leading role is to act as RNA sponges. In recent years, the other roles of circRNAs have been discovered, such as regulating transcription and translation ...
Yining Gao +7 more
openaire +3 more sources
EVALUATION OF EXOSOME-DERIVED CircRNA EXPRESSION PATTERNS IN LUNG CANCER RADIOTHERAPY
Sabiad, 2022 Background: Radiotherapy is an effective method used in the treatment of lung cancer. However, it is very difficult to assess the clinical manifestations of radiotherapy at an early stage and the relevant criteria are very limited.
Saina Rahimi +6 more
doaj +1 more source