CircPrimer: a software for annotating circRNAs and determining the specificity of circRNA primers [PDF]
BMC Bioinformatics, 2018 Since circular RNAs (circRNAs) post-transcriptionally regulate gene expression, they have attracted increasing attention. However, there is no existing tool to annotate and extract spliced sequences for circRNAs and no tool to determine the specificity of circRNA primers.In this study, we present circPrimer, which allows users to search, annotate, and ...
Shanliang Zhong +4 more
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CircPrimer 2.0: a software for annotating circRNAs and predicting translation potential of circRNAs
BMC Bioinformatics, 2022 Abstract Background Some circular RNAs (circRNAs) can be translated into functional peptides by small open reading frames (ORFs) in a cap-independent manner. Internal ribosomal entry site (IRES) and N6-methyladenosine (m6A) were reported to drive translation of circRNAs.
Shanliang Zhong, Jifeng Feng
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Enhanced Intracellular Stability and Translation Efficiency of mRNA Drugs by a 2‐arm mRNA Platform
Advanced Science, EarlyView.We constructed a 2‐arm mRNA, characterized by a unique topology formed through the dimerization of two mRNA 3’ tails. The 2‐arm mRNA improves 3’ tail stability and resistance to nuclease degradation, resulting in an intracellular half‐life of up to 65 h. This method substantially enhances the translation capacity of mRNA drugs.
Xucong Teng +5 more
wiley +1 more source
The biogenesis, function and clinical significance of circular RNAs in breast cancer
Cancer Biology & Medicine, 2022 Circular RNAs (circRNAs) are noncoding RNAs that form covalently closed loop structures. CircRNAs are dysregulated in cancer and play key roles in tumorigenesis, diagnosis, and tumor therapy.
Yan Zeng +6 more
doaj +1 more source
Hyb:A bioinformatics pipeline for the analysis of CLASH (crosslinking, ligation and sequencing of hybrids) data [PDF]
, 2013 Peer reviewedPublisher ...
Aiba +32 more
core +2 more sources
Advanced Intelligent Discovery, EarlyView.Exosomes are emerging as powerful biomarkers for disease diagnosis and monitoring. This review highlights the integration of surface‐enhanced Raman spectroscopy with artificial intelligence to enhance molecular fingerprinting of exosomes. Machine learning and deep learning techniques improve spectral interpretation, enabling accurate classification of ...
Munevver Akdeniz +2 more
wiley +1 more source
Circular RNA circ-Olfm1 induces progression of Alzheimer’s disease by regulating FOXO3a
陆军军医大学学报Objective To investigate the role of circular RNAs （circRNA） in Alzheimer’s disease （AD） and its potential mechanism. Methods Six-month-old APP/PS1 mouse model of AD and wild type (WT) mice were subjected and then randomly divided into WT group, WT ...
YANG Hongyan, LIAO Qirong, HOU Mingliang
doaj +1 more source
Functions and clinical significance of circular RNAs in acute myeloid leukemia
Frontiers in Pharmacology, 2022 Circular RNAs (circRNAs) are a class of covalently closed single-stranded RNA molecules. Four types of circRNAs have been reported in animal cells, and they have typical characteristics in their biogenesis, nuclear export and degradation. Advances in our
Min Zhou +5 more
doaj +1 more source
Circulating cell-free nucleic acids: characteristics and applications [PDF]
, 2018 K
Biró, Orsolya +3 more
core +1 more source
CircRNAs and Fusion-circRNAs in cancer: New players in an old game
Cellular Signalling, 2020 Circular RNAs (circRNAs) are generated from 'back-splicing' events. Their circular structure makes them stable in cells and body fluids. These entities are involved in several human diseases including cancer, as they affect the expression of genes promoting proliferation, invasion, apoptosis, and angiogenesis.
Grazia Visci +5 more
openaire +3 more sources