Cell-type specific features of circular RNA expression. [PDF]
PLoS Genetics, 2013 Thousands of loci in the human and mouse genomes give rise to circular RNA transcripts; at many of these loci, the predominant RNA isoform is a circle. Using an improved computational approach for circular RNA identification, we found widespread circular
Julia Salzman +4 more
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CIRI: an efficient and unbiased algorithm for de novo circular RNA identification [PDF]
Genome Biology, 2015 Recent studies reveal that circular RNAs (circRNAs) are a novel class of abundant, stable and ubiquitous noncoding RNA molecules in animals. Comprehensive detection of circRNAs from high-throughput transcriptome data is an initial and crucial step to ...
Yuan Gao, Jinfeng Wang, Fangqing Zhao
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Circular RNA profiling reveals an abundant circHIPK3 that regulates cell growth by sponging multiple miRNAs [PDF]
Nature Communications, 2016 Circular RNAs (circRNAs) represent a class of widespread and diverse endogenous RNAs that may regulate gene expression in eukaryotes. However, the regulation and function of human circRNAs remain largely unknown.
Qiupeng Zheng +13 more
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Viroids are single-stranded covalently closed circular RNA molecules existing as highly base-paired rod-like structures. [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 1976 Viroids are uncoated infectious RNA molecules pathogenic to certain higher plants. Four different highly purified viroids were studied. By ultracentrifugation, thermal denaturation, electron microscopy, and end group analysis the following features were ...
Heinz L. Sänger +4 more
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Novel Role of FBXW7 Circular RNA in Repressing Glioma Tumorigenesis [PDF]
Journal of the National Cancer Institute, 2017 Background Circular RNAs (circRNAs) are RNA transcripts that are widespread in the eukaryotic genome. Recent evidence indicates that circRNAs play important roles in tissue development, gene regulation, and carcinogenesis.
Yibing Yang +12 more
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Scientific Reports, 2015 Circular RNAs are a recently (re-)discovered abundant RNA species with presumed function as miRNA sponges, thus part of the competing endogenous RNA network. We analysed the expression of circular and linear RNAs and proliferation in matched normal colon
Anna Bachmayr-Heyda +9 more
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Potential role of N6-methyladenosine modification in circular RNA biogenesis and function in the inflammatory responses [PDF]
Frontiers in Molecular MedicineN6-methyladenosine (m6A) is the best-studied post-transcriptional RNA modification. It refers to the methylation in the N6 position. M6A exists universally from viruses to mammalian cells and is highly abundant in RNA polymerase II-transcribed, protein ...
Heedoo Lee +3 more
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Foxo3 circular RNA promotes cardiac senescence by modulating multiple factors associated with stress and senescence responses [PDF]
European Heart Journal, 2016 William W. Du +7 more
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Detecting circular RNA from high-throughput sequence data with de Bruijn graph
BMC Genomics, 2020 Background Circular RNA is a type of non-coding RNA, which has a circular structure. Many circular RNAs are stable and contain exons, but are not translated into proteins.
Xin Li, Yufeng Wu
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Frontiers in Immunology, 2022 Circular DNAs derived from single-stranded RNA viruses play important roles in counteracting viral infection. However, whether double-stranded RNA viruses generate functional circular DNAs is still unknown. Using circDNA sequencing, divergent PCR, DNA in
Min Zhu +13 more
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