Results 31 to 40 of about 1,797,821 (330)
In vitro circularization of RNA [PDF]
RNA Biology, 2016 Over the past 2 decades, different types of circular RNAs have been discovered in all kingdoms of life, and apparently, those circular species are more abundant than previously thought. Apart from circRNAs in viroids and viruses, circular transcripts have been discovered in rodents more than 20 y ago and recently have been reported to be abundant in ...
Sabine Müller, Bettina Appel
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Research progress on circular RNA vaccines
Frontiers in Immunology, 2023 Owing to the success of linear mRNA coronavirus disease 2019 (COVID-19) vaccines, biopharmaceutical companies and research teams worldwide have attempted to develop more stable circular RNA (circRNA) vaccines and have achieved some preliminary results ...
Yu Bai +5 more
semanticscholar +1 more source
Circular RNAs and Cardiovascular Regeneration [PDF]
Frontiers in Cardiovascular Medicine, 2021 circular RNAs (circRNAs) are a type of non-coding RNAs that are widely present in eukaryotic cells. They have the characteristics of stable structure, high abundance, and cell or tissue specific expression. circRNAs are single-stranded RNAs that are covalently back spliced to form closed circular loops.
Wuqiang Zhu +3 more
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Functions of Circular RNA in Human Diseases and Illnesses
Non-Coding RNA, 2023 Circular RNAs (circRNAs) represent single-stranded RNA species that contain covalently closed 3′ and 5′ ends that provide them more stability than linear RNA, which has free ends.
Alison Gu +5 more
semanticscholar +1 more source
CircMarker: a fast and accurate algorithm for circular RNA detection
BMC Genomics, 2018 Background While RNA is often created from linear splicing during transcription, recent studies have found that non-canonical splicing sometimes occurs. Non-canonical splicing joins 3’ and 5’ and forms the so-called circular RNA.
Xin Li +4 more
doaj +1 more source
Circular RNA: metabolism, functions and interactions with proteins
Molecular Cancer, 2020 Circular RNAs (CircRNAs) are single-stranded, covalently closed RNA molecules that are ubiquitous across species ranging from viruses to mammals. Important advances have been made in the biogenesis, regulation, localization, degradation and modification ...
Weiyun Zhou +5 more
semanticscholar +1 more source
Circular RNA: A promising new star of vaccine
Journal of Translational Internal Medicine, 2023 Circular RNAs (circRNAs) are a class of single-stranded RNAs with covalently closed structures. Owing to their not having 3' or 5' ends, circRNAs are highly durable and insusceptible to exonuclease-mediated degradation.
Jindong Xie +10 more
semanticscholar +1 more source
Circular RNAs in and out of Cells: Therapeutic Usages of Circular RNAs
Molecules and Cells, 2023 RNAs are versatile molecules that are primarily involved in gene regulation and can thus be widely used to advance the fields of therapeutics and diagnostics. In particular, circular RNAs which are highly stable, have emerged as strong candidates for use on next-generation therapeutic platforms. Endogenous circular RNAs control gene regulatory networks
Mingyu Ju +3 more
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Technology in Cancer Research & Treatment, 2021 Objectives: Epidermal growth factor receptor-tyrosine kinase inhibitors are widely used for lung epidermal growth factor receptor-positive lung adenocarcinomas, but acquired resistance is inevitable.
Chenyue Dai MM +7 more
doaj +1 more source
Circular RNA-protein interactions: functions, mechanisms, and identification
Theranostics, 2020 Circular RNAs (circRNAs) are covalently closed, endogenous RNAs with no 5′ end caps or 3′ poly(A) tails. These RNAs are expressed in tissue-specific, cell-specific, and developmental stage-specific patterns.
Anqing Huang +4 more
semanticscholar +1 more source