Results 91 to 100 of about 5,707 (163)

DNA From Neutrophil Extracellular Traps Restricts Group 3 Innate Lymphoid Cells Function in Intestinal Epithelial Repair via CCDC25

The FASEB Journal, Volume 40, Issue 12, 30 June 2026.
DNA from neutrophil extracellular traps (NET‐DNA) restricts the function of IL‐22‐dependent ILC3s in intestinal defense through coiled‐coil domain containing protein 25 (CCDC25), which hinders the repair of intestinal epithelial cells and promotes the progression of UC.
Bo Xu, Xuezhou Ke, Xueqian Xie, Qi Yi, Chunjing Li, Meng Zhao, Xiangliang Deng, Qing Wang, Hongxu Chen, Rui Xu, Shuiling Cao, Ying Zhu, Lian Zhou, Qimei Wang, Xia Luo   +14 more
wiley   +1 more source

Higher citrullinated histone H3 is associated with postthrombotic syndrome: a cohort study

Journal of Thrombosis and Haemostasis
Postthrombotic syndrome (PTS) is a serious complication of deep vein thrombosis (DVT), linked to persistent inflammation and impaired thrombus resolution. Enhanced formation of neutrophil extracellular traps (NETs) is involved in DVT pathogenesis.We investigated whether increased NET formation, associated with an unfavorable fibrin clot phenotype ...
Julia Krupa-Zabiegała, Patryk Stanisław Michel, Konrad Stępień, Maciej Polak, Joanna Natorska, Anetta Undas   +5 more
openaire   +3 more sources

PADI4-mediated citrullination of histone H3 stimulates HIV-1 transcription

Nature Communications
Abstract HIV-1 infection establishes a reservoir of long-lived cells with integrated proviral DNA that can persist despite antiretroviral therapy (ART). Certain reservoir cells can be reactivated to reinitiate infection.
Luca Love, Bianca B. Jütte, Birgitta Lindqvist, Hannah Rohdjess, Oscar Kieri, Piotr Nowak, J. Peter Svensson   +6 more
openaire   +4 more sources

Citrullination of HP1γ chromodomain affects association with chromatin

Epigenetics & Chromatin, 2019
Background Stem cell differentiation involves major chromatin reorganisation, heterochromatin formation and genomic relocalisation of structural proteins, including heterochromatin protein 1 gamma (HP1γ). As the principal reader of the repressive histone
Meike Wiese, Andrew J. Bannister, Srinjan Basu, Wayne Boucher, Kai Wohlfahrt, Maria A. Christophorou, Michael L. Nielsen, David Klenerman, Ernest D. Laue, Tony Kouzarides   +9 more
doaj   +1 more source

Citrullinated Histone 3 as a Marker of NETosis at Opposite Ends of Hemostasis: Evidence From Thrombosis-Prone MPN and Bleeding-Prone Hemophilia

Clinical and Applied Thrombosis/Hemostasis
Background Neutrophil extracellular trap (NET) formation has emerged as a key driver of thrombosis in myeloproliferative neoplasms (MPNs). Its role in congenital bleeding disorders, however, remains unexplored.
Sercan Olcar MD, Tuğrul Elverdi MD, İbrahim Murat Bolayırlı MD, Ahmet Emre Eşkazan MD, Deniz Özmen MD, Melis Dila Özer Çerme MD, Ayşe Salihoğlu MD, Zafer Başlar MD, Muhlis Cem Ar MD   +8 more
doaj   +1 more source

Neutrophil α-defensin-1 is present in human stroke thrombi and induces NETosis in vitro

Frontiers in Immunology
BackgroundIschemic stroke thrombi contain complex immunothrombotic components, including neutrophil extracellular traps (NETs), which contribute to thrombus stability and resistance to fibrinolysis.
Edward Theodore Littleton, Edward Theodore Littleton, Samuel George Thomas, Eleanor Woodhead, Julie Rayes, Alexander Brill   +5 more
doaj   +1 more source

Presence of Neutrophil Extracellular Traps and Citrullinated Histone H3 in the Bloodstream of Critically Ill Patients

PLoS ONE, 2014
Neutrophil extracellular traps (NETs), a newly identified immune mechanism, are induced by inflammatory stimuli. Modification by citrullination of histone H3 is thought to be involved in the in vitro formation of NETs. The purposes of this study were to evaluate whether NETs and citrullinated histone H3 (Cit-H3) are present in the bloodstream of ...
Tomoya Hirose, Shigeto Hamaguchi, Naoya Matsumoto, Taro Irisawa, Masafumi Seki, Osamu Tasaki, Hideo Hosotsubo, Norihisa Yamamoto, Kouji Yamamoto, Yukihiro Akeda, Kazunori Oishi, Kazunori Tomono, Takeshi Shimazu   +12 more
openaire   +4 more sources

Kringle-Dependent Inhibition of Plasmin-Mediated Fibrinolysis by Native and Citrullinated Core Histones

International Journal of Molecular Sciences
The fibrin matrix of thrombi is intertwined with neutrophil extracellular traps (NETs) containing histones that render resistance to fibrinolysis. During NET formation, histones are citrullinated. Our study addresses the question of whether citrullination modifies the fibrin-stabilizing effects of histones.
Erzsébet Komorowicz, Anna Gurabi, András Wacha, László Szabó, Olivér Ozohanics, Krasimir Kolev   +5 more
openaire   +2 more sources

Case report: In vivo detection of neutrophil extracellular traps in a dog with thrombosis induced by bacterial vasculitis

Frontiers in Veterinary Science
This case report describes NETosis as a cause of thrombosis in an 18.3 kg, 8-year-old intact male mixed-breed dog with bacterial vasculitis. The dog presented with sudden paresis of the thoracic limb, characterized by cyanosis, absent arterial pulse, and
Ju-Yun Kim, Hyun-Jung Han
doaj   +1 more source

Correction: Circulating cell free DNA and citrullinated histone H3 as useful biomarkers of NETosis in endometrial cancer. [PDF]

J Exp Clin Cancer Res, 2023
Ronchetti L, Terrenato I, Ferretti M, Corrado G, Goeman F, Donzelli S, Mandoj C, Merola R, Zampa A, Carosi M, Blandino G, Conti L, Lobascio AM, Iacobelli M, Vizza E, Piaggio G, Gurtner A.   +16 more
europepmc   +1 more source